Protein Alignment SP2353 and Lamb3

DIOPT Version :10

• Sequence 1: NP_611082.2
• Gene: SP2353 / 36771
• FlyBaseID: FBgn0034070
• Length: 1361
• Species: Drosophila melanogaster
• Sequence 2: NP_032510.2
• Gene: Lamb3 / 16780
• MGIID: 99915
• Length: 1168
• Species: Mus musculus
• Alignment Length: 1276
• Identity: 239/1276 - (18%)
• Similarity: 397/1276 - (31%)
• Gaps: 396/1276 - (31%)

  Fly    47 CGHTSPCEQLCYEIHDGMYECDCIEGYELNKNGYSCQVINATSNSLDGR-GKSDEDVLYQKGASF 110
            ||.|.| |..|.:......:| |.....|.:|..|.:|.|..|:|...| .:|..||     :..
Mouse    47 CGLTKP-ETYCTQYGQWQMKC-CKCDSRLPRNYNSHRVENVASSSGPMRWWQSQNDV-----SPV 104

  Fly   111 SAKLANDDGGKSMAKSTFALSAAQSASPAGN--ENGEDESGSEGDSYDYGELEDSNSETQEQKQK 173
            |.:|   |..|.|......:. .:..:|||.  |...| .|.....|.|...:.:::..|..:.:
Mouse   105 SLQL---DLDKRMQLQDIMMD-FKGLTPAGMLIERSSD-FGKTWRVYQYLATDCASTFPQVHQGQ 164

  Fly   174 SLNLQQQQQQQQKVNSNDYYISAESINFNSESEGQEQQDVADFKAASTMLPSSVPPTPSRSTTRA 238
            ..|.|..:.:......|.:.           :.|:.|.::.|       |.|::|.:.|:.....
Mouse   165 PKNWQDVRCRPLSQRPNGHL-----------TGGKVQLNLMD-------LASAIPASQSKKIQEL 211

  Fly   239 TASTTTTTTTTRRSPTRAPKQRVDVDYGEGDGSDDYSYSYKSDMSVYDDVNNNQLNLRRN----- 298
            ...|......|:.:|  .|::.              ||...:..:|      :||.|:.:
Mouse   212 GDITNLRVNFTKLAP--VPQRG--------------SYPPSAYFAV------SQLRLQGSCFCHG 254

  Fly   299 ---------SKSQTYQQTSNTNTAKNRRKYPNVT------SNK----VQMHITRETNRLENISAA 344
                     ..|.|..|.:|....::....||..      :|:    .:...|.|..|.:....:
Mouse   255 HADRCAPNPGGSTTAVQVNNVCVCQHNTAGPNCDRCAPFYNNRPWRPAEGQDTHECQRCDCNGHS 319

  Fly   345 E-----PAVVGAAMTTDRSTPTCNLDCGSDGICALEATAASSRCLCPFGKTGNGCQEDIRAHVPR 404
            |     |||..|:..|            :.|:|.          .|.....|..|:   |..:..
Mouse   320 ETCHFDPAVFAASQGT------------NGGVCD----------NCRDHTEGKNCE---RCQLHY 359

  Fly   405 FAKRSWLAFPALHGAYKHVQLRIEFRPESFDGIILLSGERDDLTGDFMALLLNKGFVEFWFDCGS 469
            |..|...|  .:|    ...:..|..|   ||.: .....|.|||                .|
Mouse   360 FRNRRPSA--PIH----ETCIPCECDP---DGAV-QGAPCDRLTG----------------QC-- 396

  Fly   470 GVGSVRSRETILLNEWNSVIIYRHRWDAWLVLNHGTKVQGRSNGL----FSRITFREPVFLGGIG 530
                       :..|:                     |||....|    |:.:||..|.......
Mouse   397 -----------VCKEY---------------------VQGERCDLCKPGFTGLTFANPKGCHACD 429

  Fly   531 -NITGLAKRLPLAE--GFAGCIRRFVANEHDYKFTEHPLGDVINGFDIQDCSTD-------KCVR 585
             :|.|..|.:|..|  |...|:...|..:.|.....|  ..:.:|...:.|:.|       :|.:
Mouse   430 CSILGARKDMPCEEETGRCLCLPNVVGPKCDQCAPSH--WKLASGLGCEPCACDPRNSLSSQCNQ 492

  Fly   586 Y----PCQHGGKCLPSDQGAICLCP---IGFVGDLCEIRMDLQVPAFNGSSFLRYAPLGDSALIW 643
            :    ||:.|...|.....||..||   .|.|...|. ..|..   |.|:.       |...
Mouse   493 FTGQCPCREGFGGLTCSSAAIRQCPDQTYGHVATGCR-ACDCD---FRGTE-------GPGC--- 543

  Fly   644 LELKVTLKPEQADGLIL----YSGPE----HRGDF----IALYLNDGFVEFAFDLGSGPALVRSE 696
                     ::|.|..|    ::||.    .||..    :.:..:..|..:..||......:.|.
Mouse   544 ---------DKASGRCLCRPGFTGPRCDQCQRGHCDRYPVCVACHSCFQAYDTDLQEQARRLHSL 599

