DRSC/TRiP Functional Genomics Resources

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Protein Alignment SP2353 and Lamb1

DIOPT Version :10

Sequence 1:NP_611082.2 Gene:SP2353 / 36771 FlyBaseID:FBgn0034070 Length:1361 Species:Drosophila melanogaster
Sequence 2:XP_003750185.1 Gene:Lamb1 / 298941 RGDID:1306311 Length:1834 Species:Rattus norvegicus


Alignment Length:1397 Identity:254/1397 - (18%)
Similarity:404/1397 - (28%) Gaps:518/1397 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 SSASIAVGAIP--EPEEAAFQGHC-------GHTSPCEQLCYEIH-------DGMYECDCIEGYE 74
            |.|...:|.||  .|.::. .|:|       |..  |:| |...|       ||...|||..|..
  Rat   505 SCACNPLGTIPGGNPCDSE-TGYCYCKRLVTGQR--CDQ-CLPQHWGLSNDLDGCRPCDCDLGGA 565

  Fly    75 LNKNGYSCQVINATSNSLDGRGKSDEDVLYQKGASFSAKLANDDGGKSMAKSTFALSAAQSASP- 138
            ||.   ||                                 ::|.|:.            |..| 
  Rat   566 LNN---SC---------------------------------SEDSGQC------------SCLPH 582

  Fly   139 -AGNENGEDESG---SEGDSYDYGELEDSNSETQEQKQKSLNLQQQQQQQQKVNS---------- 189
             .|.:..|.|||   :..|.|.| |.|::|      ....:.:.:::..|.::.|          
  Rat   583 MIGRQCNEVESGYYFTTLDHYIY-EAEEAN------LGPGVVVVERRYIQDRIPSWTGPGFVRVP 640

  Fly   190 ----NDYYISAESINFNSESE--GQEQQDVADF--KAASTMLPSSVPPTPSRSTTRATASTTTTT 246
                .:::|  ::|..:.|.|  .:.:..:.|.  ||..|:......||.||.............
  Rat   641 EGAYLEFFI--DNIPHSMEYEILIRYEPQLPDHWEKAVITVQRPGRIPTSSRCGNTVPDDDNQVV 703

  Fly   247 TTTRRS-------PTRAPK-----QRVDVDYGEGDGSDDYS------------YSYKSDMSVYDD 287
            :.:..|       |....|     .|:::......|||..|            |....|:.....
  Rat   704 SLSPGSRYVVLPRPVCFEKGMNYTVRLELPQYTASGSDVESPYTLIDSLVLMPYCKSLDIFTVGG 768

  Fly   288 VNNNQLNLRRNSKSQTYQQTSNTNTAKNRRKYP--NVTSNKV--------QMHITRETNRLENIS 342
            ..:.::.   ||..:|:|:......:::..|.|  :|..|.:        |..:..|.:...::|
  Rat   769 SGDGEVT---NSAWETFQRYRCLENSRSVVKTPMTDVCRNIIFSISALIHQAGLACECDPQGSLS 830

  Fly   343 A----------AEPAVVGAAMTTDRSTP--------TCN-LDCGSDGICALEATAASSRCLCPFG 388
            :          ..|.|||  .|.:|..|        .|. .||...|..:....|.:.:|.|..|
  Rat   831 SVCDPNGGQCQCRPNVVG--RTCNRCAPGTFGFGPNGCKPCDCHLQGSVSAFCDAVTGQCHCFQG 893

  Fly   389 KTGNGCQEDIRAHVPRFAKRSWLAFPALHGAYKHVQLRIEFRPESFDGIILLSGERDDLTGDFMA 453
            .....|...:    |.|    | .||:.             :|...:|   .:.:.|.:||:.::
  Rat   894 IYARQCDRCL----PGF----W-GFPSC-------------QPCQCNG---HAEDCDTVTGECLS 933

  Fly   454 LLLNKGFVEFWFDCGSGVGSVRSRETILLNEWNSVIIYRHRWDAWLVLNHGTKVQGR-------- 510
            ..          |..:|                      |..:..|...:|..:.|.        
  Rat   934 CQ----------DYTTG----------------------HNCERCLAGYYGDPIIGSGDHCRPCP 966

  Fly   511 ------SNGLFSRITFREPVFL--------GGIGNITGLAKRLPLAEGFAGCIRRFVANEHDYKF 561
                  |...|:|..:::||.|        |.||:...            ||...:..|..|:..
  Rat   967 CPDGPDSGRQFARSCYQDPVTLQLACVCDPGYIGSRCD------------GCASGYFGNPSDFGG 1019

  Fly   562 TEHP--LGDVINGFDIQDC--STDKCVRYPCQHGGKCLPSDQGAIC-LCPIGFVGDLCEIRMDLQ 621
            :..|  ....|:..|.:.|  .|.:|:        |||...:|..| .|..|:.||  .:|.|.:
  Rat  1020 SCQPCQCHHNIDTTDPEACDKETGRCL--------KCLYHTEGDHCQFCQHGYYGD--ALRQDCR 1074

  Fly   622 VPAFNGSSFLRYAPLGDSALIWLELKVTLKPEQADGLILYSG---------PEHRGDFIALYLND 677
            ....|....:|                    |..:|...:..         |...|...     |
  Rat  1075 KCVCNYLGTVR--------------------EHCNGSDCHCDKTTGQCSCLPNVIGQNC-----D 1114

