DRSC/TRiP Functional Genomics Resources

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Protein Alignment SP2353 and unc-52

DIOPT Version :9

Sequence 1:NP_001286474.1 Gene:SP2353 / 36771 FlyBaseID:FBgn0034070 Length:1361 Species:Drosophila melanogaster
Sequence 2:NP_001364664.1 Gene:unc-52 / 175126 WormBaseID:WBGene00006787 Length:4075 Species:Caenorhabditis elegans


Alignment Length:1420 Identity:293/1420 - (20%)
Similarity:483/1420 - (34%) Gaps:450/1420 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 GMYECDCIEGYELNKNGYSCQVINA--TSNSLDGRGKSDEDVLY---QKGASFSAKLANDDGGKS 122
            |:|.|: :|    :.||.   ||.:  |:.|:..:.||...::.   :..|||:..:.:..|.| 
 Worm  2938 GVYRCN-VE----DNNGL---VIGSAFTAVSVGQQDKSHAQIVKFDDKSDASFTCPIYSVPGSK- 2993

  Fly   123 MAKSTFALSAAQSASPAGNENGE--DESGSEGDSYDYGELEDSNSETQEQKQKSLNLQQQQQQQQ 185
             ...|:             |||:  .::...|:..:..|.:|:::.|...|...           
 Worm  2994 -VDWTY-------------ENGDLPSKAVPNGNKIEIKEFDDASAGTYVCKVSF----------- 3033

  Fly   186 KVNSNDYYISAE--------SINFNSESEGQEQQDVADFKAASTMLPSSV-----------PPTP 231
            ..|..:.:::|:        .:.....||..:..|.|.|....|..||:|           ||..
 Worm  3034 DGNVVEGFVTAQMFVPDTIIQVLLEVSSESPQIGDRAWFDCKVTGDPSAVISWTKEGNDDLPPNA 3098

  Fly   232 SRSTTRA--------TASTTTTTTTTRRSPTRAPKQRVDVDYGEGDGSDDYSYSYKSDMSVYDDV 288
            ..:..|.        .|........|:..|.:.   |..::.|.|. .|..:::....:.|.   
 Worm  3099 QVTGGRLLFTDLKEDNAGVYRCVAKTKAGPLQT---RTVLNVGSGK-QDQVTFTVADSLPVV--- 3156

  Fly   289 NNNQLNLRRNSKSQTYQQTSNTNTAKNRRKYPNVTSNKVQMHITRETNRLENISAAEPAV--VGA 351
                         .|..|.:..:........||.:     :..|:|...|.:.|..|..|  :.:
 Worm  3157 -------------YTVGQPAYLSCIGKTETKPNQS-----VVWTKEEGDLPSGSRVEQGVLMLPS 3203

  Fly   352 AMTTDRSTPTCNLDCGSDGICALEATAASSRCLCPFGKTGNGCQEDIRAHVPRFAKRSWLAFPAL 416
            ....|..:.||.:                       .|..|.....:...:..|       .|.:
 Worm  3204 VHRDDEGSYTCEI-----------------------VKEENPVFSTVDLQIDDF-------IPVI 3238

  Fly   417 HGAYKHVQLRIEFRPESFDGIILLSGE---------------RDDLTGDFMAL----------LL 456
            .|.      .||..|.|.:.|:.|..|               :...:||.:|.          :.
 Worm  3239 DGE------PIELPPLSDEEIVNLDIEITLNTANPKGIIFETKRINSGDLLATPYDTIHHEAKIT 3297

  Fly   457 NKGFVEFWFDCGSGVGSVRSRETILLNEWNSVIIYRHRWDAWLVLN-HGTKVQGRSNGLFSRIT- 519
            :.|.|.:.||.|:|...|.:...|..||||.:.|...:....:.|| ....::..:|.|.|..| 
 Worm  3298 DYGTVLYEFDIGNGRQIVETTNPINPNEWNVIKIKNDKNQVTIQLNDESATIRQHTNPLPSLSTG 3362

  Fly   520 FREPVFLGGIGNITGLAKRLPLAEGFAGCIRRFVANEHDYKFTEHPLGDVINGFDIQDC-STDKC 583
            ...|||:||....|.      .|..|.|.|.:.|.:.|:....:..:...:..:|.  | ||:.|
 Worm  3363 VNRPVFIGGRHEPTN------EANDFRGIISQVVLSGHNVGLGDARIPSSVVKYDA--CASTNLC 3419

  Fly   584 VR------------YPCQ-----HG-----------------GKCLPSDQGAICLCPIGFVGDLC 614
            :.            :.|:     ||                 |.||.:::...|:||:|..|..|
 Worm  3420 LNGANCRNANNHHGFSCECAEEFHGEYCQWRSNSCHDESCNTGICLDNEESWQCVCPLGTTGLRC 3484

