DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SP2353 and Hspg2

DIOPT Version :9

Sequence 1:NP_001286474.1 Gene:SP2353 / 36771 FlyBaseID:FBgn0034070 Length:1361 Species:Drosophila melanogaster
Sequence 2:XP_030109089.1 Gene:Hspg2 / 15530 MGIID:96257 Length:4398 Species:Mus musculus


Alignment Length:1111 Identity:234/1111 - (21%)
Similarity:365/1111 - (32%) Gaps:406/1111 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   320 PNVTSNKVQMHITRETNRLENISAAEPAVVGAAMTTDRSTPTCNLDCGSDGICALEATAASSRCL 384
            |.:|.:||...:..: :||||.....|:|    ...|..|..|                      
Mouse  3615 PAITWSKVDGDLPPD-SRLENNMLMLPSV----RPEDAGTYVC---------------------- 3652

  Fly   385 CPFGKTGNGCQEDIRAH---------VPRFAKR--SWLAFPALHGAYKHVQLRIEFRPESFDGII 438
                 |....|..::|.         :|.|.:.  |:|..|.:..||:..:::|.|||:|.||::
Mouse  3653 -----TATNRQGKVKAFAYLQVPERVIPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGML 3712

  Fly   439 LLSGERDDLTG------DFMALLLNKGFVEFWFDCGSGVGSVRSRETILLNEWNSVIIYRHRWDA 497
            |.:|::...|.      ||::..|..|..||.||.|||:.::|....:.|.::::|.:.|.....
Mouse  3713 LYNGQKRSPTNLANRQPDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGQFHTVTLLRSLTQG 3777

  Fly   498 WLVLNHGTKVQGRSNGLFSRITFREPVFLGGIGNITGLAKRLPLAEGFAGCIR--RFVANE---H 557
            .|::.:...|.|.|.|.|..:...|.::|||..:. |...:..|:.||.||:|  |....|   |
Mouse  3778 SLIVGNLAPVNGTSQGKFQGLDLNEELYLGGYPDY-GAIPKAGLSSGFVGCVRELRIQGEEVVFH 3841

  Fly   558 DYKFTEHPLGDVINGFDIQDCSTDKCVRYPCQHGGKCLPSDQGA-ICLCPIGFVGDLCE------ 615
            |...|.|         .|..|.|  |...|||:||:|..|:..: .|:||.||.|..||      
Mouse  3842 DVNLTTH---------GISHCPT--CQDRPCQNGGQCQDSESSSYTCVCPAGFTGSRCEHSQALH 3895

  Fly   616 -------------------------------IRMD----LQVPAFNGSSFLRYAPLGDSALIWLE 645
                                           :|.:    :..|:.:|:......|...:....|.
Mouse  3896 CHPEACGPDATCVNRPDGRGYTCRCHLGRSGVRCEEGVTVTTPSMSGAGSYLALPALTNMHHELR 3960

  Fly   646 LKVTLKPEQADGLILYSGPEHR--GDFIALYLNDGFVEFAFDLGSGPALVRSEHSLSLGQWHTIK 708
            |.|..||.:.:|::|:||.:..  .||::|.:..|.:||.::||||.|::||...|:||:||.:.
Mouse  3961 LDVEFKPLEPNGILLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSHEPLTLGRWHRVS 4025

  Fly   709 ISRTARLAVLKVDKHQEVLTISSNGFWHLSLDQNLFVGGVNHVDRLPLDLKYKPFFVGCIQRIDI 773
            ..|..:...|:||..:.||..|......|:|...|::|||....:|.........|.||:..:.:
Mouse  4026 AERLNKDGSLRVDGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVQLSPATNMSAHFHGCVGEVSV 4090

  Fly   774 NGHSLGIVAEALGGSNIGNC--PHACVARPCGPLAECVPQME-SYECRC--SIHNERCNKAAEVP 833
            ||..|.:....||...:|.|  ...|..:||...|.|:|..| .::|.|  ....:.|       
Mouse  4091 NGKRLDLTYSFLGSQGVGQCYDSSPCERQPCQNGATCMPAGEYEFQCLCQDGFKGDLC------- 4148

  Fly   834 PEQLPELALHKSKVLETKDNGEAAKKVSGLAHKKHSKKHRNLHKPTPATSTTTSTTSTTTTTTEA 898
                                             :|.:....||:|                    
Mouse  4149 ---------------------------------EHEENPCQLHEP-------------------- 4160

  Fly   899 PSERTEEATAGALSNEEIEDDIIFRLVQQQQQQKELKKQHQQTTTTAPATSTTSSGPSKAKPRLS 963
                       .|:.                                   .|.........|..|
Mouse  4161 -----------CLNG-----------------------------------GTCRGARCLCLPGFS 4179

  Fly   964 GKHHASKHEHHLKPNAAFTRKLSRLPTHYESFQTNPDSDILTFEDNNDWVTSLQQQEYGDAMAAS 1028
            |                                                                
Mouse  4180 G---------------------------------------------------------------- 4180

