DRSC/TRiP Functional Genomics Resources

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Protein Alignment SP2353 and LAMA1

DIOPT Version :10

Sequence 1:NP_611082.2 Gene:SP2353 / 36771 FlyBaseID:FBgn0034070 Length:1361 Species:Drosophila melanogaster
Sequence 2:NP_005550.2 Gene:LAMA1 / 284217 HGNCID:6481 Length:3075 Species:Homo sapiens


Alignment Length:1437 Identity:264/1437 - (18%)
Similarity:470/1437 - (32%) Gaps:506/1437 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KHHHHHCRVVCVW----------LLLVLSSLSSASIAVGAIPEPEEAAFQGHCGHTSPCEQLCYE 59
            :|...|...:.:|          |::.:|..::..:...|  |...|.||              .
Human  1832 EHLEDHQDKLLLWSAKIRHHIDDLVMHMSQRNAVDLVYRA--EDHAAEFQ--------------R 1880

  Fly    60 IHDGMYECDCIEGYELNKNGYSCQVINATSNSLDGRGKSDEDVLY--QKGASFSAKLANDDGGKS 122
            :.|.:|     .|.|..:|    ..:||||.:.         |.|  |.....|.:||.|     
Human  1881 LADVLY-----SGLENIRN----VSLNATSAAY---------VHYNIQSLIEESEELARD----- 1922

  Fly   123 MAKSTFALSAAQSASPAGNENGEDESGSEGDSYDYGELEDSNSETQEQKQKSLNLQQQQQQQQKV 187
             |..|...::..|.|...|.....:..|.       .|::.|:.:::....:|.|.:.:.:..:.
Human  1923 -AHRTVTETSLLSESLVSNGKAAVQRSSR-------FLKEGNNLSRKLPGIALELSELRNKTNRF 1979

  Fly   188 NSNDYYISAESINFNSESEGQEQQDVADFKAASTMLPSSVPPTPSRSTTRATASTTTTTTTTRRS 252
            ..|...|:.           |..:.:...:|    :|..:....:::...||:::.:..:|.|  
Human  1980 QENAVEITR-----------QTNESLLILRA----IPKGIRDKGAKTKELATSASQSAVSTLR-- 2027

  Fly   253 PTRAPKQRVDVDYGEGDGSDDYSYSYKSDMSVYDDVNNNQLNLRR--NSKSQTYQ--QTSNTNTA 313
                     ||                  ..:..::.|...:|.|  .:..:|:|  |.|...|.
Human  2028 ---------DV------------------AGLSQELLNTSASLSRVNTTLRETHQLLQDSTMATL 2065

  Fly   314 KNRRKYPNVTSNKVQMHI---------TRETNRLENIS---------AAEPAVVGAAMTTDRSTP 360
            ...||..:|   ::|.::         ..|.|...|:|         ..:.|.:..|::.||   
Human  2066 LAGRKVKDV---EIQANLLFDRLKPLKMLEENLSRNLSEIKLLISQARKQAASIKVAVSADR--- 2124

  Fly   361 TCNLDCGSDGICALEATAASSRCLCPFGKTGNGCQEDIRAHVPRFAKRSWLAFPALHGAYKHVQL 425
                ||                               |||:.|:.:..::..            |
Human  2125 ----DC-------------------------------IRAYQPQISSTNYNT------------L 2142

  Fly   426 RIEFRPESFDGIILLSGERDDLTGDFMALLLNKGFVEFWFDCGSGVGSVRSRE-TILLNEWNSVI 489
            .:..:.:..|.::...|  .....||:|:.:.:|.|.|.:|.|||...:...: .|..|.|:|:.
Human  2143 TLNVKTQEPDNLLFYLG--SSTASDFLAVEMRRGRVAFLWDLGSGSTRLEFPDFPIDDNRWHSIH 2205

  Fly   490 IYRHRWDAWLVLNHG-----------------TKVQGRSNGLFSRITFREPVFLGGIGNITGLAK 537
            :.|..       |.|                 :|..|.:|.|  .:.....:|:||:|   |..|
Human  2206 VARFG-------NIGSLSVKEMSSNQKSPTKTSKSPGTANVL--DVNNSTLMFVGGLG---GQIK 2258

  Fly   538 RLPLAE--GFAGCIRRFVANEHDYKFTEHPLGDV-INGFDIQDCSTDKCVRYPCQHGGKCLPSDQ 599
            :.|..:  .|.||                 ||:. :||..|      ....| .:..|||    :
Human  2259 KSPAVKVTHFKGC-----------------LGEAFLNGKSI------GLWNY-IEREGKC----R 2295

  Fly   600 GAICLCPIGFVGDLCEIRMDLQVPA--FNGSSFL---RYAPLGDSALIWLELKVTLKPEQADGLI 659
            |             |......:.|:  |:||.:.   :..|...:.:|.  |..|..|   :||:
Human  2296 G-------------CFGSSQNEDPSFHFDGSGYSVVEKSLPATVTQIIM--LFNTFSP---NGLL 2342

  Fly   660 LYSGPEHRGDFIALYLNDGFVEFAFDLGSGPALVRSEHSLSLGQWHTIKISRTARLAVL------ 718
            ||.|.....||:::.|..|.|:...||||||..:.::...:.|.|:.|...|..:..||      
Human  2343 LYLGSYGTKDFLSIELFRGRVKVMTDLGSGPITLLTDRRYNNGTWYKIAFQRNRKQGVLAVIDAY 2407

