Protein Alignment SP2353 and SP2353

DIOPT Version :10

• Sequence 1: NP_611082.2
• Gene: SP2353 / 36771
• FlyBaseID: FBgn0034070
• Length: 1361
• Species: Drosophila melanogaster
• Sequence 2: XP_061498284.1
• Gene: SP2353 / 1274724
• VectorBaseID: AGAMI1_008324
• Length: 1705
• Species: Anopheles gambiae
• Alignment Length: 1733
• Identity: 668/1733 - (38%)
• Similarity: 869/1733 - (50%)
• Gaps: 455/1733 - (26%)

  Fly    15 CVWLLLVLSSLSSASI-------AVGAIPEP-------------------EEAAFQGHCGHTSPC 53
            |:...:::||..:.::       .|.|:|.|                   ....|.|.|||.|||
Mosquito    38 CMPFRILISSFPACTLRFDGCTHLVSALPLPPVFPSLPIYFSSLIRNHPVHFIMFSGRCGHGSPC 102

  Fly    54 EQLCYEIHDGMYECDCIEGYELNKNGYSCQVINATSNSLDGRGKSDEDVLYQKGASFSAKL---- 114
            ||||||:|||||||||.||:||||||||||.||:||:. |.....:||||||:||||||||
Mosquito   103 EQLCYELHDGMYECDCSEGFELNKNGYSCQEINSTSSD-DNASNGEEDVLYQRGASFSAKLDISD 166

  Fly   115 -------ANDDGGKSMAKSTFALSAAQ-----------SASPAGNENGEDESGS---------EG 152
                   .:||.|...||:|...|..:           ||:|.......||...         |.
Mosquito   167 LHISMKSFDDDDGAEEAKTTSGGSGGRQGAVTKVPPPSSANPNSINAKSDELARRKANRNWKLEP 231

  Fly   153 DSYDYGELEDSNSETQEQKQKSL--------------------NLQQQQQQQQKVNSNDYYISAE 197
            .|.......:..:.:..:|:||:                    ..||.|||..|.:::    .::
Mosquito   232 SSKQSANANEGRARSSSRKEKSIQNDGLPALVTAYGDGMRHDQRQQQHQQQHPKTSAS----GSD 292

  Fly   198 SINFNSESEGQEQQDVADFKAASTMLPSSVPPTPSRSTTRATASTTTTTTTTRRS----PTRAPK 258
            ...||:.|.|:        |...|    .|..|.:.|:....||....:..:..|    ..|...
Mosquito   293 RRKFNATSAGR--------KGPGT----GVDDTGTGSSNMPLASDMEISGISLHSHLSGEDRGRW 345

  Fly   259 QRVDV-DYGEGDGS--------DDYSYSYKSDMSVYDDVNNNQLNLRRNSKSQTYQQTSNTNTAK 314
            ||..| |......|        ||            ||.::....:|........|:.......:
Mosquito   346 QRAGVPDMAVSSASAALLAVDEDD------------DDDDDGASEIRALPLLAGSQEDEGMQQTQ 398

  Fly   315 NRRKYP-----------------NVTSNKVQMHITRETNRLENISAAEPAVVGAAMTTDRSTPTC 362
            ...|.|                 .|:.:.:.|.....||      |.:....|||:    |.| |
Mosquito   399 REGKLPPEAMGRGVMSPQEPIMQGVSGDGLAMSAEPRTN------ATQQTAEGAAI----SQP-C 452

  Fly   363 NLDCGSDGICALEATAASS--RCLCPFGKTGNGCQEDIRAHVPRFAKRSWLAFPALHGAYKHVQL 425
            .|||||:|.|.:....:||  ||||.|||||..|:||::.:.|||:|.||:|||||.||||||||
Mosquito   453 TLDCGSEGTCYISPEGSSSLMRCLCAFGKTGQRCEEDVKVNTPRFSKHSWVAFPALRGAYKHVQL 517

