Protein Alignment SP2353 and lamb4

DIOPT Version :10

• Sequence 1: NP_611082.2
• Gene: SP2353 / 36771
• FlyBaseID: FBgn0034070
• Length: 1361
• Species: Drosophila melanogaster
• Sequence 2: NP_775383.2
• Gene: lamb4 / 286831
• ZFINID: ZDB-GENE-021226-2
• Length: 1827
• Species: Danio rerio
• Alignment Length: 751
• Identity: 131/751 - (17%)
• Similarity: 213/751 - (28%)
• Gaps: 303/751 - (40%)

  Fly    11 CRVVCVWLLLVLSSLSSASIAVGAIPEPEEAAFQGHCGHTSPCEQLCYEIHDGMYECD-CIEGY- 73
            ||  |.:|         .:|.||...:|.    .|.|    .||...|.     .:|| |:.||
Zfish   449 CR--CNFL---------GTIQVGNPCDPT----TGRC----ICEHFAYG-----SQCDQCLPGYW 489

  Fly    74 ELNKNGYSC--------QVINATSNSLDGRGKSDEDVLYQKGASFSAKLANDDG-GKSMAKSTFA 129
            .|....|.|        ..:....:|:||:.|...:::.||        .||.. |..:|...|.
Zfish   490 GLGNTVYGCIPCDCDIGGALKTECSSVDGQCKCRPNMVGQK--------CNDPAPGYFLAPLDFY 546

  Fly   130 LSAAQSASPAGNENGEDESGSEGDSYDYGELEDSNSETQEQKQKSLNLQQQQQQQQKVNSNDYYI 194
            :..|::|:|..                                                     :
Zfish   547 IYEAENAAPLA-----------------------------------------------------V 558

  Fly   195 SAESIN---FNSESEGQEQQDVADFKAASTMLPSSVPPTPSRSTTRATASTTTTTTTTRRSPTRA 256
            .:..|.   |...:||..::        .|.|| ..||.|..|:.......|.       .|:.|
Zfish   559 ISPFIGPPPFVYPTEGIPER--------PTKLP-LCPPAPKPSSVPYREHITV-------QPSPA 607

  Fly   257 P--------------KQRVDVDYGEGDGSDDYSYSYKSDMSVYDDVNNNQLNLRRNSKSQTYQQT 307
            |              :||              .|.:|        ::|.:|.:.:..|.||.::
Zfish   608 PHNPQVTLPMCEHYFRQR--------------GYDFK--------ISNGRLVVVKREKRQTRRR- 649

  Fly   308 SNTNTAKNRRKYPNVTSNKVQMHITRETN------------RLENISAAEPAVVGAAMTTD---- 356
                 .:.:|..|....:.:|:.:.:..|            |:::.:.....|.....|.|
Zfish   650 -----RQGQRTIPFEPGSPLQILLRQRANDQSITWTGLGFVRVQDGAGLRFTVSNIPATLDYYVV 709

  Fly   357 -RSTPTCNLD----------------CGSDGICALEATAASSR--------CLCPFGKTGNGCQE 396
             |..|....|                |.:|....:....||.|        ||    ..||....
Zfish   710 VRYEPESTDDWTAIVSILSFGSEDERCPNDQSNKMFTLPASGRTATLDLPVCL----SDGNQYHV 770

  Fly   397 DIR--------------------------AHVPRFAKRSWLAFPALHGAYKHVQLRIEFRPESFD 435
            ||.                          ..||.|..:|:|   :....|:.::|.::...::..
Zfish   771 DITFRKQPSEDPHSSSFILIDSLGLIPKVESVPNFCSQSYL---SQFQQYRCIELAVQAGGQTLP 832

  Fly   436 GII-LLSGERDDLTGDFMALLLNKGFVE--------FWFDCGSGVGSVRSRETILLNEWNSVIIY 491
            .:. :|.|.        |:..::.|.|.        :...|....|..:.:..::
Zfish   833 EVCEMLIGS--------MSAFIHNGAVSCNCHHVGAYGSSCSKFGGQCQCKPNVI---------- 879

  Fly   492 RHRWDAWLVLNHGTKVQGRS------NGLFSRITFREPVFLGGIGNITGLA--KRLPLAEGFAGC 548
            ....|:...|.:|....|.|      :|..:.:..:..........||||.  :..|...||..|
Zfish   880 GRCCDSCAPLTYGLGPNGCSPCDCDRSGSTTELCDQTTGQCSCRDGITGLQCNRCYPGYYGFPLC 944

  Fly   549 IRRFVAN-----------------EHD-----YKFTEHPLGDVINGFDIQDC------STDKCVR 585
             ||...|                 ||.     .:..|..:||.::|...:.|      .:.:...
Zfish   945 -RRCQCNRLADICDPITGDCLDCREHSAGRNCERCEEGYVGDPVSGQPCEPCLCPDLNGSGRFFA 1008

  Fly   586 YPCQHGGK-------CLPSDQGAIC-LCPIGFVGDL 613
            :.|....:       |||...|..| .|..||.|||
Zfish  1009 FSCNKDPRSGAPYCECLPGHTGPQCDSCSPGFYGDL 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP2353	NP_611082.2	FXa_inhibition	53..82	CDD:464251	10/30 (33%)
		LamG	404..555	CDD:238058	28/167 (17%)
		EGF	583..612	CDD:394967	9/36 (25%)
		LamG	625..774	CDD:238058
		LamG	1205..1340	CDD:214598
lamb4	NP_775383.2	Laminin_N	30..265	CDD:459653
		EGF_Lam	266..324	CDD:238012
		EGF_Lam	333..386	CDD:238012
		Laminin_EGF	397..446	CDD:395007
		EGF_Lam	449..498	CDD:238012	20/72 (28%)
		EGF_Lam	500..>539	CDD:238012	9/46 (20%)
		EGF_Lam	853..898	CDD:214543	5/54 (9%)
		Laminin_EGF	901..949	CDD:395007	11/48 (23%)
		EGF_Lam	946..993	CDD:238012	8/46 (17%)
		EGF_Lam	994..1049	CDD:238012	13/51 (25%)
		Laminin_EGF	1054..1098	CDD:395007
		Laminin_EGF	1106..1165	CDD:395007
		EGF_Lam	1162..1205	CDD:238012
		EGF_Lam	1211..1259	CDD:238012
		Domain II	1258..1449
		PRK03918	<1292..1822	CDD:235175
		Domain alpha	1450..1476
		Domain I	1477..1827
		cc_LAMB4_C	1756..1825	CDD:411972