Protein Alignment SP2353 and lamb1a

DIOPT Version :10

• Sequence 1: NP_611082.2
• Gene: SP2353 / 36771
• FlyBaseID: FBgn0034070
• Length: 1361
• Species: Drosophila melanogaster
• Sequence 2: NP_775382.1
• Gene: lamb1a / 286830
• ZFINID: ZDB-GENE-021226-1
• Length: 1785
• Species: Danio rerio
• Alignment Length: 1662
• Identity: 283/1662 - (17%)
• Similarity: 472/1662 - (28%)
• Gaps: 630/1662 - (37%)

  Fly     6 HHHHHCRV-VCVWLLLVLSSLSSASIAVGAIPEPEEAAFQGHCGHTSP---------------CE 54
            ||.|.|.. :.|:       .:|.:::.|...:.:......:|....|               ||
Zfish   336 HHSHSCHFDMAVY-------RASGNVSGGVCDDCQHNTMGHNCEQCKPFFHQHPEKDIRDPNICE 393

  Fly    55 Q------------LCYEIHD---GMY--ECDC---IEG----------YELNKNGYSCQVINATS 89
            .            :|..:.|   |:.  :|.|   :||          |.|:::...||  ..|.
Zfish   394 PCNCDPVGSLNGGVCDPMTDVSLGLISGQCRCKPNVEGERCDQCKQGHYGLSEDPLGCQ--PCTC 456

  Fly    90 NSL---DGRGKSDEDVLYQKGASFSAKLANDDGGKSMAKSTFALSAAQSASPAGNENGEDESGSE 151
            |:|   .|....|.|    .|..:..:|.............:.||             .|..|..
Zfish   457 NALGTVPGGSPCDTD----SGNCYCKRLVTGRNCDQCLPQHWGLS-------------NDMDGCR 504

  Fly   152 GDSYDYGELEDSN-SETQEQKQKSLNLQQQQQQQQKVNSNDYYISAESINFNSESEGQEQQDVAD 215
            ....|:|...::| |....|.|...::..::..|  |.|..|:|:.:...:.:|.        |.
Zfish   505 PCDCDHGGAINNNCSPVSGQCQCREHMFGRRCDQ--VESGFYFIALDHYTYEAEE--------AK 559

  Fly   216 FKAASTMLPSSVPPTPSRSTT-------------------------------------------R 237
            |....|::|.:.|...|.:.|                                           .
Zfish   560 FGPGVTVVPRNHPQDRSPTWTGIGFVNVPEGAFLEFSIDNIPYSMEYDLIIRYEPQLPEQWEEVL 624

  Fly   238 ATASTTTTTTTTRRSPTRAP---KQRVDVDYG-------------EGDGSDDYSYSYKSDMSVYD 286
            .|.......|...|.....|   .|.|.:..|             ||     .:|:.:..:|:|.
Zfish   625 MTVIRPRVITADSRCANTMPDDDNQMVSLHPGSRYVVLPRPVCFEEG-----LNYTVRLSLSLYS 684

  Fly   287 DVNNNQ---------------LNLRRNSKSQTYQQTSNTNTA-KNRRKYPNVTSNKVQMHITRET 335
            .:::.|               .||...|.|.|......||:| :|.::|
Zfish   685 ALSDVQSPYTLIDSIVLMPHCKNLDIFSGSGTEGGNLVTNSAWENFQRY---------------- 733

  Fly   336 NRLENISAAEPAVVGAAMT-------------TDRSTPTCNLDCGSDGICALEATAASSRCLCPF 387
            ..|||    ..|||...||             ..:....|  .|...|..:.....:..:|.|..
Zfish   734 RCLEN----SQAVVKTPMTDICRNYIFSVSALLHQGVKAC--QCDPQGSLSTVCDPSGGQCQCRP 792

  Fly   388 GKTGNGCQEDIRAHVPRFAKRSWLAFPALHGAYKHVQLRIEFRPESFDGIILLSGERDDLTGDFM 452
            ...|..|.        |.|..::|..|  .|.          ||
Zfish   793 NVVGRNCD--------RCAPATFLFXP--QGC----------RP--------------------- 816