  Fly   697 HSLSLGQW-------HTIKISRTARL--AVLKVDKHQEVLTISS----------NGFWHLSLDQN 742
            .:.:.|.|       |.:    .:||  |..|:::.:::|..:|          ||.  ||:.:.
Mouse   600 RNATEGLWTGTGLEDHGL----ASRLLDAKSKIEQIRQILEGTSVTEQDVAQVANGI--LSIRRT 658

  Fly   743 LFVGGVNHVDRLPLDLKYK---PFFVGCIQRIDINGHSLGIV-------AEALGGSNIGNCPHAC 797
            |        ..|||||..:   ..|.|.:..:|.:...|.::       .|.|...:
Mouse   659 L--------QGLPLDLPLEEEMESFSGDLGNLDRSFSRLLLMYRSKKEQFEKLSSED-------- 707

  Fly   798 VARPCGPLAECVPQMESYECRCSIHNERCNKAAEVPPEQLPELALHKSKVLETKDNGEAAKKVSG 862
               |.|...           ..::..|:.::||    :|:.:.:...|::.:::...|..::.:|
Mouse   708 ---PSGAFR-----------MLTMAYEQSSRAA----QQVSDSSSLLSQLRDSRREAEGLERQAG 754

  Fly   863 ---------LAHKKHSKKHRNLHKPTPATSTTTS-TTSTTTTTTEAPSE--RTEEATA------G 909
                     :|.:.......:|   ||..:.... :..|..|..:.|.|  ..:..||      |
Mouse   755 GGGTGGAQLMALRLEMASLPDL---TPTINKLCGRSRQTACTPGDCPGELCPQDNGTACGSHCRG 816

  Fly   910 ALSNEEIEDDIIFRLVQQQQQQKELKKQHQQTTTTAPATSTTSSGPSKAKPRLSGKHHASKHEHH 974
            ||...:....:..|:.   :|.:....|.|||.....|....:|.......||  :...|.....
Mouse   817 ALPRAKGAFHMAGRVA---EQLRNFNTQLQQTRQMIRAAEEAASRVQADAQRL--ETQVSTSRLL 876

  Fly   975 LKPNAAFTRKLSRLPTHYESFQTNPDSDILTFEDNND-----W---------------------- 1012
            ::.:...||.|.:   ....|.|:||:|..|.:..::     |
Mouse   877 MEEDVQRTRLLIQ---QVRGFLTDPDTDAATIQQVSEAVLALWLPTDSATVLRKMKEIQAIAARL 938

  Fly  1013 --VTSLQQQEYGDAMAASQVPLAFEDASPGTPRSSDNNEDD------ENAFVFDESLFDASDGTE 1069
              |.|:..|...|...|.::....|.|. ....:.:...||      :......|:. |...||.
Mouse   939 PNVDSVLSQTKQDIARARRLQAEAEQAR-SRAHAVEGQVDDVVGNLRQGTVALQEAQ-DTMQGTG 1001

  Fly  1070 EYQR----------------KQLAQDMKRIMSNSNAHSSHKKAEV-----------QFPPQGSQE 1107
            ...|                ::|.:.||..||...|.....:.:.           |.....||:
Mouse  1002 RSLRLIQERVGEVQQVLVPAERLVKGMKEQMSGFWARMKELRRQAQEEQAQAMQARQLAEGASQQ 1066

  Fly  1108 VGTANEDTSQYSDDYND--DEL-LTPVM--QGGE--EVKLE 1141
            ...|.|...:....|.:  |.| .:||:  ||..  .:|:|
Mouse  1067 AMNAQEGFKRLKQKYTELKDRLGQSPVLGEQGNRILSIKME 1107

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP2353	NP_611082.2	FXa_inhibition	53..82	CDD:464251	6/28 (21%)
		LamG	404..555	CDD:238058	30/157 (19%)
		EGF	583..612	CDD:394967	11/35 (31%)
		LamG	625..774	CDD:238058	36/182 (20%)
		LamG	1205..1340	CDD:214598
Lamb3	NP_032510.2	Laminin_N	20..248	CDD:470680	53/252 (21%)
		EGF_Lam	249..301	CDD:238012	7/51 (14%)
		Laminin_EGF	313..367	CDD:395007	14/78 (18%)
		Laminin_EGF	376..425	CDD:395007	18/102 (18%)
		Laminin_EGF	428..475	CDD:395007	11/48 (23%)
		Laminin_EGF	478..531	CDD:395007	14/53 (26%)
		EGF_Lam	530..579	CDD:238012	11/70 (16%)
		Domain II	576..781		42/247 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	723..760		6/40 (15%)
		Domain alpha	782..812		6/29 (21%)
		Domain I	813..1168		58/305 (19%)
		SMC_prok_B	<830..1161	CDD:274008	55/288 (19%)
		cc_LAMB_C	1098..1168	CDD:424069	3/10 (30%)