DRSC/TRiP Functional Genomics Resources

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Protein Alignment SP2353 and Agrn

DIOPT Version :9

Sequence 1:NP_001286474.1 Gene:SP2353 / 36771 FlyBaseID:FBgn0034070 Length:1361 Species:Drosophila melanogaster
Sequence 2:XP_006538554.1 Gene:Agrn / 11603 MGIID:87961 Length:2057 Species:Mus musculus


Alignment Length:1412 Identity:281/1412 - (19%)
Similarity:436/1412 - (30%) Gaps:543/1412 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 EEAAFQGHCG-----------HTSPCEQL-CYEIHDGMYECDCIEGY--ELNKNGYSCQVINATS 89
            |||:..|..|           |..|.|:. ||....|   | |.:|.  .|:..|.:|....|..
Mouse  1066 EEASGGGSGGLEPPVGSVVVTHGPPIERASCYNSPLG---C-CSDGKTPSLDSEGSNCPATKAFQ 1126

  Fly    90 NSLDGRGKSDEDVLYQKGASFSAKLANDDGGKSMAKSTFALSAAQSASPAGNENGEDESGSEGDS 154
            ..|:..|...:::.|                           ..:.|.|.....||.....|   
Mouse  1127 GVLELEGVEGQELFY---------------------------TPEMADPKSELFGETARSIE--- 1161

  Fly   155 YDYGELED--SNSETQEQKQKSLNLQQQQQQQQKVNSNDYYISAESINFNSESEGQEQQDVAD-- 215
               ..|:|  .||:.::                     |::    ||.......|:..:.:.|  
Mouse  1162 ---STLDDLFRNSDVKK---------------------DFW----SIRLRELGPGKLVRAIVDVH 1198

  Fly   216 ------FKAASTMLPSSVPPTPSRSTTRATASTTTTTTTTRRSPTRAPKQRVDVDY------GEG 268
                  |:|          |...::..:....:.......|| |.|...:.:|.|:      |..
Mouse  1199 FDPTTAFQA----------PDVGQALLQQIQVSRPWALAVRR-PLREHVRFLDFDWFPTFFTGAA 1252

  Fly   269 DGSDDYSYSYKSDMSVYDDVNNNQLNLRRNSKSQTYQQTSNTNTAKNRRKYPNVTSNKVQMHITR 333
            .|         :..:|            ..:::.|..:.|.::...  |.||:.||..|......
Mouse  1253 TG---------TTAAV------------ATARATTVSRLSASSVTP--RVYPSYTSRPVGRTTAP 1294

  Fly   334 ETNRLENISAAEPAVVGAAMTTDRSTP-------TCNLD-CGSDGICALEATAASSRCLCPFGKT 390
            .|.|       .|....|::...| ||       :|:.. |...|.|....:.....|.|..|:.
Mouse  1295 LTTR-------RPPTTTASIDRPR-TPGPQRPPKSCDSQPCLHGGTCQDLDSGKGFSCSCTAGRA 1351

  Fly   391 GNGCQEDIRAHVPRFAKRSWLAFPALHGAYKHVQLRIEFRPESFDGIILLSGERDDLTG-DFMAL 454
            |..|::.....||.|...|:||||.|. ||..::|.:|||....:|::|.:|   :..| ||:||
Mouse  1352 GTVCEKVQLPSVPAFKGHSFLAFPTLR-AYHTLRLALEFRALETEGLLLYNG---NARGKDFLAL 1412

  Fly   455 LLNKGFVEFWFDCGSGVGSVRSRETILLNEWNSVIIYRHRWDAWLVLNHGTKVQGRSNGLFSRIT 519
            .|..|.|:|.||.|||...:.|...:....|:.:.:.||.....|.::....|.|.|......:.
Mouse  1413 ALLDGHVQFRFDTGSGPAVLTSLVPVEPGRWHRLELSRHWRQGTLSVDGEAPVVGESPSGTDGLN 1477

  Fly   520 FREPVFLGGI--GNITGLAKRLPLAEGFAGCIRRFVANEHDYKFTEHPLGDVINGFDIQDCSTDK 582
            ....:::||:  ..:..:..|..:..|..||||....|....:.::.... |:....:.:|....
Mouse  1478 LDTKLYVGGLPEEQVATVLDRTSVGIGLKGCIRMLDINNQQLELSDWQRA-VVQSSGVGECGDHP 1541

  Fly   583 CVRYPCQHGG-------------KCLP----------------------------SDQGAICLCP 606
            |...|| |||             :|.|                            |..||.|.||
Mouse  1542 CSPNPC-HGGALCQALEAGVFLCQCPPGRFGPTCADEKNPCQPNPCHGSAPCHVLSRGGAKCACP 1605

  Fly   607 IGFVGDLCEIRMDLQ-----VPAFNGSSFLRY-------APLGDSALIWLELKVTLKPEQADGLI 659
            :|..|..||..::..     :..|||.|:|..       ..||:.    :.|::........||:
Mouse  1606 LGRSGSFCETVLENAGSRPFLADFNGFSYLELKGLHTFERDLGEK----MALEMVFLARGPSGLL 1666