  Fly  1029 QVPLAFEDASPGTPRSSDNNEDDENAFVFDESLFDASDGTEEYQRKQLAQDMKRIMSNSNAHSSH 1093
                         ||....                                           :.:
Mouse  4181 -------------PRCQQG-------------------------------------------AGY 4189

  Fly  1094 KKAEVQFPPQGSQEVGTANEDTSQYSDDYNDDELLTPVMQGGEEVKLEQHTSSTPQTHTDWSLLK 1158
            ...|..:.|:||    ..|:...||...:.|:..|     |.......:.....|:|        
Mouse  4190 GVVESDWHPEGS----GGNDAPGQYGAYFYDNGFL-----GLPGNSFSRSLPEVPET-------- 4237

  Fly  1159 KFDLSAEHQSQVQGVRKNFGACFAGSDSYFHYNDADTMSQVISYSIDLNLRIKTHSENGVILWTG 1223
                                                           :...::|.:.:|::||.|
Mouse  4238 -----------------------------------------------IEFEVRTSTADGLLLWQG 4255

  Fly  1224 RQGTTEEHDDYLSLGIEQGYLHFRYDLGSGEVDIRFNGTKVSDGLWHRVRAIRNSQEGYLEVDGR 1288
            .........|::|||::.|:|.|.|.|||||..: .:...::||.|||:.|:|..|.|.::|||.
Mouse  4256 VVREASRSKDFISLGLQDGHLVFSYQLGSGEARL-VSEDPINDGEWHRITALREGQRGSIQVDGE 4319

  Fly  1289 KTVTLRAPGKLRQLNTDTGLYVGGMPDVGYFTHQRYFSGIVGCISEIVLAGEMKLNFDPNTLGTE 1353
            ..||.|:||....:||...:|:||.|||...|..::.|||.|||..:||.........|..|..:
Mouse  4320 DLVTGRSPGPNVAVNTKDIIYIGGAPDVATLTRGKFSSGITGCIKNLVLHTARPGAPPPQPLDLQ 4384

  Fly  1354 HNVETG 1359
            |..:.|
Mouse  4385 HRAQAG 4390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SP2353NP_001286474.1 FXa_inhibition 53..82 CDD:291342
LamG 404..555 CDD:238058 49/160 (31%)
EGF 583..612 CDD:278437 13/29 (45%)
LamG 625..774 CDD:238058 46/150 (31%)
LamG 1205..1340 CDD:214598 52/134 (39%)
Hspg2XP_030109089.1 EGF_CA 4153..4184 CDD:238011 10/173 (6%)
LamG 4211..4369 CDD:238058 56/218 (26%)
SEA 80..194 CDD:382994
LDLa 216..251 CDD:238060
Ldl_recept_a 300..336 CDD:365841
LDLa 342..376 CDD:238060
LDLa 385..420 CDD:238060
Ig_Perlecan_like 438..515 CDD:143220
LamB 607..733 CDD:214597
EGF_Lam 781..823 CDD:238012
EGF_Lam 830..887 CDD:238012
Laminin_EGF 896..938 CDD:365839
Laminin_B 1007..1141 CDD:365838
EGF_Lam 1175..1224 CDD:238012
EGF_Lam 1225..1281 CDD:238012
Laminin_EGF 1292..1339 CDD:365839
Laminin_B 1413..1545 CDD:365838
EGF_Lam 1580..1628 CDD:238012
EGF_Lam 1629..1686 CDD:238012
IG_like 1699..1779 CDD:214653
Ig_Perlecan_like 1787..1872 CDD:143231
IG_like 1888..1966 CDD:214653
I-set 1972..2058 CDD:369462
IG_like 2073..2150 CDD:214653
IG 2174..2249 CDD:214652
IG 2269..2342 CDD:214652
IG 2364..2441 CDD:214652
Ig 2450..2535 CDD:386229
IG 2563..2632 CDD:214652
IGc2 2658..2717 CDD:197706
IG_like 2748..2825 CDD:214653
IG 2846..2922 CDD:214652
IG_like 2943..3021 CDD:214653
Ig 3034..3120 CDD:386229
IG_like 3132..3213 CDD:214653
IG 3230..3306 CDD:214652
Ig 3327..3390 CDD:319273
Ig 3428..3494 CDD:386229
Ig 3518..3583 CDD:386229
I-set 3587..3669 CDD:369462 16/85 (19%)
LamG 3676..3833 CDD:238058 48/157 (31%)
EGF_CA 3856..3889 CDD:238011 14/32 (44%)
EGF_CA <3901..3930 CDD:238011 1/28 (4%)
LamG 3942..4091 CDD:238058 46/148 (31%)
EGF 4116..4146 CDD:333761 9/29 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 113 1.000 Domainoid score I6118
eggNOG 1 0.900 - - E1_KOG3509
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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