  Fly   678 GFVEFAFDLGSG----PALVRSEHSLSLGQWHTIKISRTARLAVLKVDKHQEVLTISSNGFWHLS 738
            ......:.|.||    |....:.||                                        
  Rat  1115 RCAPHTWQLASGTGCEPCNCNAVHS---------------------------------------- 1139

  Fly   739 LDQNLFVGGVNHVDRLPLDLKYKPFFVGCIQRIDINGHSLGIVAEALGGSNIGNCPH-------- 795
                 |....|.             |.|..|           .....||.....|..        
  Rat  1140 -----FGPSCNE-------------FTGQCQ-----------CMPGFGGRTCSECQELFWGDPDV 1175

  Fly   796 ACVARPCGPLAECVPQME--SYECRC--SIHNERCNKAAE----VPPEQLP-------------E 839
            .|.|..|.|.....||.:  :.:|.|  .:...||:|...    |.|:..|             |
  Rat  1176 ECRACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCDKCTRGYSGVFPDCTPCHQCFALWDVIIGE 1240

  Fly   840 LA------LHKSKVL----------ETKDNGEAAKKVSG----LAHKKHSKKHRNL----HKPTP 880
            |.      |.|:|.|          ||.|:.|  |||:.    ||....::..:|:    .:...
  Rat  1241 LTNRTHKFLEKAKALKISGVIGPYRETVDSVE--KKVNEIRDILAQSPAAEPLKNIGILFEEAEK 1303

  Fly   881 ATSTTTSTTSTTTTTTEAPSERTEEATAGALSNEEIEDDIIFRLVQQQQQQKELKKQHQQTTTTA 945
            .|...|...:.........:.|: .:|||.|...:.|...:.:.|.:..:|.|..|   .:....
  Rat  1304 LTKDVTEKMAQVEVKLSDTASRS-NSTAGELDALQAEAGSLDKTVNELAEQLEFIK---NSDIQG 1364

  Fly   946 PATSTTSSGPSKAKPRLSGKHHASKHEHHLKPNAAFTRKLSRLPTHYESFQTNPDSDILTFEDNN 1010
            ...|.|             |:.....|...:.||:.|...|   |..:|..|....:.|..|..:
  Rat  1365 ALDSIT-------------KYFQISLEAEKRVNASTTDPNS---TVEQSALTRDRVEDLMLERES 1413

  Fly  1011 DWVTSLQQQ-EYGDAMAASQVPL---AFEDASPGTPRSSDNNEDD-------------------- 1051
            .:....::| ...|.:|.....|   |..:.:.||...:|.:|.:                    
  Rat  1414 QFKEKQEEQARLLDELAGKLQSLDLSAAAEMTCGTHPGADCSESECGGPNCRTDEGEKKCGGPGC 1478

  Fly  1052 -----------ENAFVFDESLFDASDGTEEYQR------------KQLAQDMKRIMSNSNAHSSH 1093
                       :.|..||..:.:|....|:..:            ||.|||   ::..:||    
  Rat  1479 GGLVTVAHSAWQKAMDFDRDVLNALAEVEQLSKMVSEAKVRADEAKQNAQD---VLLKTNA---- 1536

  Fly  1094 KKAEVQFPPQGSQEVGTANED----TSQYSDDYNDDEL-LTPVMQGGEEVKLEQHTSSTPQTHTD 1153
                      ..::|..:|||    ..|..|...:|.. |..:.....|| |:....||||... 
  Rat  1537 ----------TREKVDRSNEDLRNLIKQIRDFLTEDSADLDSIEAVANEV-LKMEMPSTPQQLQ- 1589

  Fly  1154 WSLLKKFDLSAEHQSQVQGVRKNFGACFAGSD 1185
             :|.:......|..|||:.:.:...|..|.::
  Rat  1590 -NLTEDIRERVETLSQVEVILQQSAADIARAE 1620

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SP2353NP_611082.2 FXa_inhibition 53..82 CDD:464251 12/35 (34%)
LamG 404..555 CDD:238058 26/172 (15%)
EGF 583..612 CDD:394967 8/29 (28%)
LamG 625..774 CDD:238058 18/161 (11%)
LamG 1205..1340 CDD:214598
Lamb1XP_003750185.1 Laminin_N 83..317 CDD:459653
EGF_Lam 319..371 CDD:238012
EGF_Lam 383..435 CDD:238012
Laminin_EGF 446..503 CDD:395007
EGF_Lam 505..556 CDD:238012 15/54 (28%)
EGF_Lam 557..>596 CDD:238012 17/86 (20%)
EGF_Lam 821..866 CDD:214543 9/46 (20%)
Laminin_EGF 869..917 CDD:395007 14/69 (20%)
EGF_Lam 914..959 CDD:238012 11/79 (14%)
Laminin_EGF 965..1021 CDD:395007 13/67 (19%)
Laminin_EGF 1024..1068 CDD:395007 14/53 (26%)
Laminin_EGF 1076..1129 CDD:395007 10/77 (13%)
Laminin_EGF 1132..1180 CDD:395007 11/116 (9%)
Laminin_EGF 1180..>1219 CDD:395007 9/38 (24%)
YhaN 1250..>1723 CDD:443752 81/413 (20%)
SMC_prok_B 1504..>1824 CDD:274008 30/137 (22%)
cc_LAMB1_C 1762..1834 CDD:411971
Blue background indicates that the domain is not in the aligned region.

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