  Fly   660 LYSG--PEHRGDFIALYLNDGFVEFAFDLGSGPALVRSEHSLSLGQWHTIKISRTARLAVLKVDK 722
            ||:|  .:.:|||::|.|::..:||.:|||.|.|::||:..::||.|..:.:.|..|...|:|..
Mouse  1667 LYNGQKTDGKGDFVSLALHNRHLEFRYDLGKGAAIIRSKEPIALGTWVRVFLERNGRKGALQVGD 1731

  Fly   723 HQEVLTIS--SNGFWH--LSLDQNLFVGGVNHVDRLPLDLKYKPFFVGCIQRIDINGHSLGIVAE 783
            ...||..|  |....|  |:|.:.|:|||.....:|.........|.|.||.:.:.||.|.....
Mouse  1732 GPRVLGESPKSRKVPHTMLNLKEPLYVGGAPDFSKLARGAAVASGFDGAIQLVSLRGHQLLTQEH 1796

  Fly   784 ALGGSNIGN-CPHAC---VARPCGPLAECVPQMESYECRCSIHNERCNKAAEVPPEQLPELALHK 844
            .|...::.. ..|.|   |..||.....|:|:..:|||.|                         
Mouse  1797 VLRAVDVAPFAGHPCTQAVDNPCLNGGSCIPREATYECLC------------------------- 1836

  Fly   845 SKVLETKDNGEAAKKVSGLAHKKHSKKHRNLHKPTPATSTTTSTTSTTTTTTEAPSERTEEATAG 909
                                                                           .|
Mouse  1837 ---------------------------------------------------------------PG 1838

  Fly   910 ALSNEEIEDDIIFRLVQQQQQQKELKKQHQQTTTTAPATSTTSSGPSKAKPRLSGKHHASKHEHH 974
            ..|....|..|:.:.|                                                 
Mouse  1839 GFSGLHCEKGIVEKSV------------------------------------------------- 1854

  Fly   975 LKPNAAFTRKLSRLPTHYESFQTNPDSDILTFEDNNDWVTSLQQQEYGDAMAASQVPLAFEDASP 1039
                                    .|.:.|.| |...::      ||.:|:..|:  |..|..:|
Mouse  1855 ------------------------GDLETLAF-DGRTYI------EYLNAVTESE--LTNEIPAP 1886

  Fly  1040 GTPRSSDNNEDDENAFVFDESLFDASDGTEEYQRKQLAQDMKRIMSNSNAHSSHKKAEVQFPPQG 1104
            .|                                    .|.:.:.|.....|:|           
Mouse  1887 ET------------------------------------LDSRALFSEKALQSNH----------- 1904

  Fly  1105 SQEVGTANEDTSQYSDDYNDDELLTPVMQGGEEVKLEQHTSSTPQTHTDWSLLKKFDLSAEHQSQ 1169
                                                                   |:||      
Mouse  1905 -------------------------------------------------------FELS------ 1908

  Fly  1170 VQGVRKNFGACFAGSDSYFHYNDADTMSQVISYSIDLNLRIKTHSENGVILWTGRQGTTEEHDDY 1234
                                                    ::|.:..|::||.|:.|   |..||
Mouse  1909 ----------------------------------------LRTEATQGLVLWIGKVG---ERADY 1930

  Fly  1235 LSLGIEQGYLHFRYDLGSGEVDIRFNGTKVSDGLWHRVRAIRNSQEGYLEVDGRKTVTLRAPGKL 1299
            ::|.|..|:|...|||||..|.:| :..||:...|.||||.|..:||.|:|.....||..:|...
Mouse  1931 MALAIVDGHLQLSYDLGSQPVVLR-STVKVNTNRWLRVRAHREHREGSLQVGNEAPVTGSSPLGA 1994

  Fly  1300 RQLNTDTGLYVGGMP--DVGYFTHQRYFSGIVGCISEIVLAGEMKLN 1344
            .||:||..|::||:.  .||....:.|.:|.|||:.::|: |..:|:
Mouse  1995 TQLDTDGALWLGGLQKLPVGQALPKAYGTGFVGCLRDVVV-GHRQLH 2040

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SP2353NP_001286474.1 FXa_inhibition 53..82 CDD:291342 9/31 (29%)
LamG 404..555 CDD:238058 46/153 (30%)
EGF 583..612 CDD:278437 15/69 (22%)
LamG 625..774 CDD:238058 50/161 (31%)
LamG 1205..1340 CDD:214598 50/136 (37%)
AgrnXP_006538554.1 NtA 46..148 CDD:367356
KAZAL 198..244 CDD:197624
KAZAL 274..319 CDD:197624
Kazal_1 351..391 CDD:333798
KAZAL_FS 423..463 CDD:238052
KAZAL 491..536 CDD:197624
KAZAL 556..601 CDD:197624
KAZAL 621..666 CDD:197624
KAZAL 706..752 CDD:197624
EGF_Lam 795..835 CDD:238012
Laminin_EGF 849..>885 CDD:365839
KAZAL 924..971 CDD:197624
SEA 1121..1245 CDD:214554 27/192 (14%)
EGF 1322..1352 CDD:333761 7/29 (24%)
Laminin_G_1 1389..1520 CDD:333802 36/133 (27%)
Laminin_G_1 1657..1792 CDD:333802 44/134 (33%)
EGF_CA 1814..1846 CDD:238011 11/119 (9%)
Laminin_G_1 1910..2040 CDD:333802 51/134 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3509
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D17288at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10574
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.920

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