  Fly   453 ALLLNKGFVEFWFDCGSGVGSVRSRETILLNEWNSVIIYRHRWDAWLVLNHGTKVQGRSN---GL 514
                        .|| |..|||.|              |.|            :..|:..   |.
Zfish   817 ------------CDC-SPEGSVHS--------------YCH------------EATGQCECIAGA 842

  Fly   515 FSRITFREPVFLGGIGNITGLAKRLPLAEGFAGCIRRFVANEHDYKF---TEHPLG--DVINGFD 574
            :.|...|                .||...||..| |....|.|..:.   |...|.  |...|.:
Zfish   843 YGRQCDR----------------CLPGYWGFPNC-RPCTCNGHAEQCDPQTGQCLSCRDHTTGHN 890

  Fly   575 IQDC-----------STDKCVRYPC----------QHGGKCL--PSDQGAICLCPIGFVGDLCEI 616
            .:.|           |.|.|  .||          |..|.|.  |......|:|..|:.|..||
Zfish   891 CERCLGGYYGDPVLGSGDHC--RPCMCPDGPGSGRQFSGACYKSPDSSQVFCVCNQGYKGARCE- 952

  Fly   617 RMDLQVPAFNGSSFLRYAPLGDSALIWLELKVTLKPEQADGLILYSGPE----HRGDFI-ALYLN 676
               ...|.:.|:..              |:....:|.|.:..|....||    ..|..: .||..
Zfish   953 ---ECAPGYYGNPH--------------EVGGECRPCQCNSNIDMMDPESCDARTGACVKCLYHT 1000

  Fly   677 DGFVEFAFDLG-SGPALVRSEHSLSLGQWHTIKISRTARLAVLKVDKHQEVLTISSNGFWHLSLD 740
            :|.......|| .|.||.:|.......|..|:                :|:.....|....|:..
Zfish  1001 EGESCNRCRLGYYGNALTQSCRKCVCNQMGTV----------------EEMCPSPGNCNCDLTSG 1049

  Fly   741 QNLFVGGV--NHVDRLPLDLKYKPFFVGCIQRIDIN-GHSLGIVAEALGGSNIGNCPHAC----- 797
            |.|.:..|  .|.|:...|........|| :..|.: .||.|.....:    :|.|  :|
Zfish  1050 QCLCLPNVVGQHCDQCAPDTWNMASGKGC-EDCDCDPNHSFGSSCNEI----MGQC--SCKPGFG 1107

  Fly   798 --VARPCGPLAECVPQMESYECRC---SIHNERCNK-----------------------AAEVP- 833
              ..|.|..|....|:::.:.|.|   .|..::|||                       ..|.|
Zfish  1108 GRTCRECRELFWGNPEVKCHACDCDPRGIAEQQCNKVTGHCVCVEGVSGPRCDTCARGYTGEFPQ 1172

  Fly   834 ------------------PEQLPELALHKSKVLETKDNGEAAKKVSGLAHKKHSKKHRNLHKPTP 880
                              ..|...|....:.:..|...|.....::.:.:..:|  .||:....|
Zfish  1173 CERCHQCFAEWDIIVGDLTNQTHRLVQKVNTIKATGITGPYQATINNVENSANS--IRNILAQNP 1235

  Fly   881 ATSTTTSTTSTTTTTTEAPSER------TEEATAGALSNEEIEDDIIFRLVQQQQQQ-----KEL 934
            ||...|.........|...:|.      ||| |...:|::....|...:.::::.|:     |:|
Zfish  1236 ATQPLTEIQGLLEQATALMAEMNSNLNLTEE-TLSEISSDNNSTDTKLKSLKEEAQKLEQTVKDL 1299

  Fly   935 KKQHQQTTTT----APATSTTSSGPSKAKPRLSGKHHASKHEHHLKPNAAFT------RKLSRLP 989
            ::|.:....:    |.|:.|              :::.......::.||:.|      .:.:.|.
Zfish  1300 REQVEFVKNSDIRGARASVT--------------RYYEQSQNAEIRANASTTDPYNLVNQSATLR 1350