  Fly   719 ----KVDKHQEVLTISSNGFWHLS-LDQN-LFVGGV--NHVDRLPLDLKYKPFFVGCIQRIDING 775
                |..|..|....||:    |: ||:: ::|||:  :.|.|..:..|   .|||||:.::|:.
Human  2408 NTSNKETKQGETPGASSD----LNRLDKDPIYVGGLPRSRVVRRGVTTK---SFVGCIKNLEISR 2465

  Fly   776 HSLGIVAEALGGSNIGNCPHACVARPCGPLAECVPQMESYECRCSIHNERCNKAAEVPPEQLPEL 840
            .:..::..:.|           |.:.|  |.|.:..:...:          ....|:||:.|   
Human  2466 STFDLLRNSYG-----------VRKGC--LLEPIRSVSFLK----------GGYIELPPKSL--- 2504

  Fly   841 ALHKSKVLETKDNGEAAKKVSGLAHKKHSKKHRNLHKPTPATSTTTSTTSTTTTTTEAPSERTEE 905
                                                .|......|.:||:::....         
Human  2505 ------------------------------------SPESEWLVTFATTNSSGIIL--------- 2524

  Fly   906 ATAGALSNEEIEDDIIFRLVQQQQQQKELKKQHQQTTTTAPATSTTSSGPSKAKPRLSGKHHASK 970
            |..|.                      :::|:..:.....|..|....|              ..
Human  2525 AALGG----------------------DVEKRGDREEAHVPFFSVMLIG--------------GN 2553

  Fly   971 HEHHLKP--NAAFTRKLSRLPT--------HYESFQTNPDSDILTFEDNNDWVTSLQQQEYGDAM 1025
            .|.|:.|  .....:.|...||        |..|...|.....:..::||.     .:.:.|..:
Human  2554 IEVHVNPGDGTGLRKALLHAPTGTCSDGQAHSISLVRNRRIITVQLDENNP-----VEMKLGTLV 2613

  Fly  1026 AASQVPLAFEDASPGTPRSSDNNEDDENAFVFDESLFDASDGTEEY-QRKQLAQDMKRIMSN--- 1086
            .:..:.::                   |.:|   ......:||... .|:.....:|.::.|   
Human  2614 ESRTINVS-------------------NLYV---GGIPEGEGTSLLTMRRSFHGCIKNLIFNLEL 2656

  Fly  1087 --SNAHSSHKKAEVQFPPQGSQEVGTANEDTSQYSD------DYNDDELLTPVMQGGEEVKLEQH 1143
              .|:...|::.::               ||...|:      |..|.:||.......|:..::..
Human  2657 LDFNSAVGHEQVDL---------------DTCWLSERPKLAPDAEDSKLLPEPRAFPEQCVVDAA 2706

  Fly  1144 TSSTPQTHTDWSLLKKFDLSAEHQSQVQGVRKNFGACFAGSDSYF--HYNDADTMSQVISYSIDL 1206
            ....|..|       :|.|:                    .:|:|  .:|.:     .:...:.:
Human  2707 LEYVPGAH-------QFGLT--------------------QNSHFILPFNQS-----AVRKKLSV 2739

  Fly  1207 NLRIKTHSENGVILWTGRQGTTEEHDDYLSLGIEQGYLHFRYDLGSGEVDIRFNGTKVSDGLWHR 1271
            .|.|:|.:.:|:|.:...|...    ||..|.:..|.|||.:|||.|...:. :...:|||.||.
Human  2740 ELSIRTFASSGLIYYMAHQNQA----DYAVLQLHGGRLHFMFDLGKGRTKVS-HPALLSDGKWHT 2799

  Fly  1272 VRAIRNSQEGYLEVDGRKTVTLRAPGKLRQLNTDTGLYVGGMPD------VGYFTHQRYFSGIVG 1330
            |:.....::|::.||||::..:...|....|:.:...|:||:|.      :|..||     .|..
Human  2800 VKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEGLFYLGGLPSQYQARKIGNITH-----SIPA 2859

  Fly  1331 CISEIVL 1337
            ||.::.:
Human  2860 CIGDVTV 2866

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SP2353NP_611082.2 FXa_inhibition 53..82 CDD:464251 5/28 (18%)
LamG 404..555 CDD:238058 34/170 (20%)
EGF 583..612 CDD:394967 5/28 (18%)
LamG 625..774 CDD:238058 49/165 (30%)
LamG 1205..1340 CDD:214598 40/139 (29%)
LAMA1NP_005550.2 LamNT 16..268 CDD:214532
EGF_Lam 270..317 CDD:238012
Laminin_EGF 397..456 CDD:395007
Laminin_EGF 454..500 CDD:395007
LamB 563..695 CDD:214597
EGF_Lam 741..789 CDD:238012
Laminin_EGF 791..846 CDD:395007
EGF_Lam 848..900 CDD:238012
Laminin_EGF 902..948 CDD:395007
Laminin_EGF 951..998 CDD:395007
Laminin_EGF 998..1041 CDD:395007
Laminin_EGF 1044..1092 CDD:395007
Laminin_EGF 1090..1147 CDD:395007
Laminin_B 1218..1344 CDD:459652
Laminin_EGF 1403..1449 CDD:395007
Laminin_EGF 1452..1506 CDD:395007
Laminin_EGF 1509..>1546 CDD:395007
Laminin_I 1575..1830 CDD:310534
Tar 1763..>2102 CDD:440602 63/363 (17%)
Laminin_II 2011..2145 CDD:368703 33/215 (15%)
LamG 2141..2280 CDD:214598 37/181 (20%)
LamG 2307..2463 CDD:238058 49/167 (29%)
Laminin_G_1 2514..2658 CDD:395008 27/215 (13%)
Laminin_G_1 2743..2872 CDD:395008 39/134 (29%)
LamG 2892..3043 CDD:238058
Blue background indicates that the domain is not in the aligned region.

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