  Fly   426 RIEFRPESFDGIILLSGERDDLTGDFMALLLNKGFVEFWFDCGSGVGSVRSRETILLNEWNSVII 490
            .|||||||||||:||:|||||||||||||||::||||||||||||:|.|:|.|||:||:||::.|
Mosquito   518 HIEFRPESFDGILLLTGERDDLTGDFMALLLHQGFVEFWFDCGSGMGRVKSEETIVLNQWNTITI 582

  Fly   491 YRHRWDAWLVLNHGTKVQGRSNGLFSRITFREPVFLGGIGNITGLAKRLPLAEGFAGCIRRFVAN 555
            ||||||||||||.|.:|||||.||||||||||||||||.||||||.::||::.||.||||:||||
Mosquito   583 YRHRWDAWLVLNQGNRVQGRSKGLFSRITFREPVFLGGYGNITGLDRKLPVSTGFTGCIRKFVAN 647

  Fly   556 EHDYKFTEHPLGDVINGFDIQDCSTDKCVRYPCQHGGKCLPSDQGAICLCPIGFVGDLCEIRMDL 620
            :|||.|.:..||||.:|||||:|.||:|.||||||||||||||.|||||||:||.|||||:|:||
Mosquito   648 DHDYNFQQGSLGDVSHGFDIQECITDRCSRYPCQHGGKCLPSDDGAICLCPLGFGGDLCEMRLDL 712

  Fly   621 QVPAFNGSSFLRYAPLGDSALIWLELKVTLKPEQADGLILYSGPEHRGDFIALYLNDGFVEFAFD 685
            |||:|||||:|||||||||.:||.|||:.:||...|||:||||....||:|:|.||.|.|||.:|
Mosquito   713 QVPSFNGSSYLRYAPLGDSCIIWFELKIIIKPLLEDGLLLYSGHHEYGDYISLCLNMGHVEFTYD 777

  Fly   686 LGSGPALVRSEHSLSLGQWHTIKISRTARLAVLKVDKHQEVLTISSNGFWHLSLDQNLFVGGVNH 750
            ||||||.||||..||:|||||||:|||:||||||:|:..||:|:|.||||||||..:|::||:::
Mosquito   778 LGSGPATVRSEFPLSMGQWHTIKVSRTSRLAVLKIDQLPEVMTVSPNGFWHLSLPHSLYLGGIHN 842

  Fly   751 VDRLPLDLKYKPFFVGCIQRIDINGHSLGIVAEALGGSNIGNCPHACVARPCGPLAECVPQMESY 815
            |..||..|:.|..|.||||::|||..::.|::|||||||:.|||||||||||||||:|||.:::|
Mosquito   843 VHTLPTSLRDKGSFAGCIQKVDINDRTIAIISEALGGSNVENCPHACVARPCGPLAKCVPNLDTY 907

  Fly   816 ECRCSIHNERCNKAAEVPPEQLPELALHKSKVLETKDNGEAAKKVSGLAHKKHSKKHRNLHKPTP 880
            ||:|:..|.:||||.|:|.|.:.:    :.::|:.|...:|....|.          |:.....|
Mosquito   908 ECQCNPQNRQCNKAEELPSEVIEK----QQRLLKRKQQEQAVAPPSS----------RSTVASEP 958

  Fly   881 ATSTTTSTTSTTTTTTEAPSERT------EEATAGALSNEEIED---DIIFRLVQQQQQQKELKK 936
            ....||...|:.:||...|.|.:      ..|..|..|:||.::   |      ..|....:.:.
Mosquito   959 TQPLTTPLGSSISTTQAPPPEDSTLPHDNNPADVGDGSSEESDEGYND------YYQSDDGDDEG 1017

  Fly   937 QHQQTTTTAPATSTTSSGPSKAKPRLS---GKHHASKHEHHLKPNAAFT-RKLSRLPTH------ 991
            ........:..|...|||....:||..   .::.::..|....|.|||| .:..:..:|
Mosquito  1018 DDDDDDDGSFGTQGMSSGNGYNQPRNRRRWNRYQSAAGEIKTAPPAAFTANEADKQQSHANGAAE 1082