  Fly   990 THYESFQTNPDSDILTFEDNNDWVTSLQQQEYG---DAMAASQVPLAFEDASP---GTPRSSDNN 1048
            |..|.....      |.|:.|.     :|.|:.   |.:|.....|...:.|.   |:|..|:|.
Zfish  1351 TETEELMNQ------TKEEFNQ-----RQDEFSKKLDNLAGQLETLDLSELSEKTCGSPAGSENC 1404

  Fly  1049 EDD--------------------------------ENAFVFDESLFDASDGTEEYQRKQLAQDMK 1081
            .|.                                :.|..||..:..|.:..::         :.
Zfish  1405 ADSRCGGLSCVDMQGSRKCGGEGCDGLTTLAHNAWQKAKDFDLEIISAMEEVDK---------LS 1460

  Fly  1082 RIMSNSNAHSSHKKAEVQFPPQGSQEVGTANEDTSQYSDDYNDD--ELLTPV----MQGGEEVK- 1139
            :::|.:...:...|.       .:|||.....:|.:..|..|::  :|:..:    .|.|.:::
Zfish  1461 KMVSEAKVKADEAKL-------NAQEVLAKTNETKKRVDSSNEELRQLIKQIRDFLTQDGADLES 1518

  Fly  1140 --------LEQHTSSTPQTHTDWSLLKKFDLSAEHQSQVQGVRKNFGACFAGSDSYFHYNDADTM 1196
                    |:....:||               |:.|:..:.:|:..|:             ...:
Zfish  1519 IEAVANEVLQMQMPTTP---------------AQLQNLTEEIRERVGS-------------LTDV 1555

  Fly  1197 SQVISYSIDLNLRIKTHSENGVILWTGRQGTTEEHDDYLSLGIEQGYLHFRYDLGSGEVDIRFNG 1261
            ..:::.|....||.::      :|...|:...|..                        |::...
Zfish  1556 EDILNQSAADILRAES------LLEQARKARKEAS------------------------DVKSTA 1590

  Fly  1262 TKVSDGLWHRVRAIRNS-----QEGYLEVDGRKTVTLRAPGKLRQLNTDTGLYVGGMPDVGYFTH 1321
            ..|.:.|.|..|| :||     ::..:::.|.:.:.:....:    .:|:.|.:...      |.
Zfish  1591 EMVKEALQHAERA-QNSVAEALKQAAVDIKGTQDLLVSVESE----TSDSELKLSNA------TR 1644

  Fly  1322 QRYFSGIVGCISEIVLAGEMKLNFDPNTLGTEHNVET 1358
            :     ::...|::.|..|..||...:...||...|:
Zfish  1645 R-----LLKLESDVALLKEKALNTSISANSTEKEAES 1676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP2353	NP_611082.2	FXa_inhibition	53..82	CDD:464251	11/58 (19%)
		LamG	404..555	CDD:238058	26/153 (17%)
		EGF	583..612	CDD:394967	10/40 (25%)
		LamG	625..774	CDD:238058	31/156 (20%)
		LamG	1205..1340	CDD:214598	19/139 (14%)
lamb1a	NP_775382.1	Laminin_N	31..266	CDD:459653
		EGF_Lam	268..320	CDD:238012
		Laminin_EGF	<353..382	CDD:395007	3/28 (11%)
		EGF_Lam	394..452	CDD:238012	9/57 (16%)
		EGF_Lam	453..504	CDD:238012	12/67 (18%)
		EGF_Lam	505..548	CDD:238012	11/44 (25%)
		EGF_Lam	769..814	CDD:214543	11/56 (20%)
		Laminin_EGF	817..865	CDD:395007	19/91 (21%)
		EGF_Lam	862..907	CDD:238012	7/44 (16%)
		Laminin_EGF	<934..969	CDD:395007	9/52 (17%)
		Laminin_EGF	972..1018	CDD:395007	12/45 (27%)
		Laminin_EGF	1024..1078	CDD:395007	11/69 (16%)
		Laminin_EGF	1081..1129	CDD:395007	11/53 (21%)
		Laminin_EGF	1129..>1168	CDD:395007	6/38 (16%)
		Myosin_tail_1	1247..>1756	CDD:460256	83/546 (15%)
		cc_LAMB1_C	1712..1784	CDD:411971