DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SP2353 and Sspo

DIOPT Version :9

Sequence 1:	NP_001286474.1	Gene:	SP2353 / 36771	FlyBaseID:	FBgn0034070	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	XP_017177063.1	Gene:	Sspo / 243369	MGIID:	2674311	Length:	5197	Species:	Mus musculus

Alignment Length:	1178	Identity:	226/1178 - (19%)
Similarity:	320/1178 - (27%)	Gaps:	453/1178 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SSLSSASIAVGAIPEPEEAAFQGHCGHTSPCEQLCYEIHDGMYEC-----------DCIEGYELN 76
            |||.:|       |.|     .|.....|||..|.::.:.|  ||           ||.:|.:..
Mouse  1587 SSLDTA-------PSP-----VGSTSPASPCSLLEFQCNSG--ECTPRGWRCDQEEDCTDGSDEL 1637

  Fly    77 KNGYSC-----------------QVINATSNSLDGRGKSDEDVLYQKGASFSAKLANDDGGKSMA 124
            ..|..|                 |:.:..:...||   ||||.
Mouse  1638 DCGGPCMLYQVPCAHSPHCVSPGQLCDGVTQCPDG---SDEDP---------------------- 1677

  Fly   125 KSTFALSAAQSASPAGNENG---EDESGSEGDSYDYGELEDSNSETQEQKQKSLNLQQQ------ 180
                .:...||||...|..|   .:.|..:|...|:..:.|.|.:.:...:...:|.:|
Mouse  1678 ----DVCEEQSASGGANRTGAPCPEFSCPDGTCIDFLLVCDGNPDCELADETEPSLDEQGCGAWG 1738

  Fly   181 ---------QQQQQKVNSNDYYISAESINFNSESEGQEQQDVADFKAASTM---LPSSVPPTPSR 233
                     |.......|.:...|..|:.......|.:.|..|.|..|..:   ..|..|.:|
Mouse  1739 SWGPWAPCSQTCGSGTRSRNRNCSTSSLQVLQNCPGLQHQSQACFTEACPVDGEWSSWSPWSP-- 1801

  Fly   234 STTRATASTTTTTTTTRRSPTRAPKQRVDVDYGEGDGSDDYSYSYKSDMSVYDDVNNNQLNLRRN 298
                  .|.....||||....|.|:          :|..|.:.
Mouse  1802 ------CSEPCGGTTTRHRQCRPPQ----------NGGQDCAL---------------------- 1828

  Fly   299 SKSQTYQQTSNTNTAKNRRKYPNVTSNKVQMHITRETNRLENISAAEPAVVGAAMTTDRSTPTCN 363
                                .|..|      |.||:|:.............|..:.  |:...|.
Mouse  1829 --------------------LPGST------HSTRQTSPCPQEGCLNATCFGELVF--RTCAPCP 1865

  Fly   364 LDC---GSDGICALEATAASSRCLCPFGKTGNGCQEDIRAHVPRFAKRSWLAFPALHGAYKHVQL 425
            |.|   .....|..:...:|..|.||.||..|...:.:|   ||       ..|.|
Mouse  1866 LTCDDISGQAACPPDRPCSSPGCWCPDGKVLNTEGQCVR---PR-------QCPCL--------- 1911

  Fly   426 RIEFRPESFDGIILLSGERDDLTGDFMALLLNKG-------FVEFWFDCGSGVGSVRSRETILLN 483
                    .||.....|:|  :..|........|       ..|...|||
Mouse  1912 --------VDGAHYWPGQR--IKMDCQLCFCQDGQPHRCRPNPECAVDCG--------------- 1951

  Fly   484 EWNSVIIYRHRWDAWLVLNHGTKVQGRSNGLFSRITFREP--VFLGGIG----NITGLAKRLPLA 542
             |:|       |..|      .:..|..:....:.:||.|  ..|.|.|    .|...|:|.. .
Mouse  1952 -WSS-------WSPW------AECLGPCSSQSLQWSFRSPNNPRLSGHGRQCRGIHRKARRCQ-T 2001

  Fly   543 EGFAGCIRRFVANEHDYKFTEHPLGDVINGFDIQDCSTDKCVRYPCQHGGKCLPSDQGAICLCPI 607
            |...||.:..:.    |...|...|.        .|...:|:.....|   |.|       .|||
Mouse  2002 EACEGCEQWGLM----YNVGERWRGG--------PCMVCECLHSSITH---CSP-------YCPI 2044

  Fly   608 GF----------VGDLC-----------EIRMDLQVPAFNGSSFLRYAPLGDSALIWLELKVTLK 651
            |.          :|:.|           .|.|....||      ...||   |..|...|...:.
Mouse  2045 GSCPQGWVLVEGMGESCCHCALPEKNQTVIHMTTPAPA------PASAP---SPQIGAHLVTYVL 2100

  Fly   652 PEQAD---------GLILYSGPEH-----RGDFIALYLNDGFVEFAFDLGSGPALVRSEHSLSLG 702
            |..||         ||.:::..:|     |.|.:...:          .|.||....|      .
Mouse  2101 PPTADACYSPLGLAGLPMWAPSQHWEHITRADPVEAPM----------AGPGPREGAS------A 2149

