DRSC/TRiP Functional Genomics Resources

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Protein Alignment SP2353 and LAMB4

DIOPT Version :10

Sequence 1:NP_611082.2 Gene:SP2353 / 36771 FlyBaseID:FBgn0034070 Length:1361 Species:Drosophila melanogaster
Sequence 2:XP_011514277.1 Gene:LAMB4 / 22798 HGNCID:6491 Length:1772 Species:Homo sapiens


Alignment Length:844 Identity:157/844 - (18%)
Similarity:251/844 - (29%) Gaps:300/844 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   321 NVTSNKVQMHITRETNR-LENISAA-----EPAVVGAAMTTDRSTPTC-NLDCGSDGICALEATA 378
            :||..:....:|.|..| |.|...|     :|...|:|:     ..|| ...|.:.|:..:|...
Human   977 DVTDPESCSRVTGECLRCLHNTQGANCQLCKPGHYGSAL-----NQTCRRCSCHASGVSPMECPP 1036

  Fly   379 ASSRCLC----------PFGKTGNGCQEDIRAHVPRFAKRSWLAFPALHGAYKHVQLRIEFRPES 433
            ....|||          | ..||..|.        |.|...|...|. .|...     .:..|.:
Human  1037 GGGACLCDPVTGACPCLP-NVTGLACD--------RCADGYWNLVPG-RGCQS-----CDCDPRT 1086

  Fly   434 FDGIILLSGERDDLTGDFMALLLNKGFVEFWFDCGSGVGSVRSRETILLNEWNSVIIYRHRWDAW 498
            ..     |...|.|||.              ..|..|.|..|..|   ..|              
Human  1087 SQ-----SSHCDQLTGQ--------------CPCKLGYGGKRCSE---CQE-------------- 1115

  Fly   499 LVLNHGTKVQGRSNGL-FSRITFREPVFLGGIGNITGLAKRLPLAEGFAGCIRRFVANEHDYKFT 562
               |:.....||.... .:|...::|:    ....||:.:   ..||.:|               
Human  1116 ---NYYGDPPGRCIPCDCNRAGTQKPI----CDPDTGMCR---CREGVSG--------------- 1155

  Fly   563 EHPLGDVINGFDIQDCSTDKCVRYPCQHGGKCLPSDQGAIC------------------------ 603
                         |.|  |:|.|...|....||   |..:|                        
Human  1156 -------------QRC--DRCARGHSQEFPTCL---QCHLCFDQWDHTISSLSKAVQGLMRLAAN 1202

  Fly   604 ---------LCPIGFV---GDLCEIRMDLQVPAFNGSSFLRYAPLGDSA---LIWL--------- 644
                     :|...|.   |::.||...|:.|.|....||:.....||.   ::.|         
Human  1203 MEDKRETLPVCEADFKDLRGNVSEIERILKHPVFPSGKFLKVKDYHDSVRRQIMQLNEQLKAVYE 1267

  Fly   645 --ELKVTLKPEQADGLILYSGPEHRGDFIALYLNDGFVEFAFDLGSGPALVRSEHSLSLGQWHTI 707
              :||.|::..:.:..:|....:...|..:..||....:      |...:.:..|..|..:   .
Human  1268 FQDLKDTIERAKNEADLLLEDLQEEIDLQSSVLNASIAD------SSENIKKYYHISSSAE---K 1323

  Fly   708 KISRTARLAVLKVDKHQEVLTI----SSNGFWHLSLDQNLFVGGVNHVDRLPLDLKYKPFFVGCI 768
            ||:.|:.......:...::|||    :|.|  :|||::                          :
Human  1324 KINETSSTINTSANTRNDLLTILDTLTSKG--NLSLER--------------------------L 1360

  Fly   769 QRIDINGHSLGIVAEALGGSNIGNCPHACVARPCGPLAECVPQMESYECR---C----SIHNERC 826
            ::|.|  ..:.|:.|.:.| :.||.|  ||..|||. |.|..:....:||   |    ::.....
Human  1361 KQIKI--PDIQILNEKVCG-DPGNVP--CVPLPCGG-ALCTGRKGHRKCRGPGCHGSLTLSTNAL 1419

  Fly   827 NKAAEVP------PEQLPELALHKSKVLETKDNGEAAK--------KVSGLAHKKHS-------- 869
            .||.|..      .:|:..|   |:::....:..|.:|        |:..:.::..|        
Human  1420 QKAQEAKSIIRNLDKQVRGL---KNQIESISEQAEVSKNNALQLREKLGNIRNQSDSEEENINLF 1481

  Fly   870 -KKHRN---------------------LHKPTPATSTTTSTTSTTTTTTEAPSERTEEATAGALS 912
             ||.:|                     :|.|.|:.:.|................||:|...    
Human  1482 IKKVKNFLLEENVPPEDIEKVANGVLDIHLPIPSQNLTDELVKIQKHMQLCEDYRTDENRL---- 1542

  Fly   913 NEEIED---------------DIIFRLVQQQQQQKELKKQHQQTTTTAPATST----TSSGPSKA 958
            |||.:.               :|:..|      .|.|.:..|...|...|.||    |::.....
Human  1543 NEEADGAQKLLVKAKAAEKAANILLNL------DKTLNQLQQAQITQGRANSTITQLTANITKIK 1601

  Fly   959 KPRLSGKHHASKHEHHL---KPNAAFTRKLSRLPTHYESFQTNPDSDILTFEDNNDWVTSLQQQ 1019
            |..|..::...:.:..|   |..:.....||.|.|..:..|.:..:..:..|.......||:::
Human  1602 KNVLQAENQTREMKSELELAKQRSGLEDGLSLLQTKLQRHQDHAVNAKVQAESAQHQAGSLEKE 1665

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SP2353NP_611082.2 FXa_inhibition 53..82 CDD:464251
LamG 404..555 CDD:238058 27/151 (18%)
EGF 583..612 CDD:394967 9/64 (14%)
LamG 625..774 CDD:238058 28/166 (17%)
LamG 1205..1340 CDD:214598
LAMB4XP_011514277.1 Laminin_N 28..263 CDD:459653
EGF_Lam 264..320 CDD:238012
Laminin_EGF 332..382 CDD:395007
Laminin_EGF 395..452 CDD:395007
EGF_Lam 454..503 CDD:238012
EGF_Lam 505..549 CDD:238012
EGF_Lam 768..809 CDD:238012
Laminin_EGF 822..865 CDD:395007
EGF_Lam 862..909 CDD:238012
Laminin_EGF 970..>1012 CDD:395007 9/34 (26%)
Laminin_EGF 1033..1077 CDD:395007 12/53 (23%)
Laminin_EGF 1080..1128 CDD:395007 15/86 (17%)
EGF_Lam 1127..>1165 CDD:238012 12/74 (16%)
Mplasa_alph_rch 1254..>1714 CDD:275316 85/468 (18%)
Blue background indicates that the domain is not in the aligned region.

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