  Fly   615 EIRMDLQVPA--FNGSSFLRYAPLGDSALIWLELKVTLKPEQADGLILYSGPEHRGDFIALYLND 677
            |.:.::..|.  .:.:|||..    ...:.:..:|:.|:| |||      ..||    |.:|   
 Worm  3485 EEKTEIPQPLGFTSDTSFLAV----KRPVKFESIKMKLRP-QAD------SDEH----ILMY--- 3531

  Fly   678 GFVEFAFDLGSGP------------------------ALVRSEHSLSLGQWHTIKISRTARLAVL 718
                ||.|.||..                        ..:||| :|..|:...:.:.:.....|:
 Worm  3532 ----FASDYGSNTKQYTSLSLIANQVVLTVRRPDKEVQKIRSE-TLEAGELIDVAVRQAGNALVM 3591

  Fly   719 KVDKHQEVLTISSNGFWHLSLDQNLFVGGVNHVDRLPLDLKYKPFFVGCIQRIDINGHSLGIVAE 783
            .||.:| |.||.::   .|.....:|:||:......|.|: .:..|.||:..|.||...:.:   
 Worm  3592 TVDGNQ-VSTIETD---TLKPGTEIFIGGLPPGLNSPDDV-VEQSFQGCVYEILINSQDVDL--- 3648

  Fly   784 ALGGSNIGNCPHACVARPCGPLAECVPQMESYECRCSIHNERCNKAAEVPPEQLPELALHKSKVL 848
                .|:.:         .|.::.|                   :.::.|.|:            
 Worm  3649 ----QNLSS---------SGDISSC-------------------EESQFPVEE------------ 3669

  Fly   849 ETKDNGEAAKKVSGLAHKKHSKKHRNLHKPTPATSTTTSTTSTTTTTTEAPSERTEEATAGALSN 913
                                                   ..:|||||||.|....||.|     .
 Worm  3670 ---------------------------------------DDTTTTTTTEEPEAVIEEPT-----T 3690

  Fly   914 EE---IEDDIIFRLVQQQQQQKELKKQHQQTTTTAPATSTTSSGPSKAKPRLSGKHHASKHEHHL 975
            ||   .|:.|.....::....:|.....:.||||...|:||:..|                    
 Worm  3691 EEPTTTEEPITEEPTEEPTTTEEPTTTEEPTTTTEEPTTTTTEEP-------------------- 3735

  Fly   976 KPNAAFTRKLSRLPTHYESFQTNPDSD---ILTFEDNNDWVTSLQQQEYGDAMAASQVPLAFEDA 1037
                            |..::|:.|.|   |:..|......|:....|..:|..|..:|      
 Worm  3736 ----------------YHIYETSRDDDPEIIIPVETTTTSTTTTSTTEEPEAEPALVLP------ 3778

  Fly  1038 SPGTPRSSDNNEDDENAFVFDESLFDASDGTEEYQRKQLAQDMKRIMSNSNAHSSHKKAEVQFPP 1102
                     .:..:||         |.||..||      ...:..:..::...|....:|...||
 Worm  3779 ---------TDPVEEN---------DVSDEEEE------ISTISTVSPDNGLDSDSDYSEGTLPP 3819

  Fly  1103 QGSQE---VGTANEDTSQYSDDYNDDELLTPVMQGGEEVKLEQHTSSTPQTHTD---WSLLKKFD 1161
            ..|.|   ||    |.....:..|.....|..|.|....:...|.:...:.:.|   .||.|.. 
 Worm  3820 DSSSEEIVVG----DVYSTQEPNNICANSTCGMNGQCVPRNMTHYTCECKLYYDGPTCSLFKPI- 3879

  Fly  1162 LSAEHQSQVQGVRKNFGACF--AGSDSYFHYNDADTMSQVISYSIDLNLRIKTHSENGVILWTGR 1224
               ||.::..      |..|  ..||.:.|.  .....:::::      :.||..:|||:||.|:
 Worm  3880 ---EHAARFD------GDAFIELSSDEFPHL--TSEKDEIVAF------KFKTEQQNGVLLWQGQ 3927

  Fly  1225 QGTTEEHDDYLSLGIEQGYLHFRYDLGSGEVDIRFNGTKVSDGLWHRVRAIRNSQEGYLEVDGRK 1289
            :.|.::.:||:|:||..|:|||.|:||.|...: .:..:|.||..|.||..|..:||.:.:|..:
 Worm  3928 RPTVQQMEDYISVGIVNGHLHFSYELGGGAAHL-ISEERVDDGKEHSVRFERKGREGQMRIDNYR 3991

  Fly  1290 TVTLRAPGKLRQLNTDTGLYVGGMPDVGYFTHQRYFSGIVGCISEIVLAGEMKLN 1344
            .|..|:.|.|..||.|..::|||:||:...|...:.:..||||:::.|.| :||:
 Worm  3992 EVDGRSTGILAMLNVDGNIFVGGVPDISKATGGLFSNNFVGCIADVELNG-VKLD 4045

