DRSC/TRiP Functional Genomics Resources

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Protein Alignment SP2353 and EGFLAM

DIOPT Version :9

Sequence 1:NP_001286474.1 Gene:SP2353 / 36771 FlyBaseID:FBgn0034070 Length:1361 Species:Drosophila melanogaster
Sequence 2:NP_001192230.1 Gene:EGFLAM / 133584 HGNCID:26810 Length:1017 Species:Homo sapiens


Alignment Length:1140 Identity:277/1140 - (24%)
Similarity:422/1140 - (37%) Gaps:385/1140 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   252 SPTRAPKQRVDVDYGEGDGSDDYSYSYKSDMSVYDDVN--NNQLNLRRNSKSQTYQQTSNTNTAK 314
            ||...|...:.....|..||..|...|.:||...:|..  .:.|:|     ..::::.......|
Human   225 SPRSWPSDIIRTLCPEEAGSGRYGPRYITDMGAGEDDEGFEDDLDL-----DISFEEVKPLPATK 284

  Fly   315 NRRKYPNVTSNKVQMHITRETNRL-ENISAAEPAVV--------------GAAMTTDRSTPTCNL 364
            ...|...|.|.|:.:...:..:|| ...||:.|...              |.|:.:......|:.
Human   285 GGNKKFLVESKKMSISNPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDE 349

  Fly   365 D-CGSDGICALEATAASSRCLCPFGKTGNGCQEDIRAHVPRFAKRSWLAFPALHGAYKHVQLRIE 428
            . |.:|..|..:.|...|||.|..||.|..|.|||....|:|...|::.|..|..:|:..|:.:|
Human   350 TLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLE 414

  Fly   429 FRPESFDGIILLSGERDDLTGDFMALLLNKGFVEFWFDCGSGVGSVRSRETILLNEWNSVIIYRH 493
            ||.|:.||::|..||.:...||||:|.:.:..::|.|:||:||..:.|...|.|..|::|::||.
Human   415 FRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRD 479

  Fly   494 RWDAWLVLNHGTKVQGRSNGLFSRITFREPVFLGGIGNITGLAKRLPLAEGFAGCIRRFVANEHD 558
            ..:..|.||:||.|.|:|.|.:|:||||.|::|||..:...|.:......||.||::....|...
Human   480 GLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRR 544

  Fly   559 YKFTEHPLGDVINGFDIQDCSTDKCVRYPCQHGGKC--LPSDQGAICLCPIGFVGDLCEIRMDLQ 621
            ......|||..::|.|:.:||:..|....|.|||.|  :.:| ..|||||:||.|..||....|.
Human   545 IDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKAD-SYICLCPLGFKGRHCEDAFTLT 608

  Fly   622 VPAFNGSSFLRYA----PL-GDSALIWLELKVTLKPEQADGLILYSGPEHRGDFIALYLNDGFVE 681
            :|.|. .|...||    || ....|.::|.::|.:|:..||::|||......||:::.|..|.||
Human   609 IPQFR-ESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVE 672

  Fly   682 FAFDLGSGPALVRSEHSLSLGQWHTIKISRTARLAVLKVDKHQEVLTISSNGFWHLSLDQNLFVG 746
            |.||.|||..::|||..|:||.||.:::||||:..:|:|||.:.|..::..||..:..:.::|:|
Human   673 FRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIG 737

  Fly   747 GVNHVDRLPLDLK-----YKPFFVGCIQRIDINGHSLGIVAEALGGSNIGNCPHACVARPCGPLA 806
            ||.:.|    |:|     .|| |.|.||:|.:|..::.:..:...|.|:.|..|.||..||....
Human   738 GVPNYD----DVKKNSGVLKP-FSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGG 797

  Fly   807 ECVPQMESYECRCSIHNERCNKAAEVPPEQLPELALHKSKVLETKDNGEAAKKVSGLAHKKHSKK 871
            .|.|:.|.|:|.|                                                    
Human   798 SCRPRKEGYDCDC---------------------------------------------------- 810

  Fly   872 HRNLHKPTPATSTTTSTTSTTTTTTEAPSERTEEATAGALSNEEIEDDIIFRLVQQQQQQKELKK 936
                                                                             
Human   811 ----------------------------------------------------------------- 810

  Fly   937 QHQQTTTTAPATSTTSSGPSKAKPRLSGKHHASKHEHHLKPNAAFTRKLSRLPTHYESFQTNPDS 1001
                                                                             
Human   811 ----------------------------------------------------------------- 810

  Fly  1002 DILTFEDNNDWVTSLQQQEYGDAMAASQVPLAFEDASPGTPRSSDNNEDDENAFVFDESLFDASD 1066
                                         ||.||                               
Human   811 -----------------------------PLGFE------------------------------- 815

  Fly  1067 GTEEYQRKQLAQDMKRIMSNSNAHSSHKKAEVQFPPQGSQEVGTANEDTSQYSDDYNDDELLTPV 1131
                                 ..|.             .:|.|               :..|..:
Human   816 ---------------------GLHC-------------QKECG---------------NYCLNTI 831

  Fly  1132 MQGGEEVKLEQHTSSTPQTHTDWSLLKKFDLSAEHQSQVQGVRKNFGACFAGSDSYFHYNDADTM 1196
            ::..|          .||                               |.|. ||..|::.|.:
Human   832 IEAIE----------IPQ-------------------------------FIGR-SYLTYDNPDIL 854

  Fly  1197 SQVISYSIDLNLRIKTHSENGVILWTGRQGTTEEHDDYLSLGIEQGYLHFRYDLGSGEVDIRFNG 1261
            .:|.....::.:|.||.:::|::||.| ......:.|::|||:..|.|.|.|:||||...|..||
Human   855 KRVSGSRSNVFMRFKTTAKDGLLLWRG-DSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNG 918

  Fly  1262 TKVSDGLWHRVRAIRNSQEGYLEVDGRKTVTLRAPGKLRQLNTDTGLYVGGMPDVGYFTHQRYFS 1326
            : .:||.||||:|:|:.|.|.:.||.....|.::||.:||||.:..||||||.::...|:::|..
Human   919 S-FNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMR 982

  Fly  1327 GIVGCISEIVLAGEMKLNF--------DPNTLGTE 1353
            |:|||||...|:.:..::.        :.||.|.:
Human   983 GLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK 1017

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SP2353NP_001286474.1 FXa_inhibition 53..82 CDD:291342
LamG 404..555 CDD:238058 56/150 (37%)
EGF 583..612 CDD:278437 14/30 (47%)
LamG 625..774 CDD:238058 60/158 (38%)
LamG 1205..1340 CDD:214598 56/134 (42%)
EGFLAMNP_001192230.1 FN3 36..133 CDD:238020
FN3 142..234 CDD:238020 3/8 (38%)
LamG 391..541 CDD:238058 56/149 (38%)
EGF_CA 560..602 CDD:238011 18/42 (43%)
LamG 618..765 CDD:238058 58/151 (38%)
EGF_CA <792..820 CDD:238011 13/303 (4%)
Laminin_G_2 868..993 CDD:280389 54/126 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 113 1.000 Domainoid score I6148
eggNOG 1 0.900 - - E1_KOG3509
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H65044
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D17288at33208
OrthoFinder 1 1.000 - - FOG0007196
OrthoInspector 1 1.000 - - oto88867
orthoMCL 1 0.900 - - OOG6_107971
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4884
SonicParanoid 1 1.000 - - X6075
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.710

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