  Fly   992 YESFQTNPDSDILTFEDNNDWVT--------SLQQQEYGD------AMAASQVPLA--------- 1033
            ..|...:|.:..:..|....|:.        |.|..:|.|      ||..:.:..|
Mosquito  1083 TSSTVASPAASTVANEKIIVWIDQQKSKDSFSTQSNDYADYGGGEIAMVENGMESAAVDERPQHG 1147

  Fly  1034 -------------------FEDASPGTPRSSD--------------------------NNEDDEN 1053
                               ..|||.||...:|                          .:|||::
Mosquito  1148 GLKGAEVREDEFSEGRRSGVYDASTGTMVGNDRKMTMVMKANDAGEGDGAGDMMPVEHGDEDDDD 1212

  Fly  1054 AFVFDESLFDASDGTEEYQRKQLAQDMKRIMSNSN-------AHSSHKKAEVQFPPQ-------- 1103
                |:...|..|.|....|.|:  |:....|..:       |:.:|:....:..|:
Mosquito  1213 ----DDDDGDDDDATRSNHRPQV--DVSEESSPKHGKTVKDPANIAHRLRRPEATPETLPASNKD 1271

  Fly  1104 -GSQEVGTANEDTSQYSDDYNDDE-------------------------------LL-------- 1128
             ||.|..::..|:..:.||.|||.                               ||
Mosquito  1272 TGSDEPSSSFADSEDHHDDDNDDSNSADDVAAYDGDGYGKDYDQHGDRIPYRPDFLLHRKQGSSW 1336

  Fly  1129 --------TPVMQG-----------------------------------------------GE-- 1136
                    .|..||                                               ||
Mosquito  1337 RSRGNRPNRPGQQGKQTEPEIDETLIEEMNRIMKNHNDNDNDADETLDASFWGVGPSSDGYGEPS 1401

  Fly  1137 ----EVKL----------------EQHTSSTPQTHTDWSLLKKFDLSAEHQSQVQGVRKNF---- 1177
                |.:|                :.|....|..|...:.:::.|...:|:|:..|:|..:
Mosquito  1402 LTQREYELTETDAEETHDEGAHHHQHHDHRAPSHHRRRNGVEQEDDGDQHESKDTGLRNRYAARG 1466

  Fly  1178 --------------------------------------------------------GACFAGSDS 1186
                                                                    ||||.|:||
Mosquito  1467 QQPHQQDSQSDHRQRQQQQQQQHQQQPQKPQADPRNDEDDILRSIKYKNKYFRKYQGACFTGTDS 1531

  Fly  1187 YFHYNDADTMSQVISYSIDLNLRIKTHSENGVILWTGRQGTTEEHDDYLSLGIEQGYLHFRYDLG 1251
            ||||:||:||.:||||.||||||.||||.||:||||||.... |.||:||||||.||||.||:||
Mosquito  1532 YFHYSDAETMRRVISYEIDLNLRFKTHSANGLILWTGRHSAL-EGDDFLSLGIENGYLHLRYNLG 1595

  Fly  1252 SGEVDIRFNGTKVSDGLWHRVRAIRNSQEGYLEVDGRKTVTLRAPGKLRQLNTDTGLYVGGMPDV 1316
            |||::|::|.|||||||||||||:||||:|.|:|||.|.:|.|:|||||||||||||||||:|..
Mosquito  1596 SGEINIKYNSTKVSDGLWHRVRALRNSQDGTLKVDGGKPITRRSPGKLRQLNTDTGLYVGGLPAA 1660

  Fly  1317 GYFTHQRYFSGIVGCISEIVLAGEMKLNFDPNTLGTEHNVETG 1359
            .::|.|||.:|:||||||::||||::||||...|||.||||.|
Mosquito  1661 AHYTRQRYRTGMVGCISELILAGELRLNFDATILGTAHNVEPG 1703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP2353	NP_611082.2	FXa_inhibition	53..82	CDD:464251	25/28 (89%)
		LamG	404..555	CDD:238058	119/150 (79%)
		EGF	583..612	CDD:394967	24/28 (86%)
		LamG	625..774	CDD:238058	94/148 (64%)
		LamG	1205..1340	CDD:214598	95/134 (71%)
SP2353	XP_061498284.1	None