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SP2353NP_001286474.1 FXa_inhibition 53..82 CDD:291342 6/18 (33%)
LamG 404..555 CDD:238058 43/177 (24%)
EGF 583..612 CDD:278437 11/62 (18%)
LamG 625..774 CDD:238058 40/172 (23%)
LamG 1205..1340 CDD:214598 50/134 (37%)
unc-52NP_001364664.1 LDLa 125..156 CDD:238060
IG <193..264 CDD:214652
LDLa 275..309 CDD:238060
LDLa 314..349 CDD:238060
LDLa 416..450 CDD:238060
LDLa 498..535 CDD:238060
LDLa 564..599 CDD:238060
LDLa 752..786 CDD:238060
IgI_Perlecan_like 834..919 CDD:409412
Ig strand B 851..855 CDD:409412
Ig strand C 867..871 CDD:409412
Ig strand E 886..890 CDD:409412
Ig strand F 900..905 CDD:409412
Ig strand G 913..916 CDD:409412
Ldl_recept_a 937..972 CDD:395011
LDLa 977..1013 CDD:412164
Ldl_recept_a 1020..1057 CDD:395011
Ig_Perlecan_like 1075..1152 CDD:143220
Ig strand B 1078..1082 CDD:143220
Ig strand C 1091..1095 CDD:143220
Ig strand E 1116..1120 CDD:143220
Ig strand F 1130..1135 CDD:143220
Ig strand G 1144..1147 CDD:143220
EGF_Lam 1172..1218 CDD:214543
LamB 1286..1413 CDD:214597
Laminin_EGF <1477..1511 CDD:395007
LamB 1578..1702 CDD:214597
Laminin_EGF 1748..1795 CDD:395007
Laminin_EGF 1804..1851 CDD:395007
IG 1932..2012 CDD:214652
IG_like 2023..2104 CDD:214653
Ig strand A' 2025..2029 CDD:409353
Ig strand B 2032..2042 CDD:409353
Ig strand C 2047..2054 CDD:409353
Ig strand C' 2055..2058 CDD:409353
Ig strand E 2067..2073 CDD:409353
Ig strand F 2080..2088 CDD:409353
Ig 2118..>2181 CDD:416386
Ig strand A' 2122..2126 CDD:409353
Ig strand B 2129..2139 CDD:409353
Ig strand C 2144..2151 CDD:409353
Ig strand C' 2152..2155 CDD:409353
Ig strand E 2163..2170 CDD:409353
IG 2212..2293 CDD:214652
IG 2303..2383 CDD:214652
IG_like 2404..2486 CDD:214653
Ig strand A' 2406..2409 CDD:409353
Ig strand B 2413..2423 CDD:409353
Ig strand C 2430..2434 CDD:409353
Ig strand C' 2436..2438 CDD:409353
Ig strand D 2444..2449 CDD:409353
Ig strand E 2450..2456 CDD:409353
Ig strand F 2463..2470 CDD:409353
IG 2499..2579 CDD:214652
Ig 2598..2671 CDD:416386
Ig strand B 2601..2610 CDD:409353
Ig strand C 2615..2622 CDD:409353
Ig strand C' 2624..2627 CDD:409353
Ig strand F 2650..2658 CDD:409353
Ig strand G 2661..2671 CDD:409353
Ig_3 2673..2756 CDD:404760
Ig strand B 2694..2698 CDD:409353
Ig strand C 2710..2713 CDD:409353
Ig strand E 2736..2740 CDD:409353
Ig strand F 2750..2755 CDD:409353
Ig strand G 2763..2766 CDD:409353
IG 2880..2955 CDD:214652 8/24 (33%)
Ig 2970..3043 CDD:416386 15/98 (15%)
Ig strand A' 2971..2974 CDD:409353 0/2 (0%)
Ig strand B 2978..2987 CDD:409353 3/8 (38%)
Ig strand C 2993..2997 CDD:409353 1/5 (20%)
Ig strand C' 2999..3001 CDD:409353 1/1 (100%)
Ig strand D 3006..3011 CDD:409353 0/4 (0%)
Ig strand E 3012..3018 CDD:409353 0/5 (0%)
Ig strand F 3025..3033 CDD:409353 2/7 (29%)
Ig strand G 3036..3043 CDD:409353 1/6 (17%)
Ig 3067..3137 CDD:416386 14/72 (19%)
Ig strand B 3070..3077 CDD:409353 2/6 (33%)
Ig strand C 3083..3088 CDD:409353 1/4 (25%)
Ig strand D 3097..3101 CDD:409353 0/3 (0%)
Ig strand E 3103..3107 CDD:409353 1/3 (33%)
Ig strand F 3116..3124 CDD:409353 0/7 (0%)
Ig strand G 3127..3137 CDD:409353 2/12 (17%)
IG 3154..3231 CDD:214652 16/120 (13%)
LamG 3257..3394 CDD:214598 34/142 (24%)
EGF_CA 3411..3448 CDD:238011 8/38 (21%)
LamG 3513..3644 CDD:214598 39/154 (25%)
LamG 3882..4040 CDD:238058 54/172 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 108 1.000 Domainoid score I4038
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D17288at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.920

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