  Fly   703 QWHT------IKISRTARLAVLKVDK------HQEVLTI---SSNGFWHLSLDQNLFVGGVNHVD 752
            :|||      :.:.|...|..:.|.:      :...|::   |.|..||            |:|:
Mouse  2150 EWHTQPLYLQLDLRRPRNLTGIIVQRAGSSAAYVSTLSLQFSSDNLQWH------------NYVN 2202

  Fly   753 RLPLDL---KYKP-----------FFVGCIQ----RI--------DINGHSLGIVAEALGGSNIG 791
            .|...|   |..|           .|...:|    |:        |.|.|.:.:..|.||
Mouse  2203 SLSSTLSPPKPSPESSNHMAPEVWTFDQMVQARYIRVWPHSGHLRDNNQHDIFLWVELLG----- 2262

  Fly   792 NCPHACVARPCGPLAECVPQMESYEC---RCSIHNERCNKAAEVPPEQLPELALHKSKVLETKDN 853
                 |......|||...|. ..:.|   .|:.....|:.|.:.                   |:
Mouse  2263 -----CKPGTVSPLAPLCPG-SRHRCASGECAPKGGPCDGAVDC-------------------DD 2302

  Fly   854 GEAAKKVSGLAHKKHSKKHRNLHKPTPATSTTTSTTSTTTTTTEAPSERTEEATAGALSNEEIED 918
            |...:...            :||     .|||:.....|.|...:|::      .|....|.:.|
Mouse  2303 GSDEEGCG------------SLH-----ASTTSRVHPMTRTPALSPTQ------PGKFPREGLPD 2344

  Fly   919 DIIFRLVQQQQQQKELKKQHQQTTTTAPATSTTSSGPSKAKPRLSGKHHASKH-EHHLKPNAAFT 982
                ...||.:|:..|....|...|    .|.||:.|..||....|....:.| .|.:.|.|...
Mouse  2345 ----TEPQQPKQESSLPGAGQPMQT----LSATSTFPPGAKSLHPGMAAVTVHPPHSVTPGAPVG 2401

  Fly   983 RKLSRLPTHYESFQTNPDS---DIL-------TFEDNNDWVTSLQQQEYGDAMAASQVPLAF-ED 1036
            :.:|  |..:......|..   |:|       ..:...|.:....:|.     .||..|... ..
Mouse  2402 QTVS--PRPFPPMPCGPGQVPCDVLGCVEQEQLCDGREDCLDGSDEQH-----CASAEPFTVPTT 2459

  Fly  1037 ASPGTPRS 1044
            |.||.|.|
Mouse  2460 ALPGLPAS 2467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SP2353	NP_001286474.1	FXa_inhibition	53..82	CDD:291342	9/39 (23%)
		LamG	404..555	CDD:238058	30/163 (18%)
		EGF	583..612	CDD:278437	8/38 (21%)
		LamG	625..774	CDD:238058	38/203 (19%)
		LamG	1205..1340	CDD:214598
Sspo	XP_017177063.1	VWD	229..378	CDD:214566
		C8	434..505	CDD:370094
		TIL	509..564	CDD:366828
		VWD	593..753	CDD:214566
		C8	791..863	CDD:214843
		TIL	866..919	CDD:366828
		VWD	1054..1201	CDD:365869
		C8	1245..1311	CDD:370094
		TIL	1315..1371	CDD:366828
		LDLa	1416..1451	CDD:238060
		LDLa	1456..1490	CDD:238060
		LDLa	1492..1526	CDD:238060
		LDLa	1532..1563	CDD:197566
		Ldl_recept_a	1603..1639	CDD:365841	10/37 (27%)
		TSP1	1737..1788	CDD:214559	9/50 (18%)
		TIL	1857..1908	CDD:366828	15/62 (24%)
		TSP1	1952..2005	CDD:214559	15/66 (23%)
		FA58C	<2142..2262	CDD:330301	27/137 (20%)
		LDLa	2275..2309	CDD:238060	7/53 (13%)
		LDLa	2414..2448	CDD:238060	5/38 (13%)
		LDLa	2471..2505	CDD:238060
		TSP1	2565..2617	CDD:214559
		TIL	2640..2682	CDD:366828
		TSP1	2725..2774	CDD:214559
		TSP_1	2841..2889	CDD:365867
		TIL	2893..2952	CDD:366828
		VWC_out	2954..3001	CDD:214565
		TSP1	2994..3045	CDD:214559
		TIL	3097..3149	CDD:366828
		TSP1	3193..3256	CDD:214559
		TSP1	3262..3314	CDD:214559
		TIL	3322..3372	CDD:366828
		TSP1	3418..>3458	CDD:214559
		TSP1	3482..3526	CDD:214559
		TIL	3536..3592	CDD:366828
		TSP1	3655..3699	CDD:214559
		TSP1	3832..3884	CDD:214559
		TSP1	3901..3949	CDD:214559
		TSP1	3967..4020	CDD:214559
		TSP1	4025..4077	CDD:214559
		TIL	4080..4135	CDD:366828
		TSP1	4180..4230	CDD:214559
		TSP1	4274..4325	CDD:214559
		TSP1	4389..4440	CDD:214559
		TIL	4444..4499	CDD:366828
		TSP1	4639..4687	CDD:214559
		TIL	4701..4747	CDD:366828
		TSP1	4791..4840	CDD:214559
		TIL	4842..4896	CDD:366828
		TIL	4948..5006	CDD:366828
		VWC	5008..5063	CDD:327433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3509
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900