Protein Alignment SP2353 and lamb3

DIOPT Version :10

• Sequence 1: NP_611082.2
• Gene: SP2353 / 36771
• FlyBaseID: FBgn0034070
• Length: 1361
• Species: Drosophila melanogaster
• Sequence 2: XP_012826649.2
• Gene: lamb3 / 100125073
• XenbaseID: XB-GENE-983491
• Length: 1157
• Species: Xenopus tropicalis
• Alignment Length: 969
• Identity: 169/969 - (17%)
• Similarity: 266/969 - (27%)
• Gaps: 384/969 - (39%)

  Fly   501 LNHGTKVQGRSNGLFSRITFREPVFLGGIGNITGLAKRLPLAEGFAGCIRRFVANEHDYKFTEHP 565
            |:|..:||..::....|:.|.:.|             |||        .||:......|..
 Frog   198 LSHSQRVQHLADFTNLRLNFTQLV-------------RLP--------PRRYREPSTFYSV---- 237

  Fly   566 LGDV--INGFDIQDCSTDKCVRYPCQHGGKCLPSDQGAI-------------CLCPIGFVGDLCE 615
              ||  ::|         .|..|  .|..:|:||  ||:             |:|....||:.||
 Frog   238 --DVMRVHG---------SCFCY--GHADRCMPS--GALDRDHYGDIQVYDKCICQHNTVGENCE 287

  Fly   616 IRMDLQVPAFNGSSFLRYAPLGDSALIWLELKVTLKPEQADGLILYSGPEHRGDFIALYLNDGFV 680
            ...||    |:.   |.:.|..|:                     |.....|.:     .|:...
 Frog   288 RCADL----FHD---LPWRPADDN---------------------YPNECRRCN-----CNNHAD 319

  Fly   681 EFAFDLGSGPALVRSEHSLSLGQWHTIKISRTARLAVLKVDKHQEVLTISSNGFWHLSLDQNLFV 745
            :..||    ||:..:...:|.|.....:...|.|
 Frog   320 KCHFD----PAVYEASGRVSGGVCDNCRDGTTGR------------------------------- 349

  Fly   746 GGVNHVDRLPLDLKYKP----------FFVGCIQRIDINGHSLGIVA------EALGGSNIGNC- 793
                :.:|...|....|          ....|.....|:|.|...:.      |.:||.....|
 Frog   350 ----NCERCRSDYYRNPNKDMSHRDACISCDCDPEGSIDGGSCDDLTGRCNCKENVGGERCDQCK 410

  Fly   794 ----------PHACVARPCGP--------------LAECVPQMESYEC----------------- 817
                      |..|....|.|              ..:|:|.:....|
 Frog   411 PGYYLLSASNPQGCTKCTCNPQGMERDQPCDSETGQCKCLPNVLGQRCDQCATNHWNLASGRGCE 475

  Fly   818 RCSIH-----NERCNKA---------------AEVPPEQLPELA-------LHKSKVLE---TKD 852
            ||..|     :.:||:|               .|.|......|.       ......||   .|.
 Frog   476 RCGCHPRNSYSLQCNQATGQCLCREGFGGRFCTECPDRMYGSLQTGCRACNCDFQGTLEQGCDKA 540

  Fly   853 NGEAAKK--VSGL---------------AHKKHSKKHRNLHKPTPATSTTTSTTSTTT------- 893
            ||....:  ::|:               ....|...|...|:.....|.|.|..:.||
 Frog   541 NGRCLCRPGITGVRCDSCQRGYSDPFPTCRACHQCFHFYDHEINALRSHTQSLLNMTTGQGQDSD 605

  Fly   894 -------TTTEAPSERTEEATAGALSNEEIEDDIIFRLVQQQQQQKELKKQHQQTTTTAPATSTT 951
                   ...||..:|.:..:.|.    .|.|:   .|.:.:.:...::...||..|..|.
 Frog   606 LGLGPRMAAVEAALQRVQRISTGT----PIPDN---ELSRAESKLSRMRGDAQQLNTNLPE---- 659

  Fly   952 SSGPSKAKPRLSGKHHA-------------SKHEHH------------LKPNAAFTRKLS----- 986
               |....| ||...|:             ||.|.|            :..|:|:...|.
 Frog   660 ---PESFAP-LSNNIHSLRGQFNRINLLYQSKKEQHSSSISNDASGIFMAVNSAYQSSLESAKSI 720

  Fly   987 --------------RLPTHYESFQTNPDSDILTFED----------------------------- 1008
                          |:....|...|...:|:.|.::
 Frog   721 AAAEGVLSQSKDSRRVALGLEGKSTELLADLETLKEELSYPNLTPTINRICEGVRIDPCTPEECP 785

  Fly  1009 ------NNDWVTSLQQQEYGDAMAASQVPLAFEDASPGTPRSSD-----NNEDDENAFVFDESLF 1062
                  ||:.:..:      .::.....||: .:|...|.::|.     ||:..:||.:..
 Frog   786 GPVCQRNNNSLCKV------GSLCRGAFPLS-SNALRNTEKTSQDLQDINNKLQKNALMIQ---- 839

  Fly  1063 DASDGTEEYQ--RKQLAQDMKRIMSNSNAHSSHKKAEVQ----FPPQGSQEVGTANEDTSQYSDD 1121
            ||.....:.|  .|||.:.:.|..|.......|.:..:|    |..:.|.:..|..| .|:|...
 Frog   840 DAEKTASQIQDNAKQLTEQVSRARSRMEEDMGHSRQFIQQVRDFLTEPSTDPATIQE-VSEYILS 903

  Fly  1122 YNDDELLTPVMQGGEEV-----KLEQHTSSTPQTHTDWSLLKKFDLSAE--------HQSQVQGV 1173
            .......:.:::...|:     ||....|...||..|.:..||....||        .:..|.||
 Frog   904 LKLPTDASSILRKMNEIRSIAGKLPNIDSVLSQTKDDIAKAKKLQSEAELARNKAKDVEDGVDGV 968

  Fly  1174 RKNFGACFAGSDSYFHYNDADTMSQVISYSIDLNLRIKTHSENGVILWTGRQGTTEEHD 1232
            ..|.      |.:.....:|:...:..|.|:. .::.:.| |...:|....:|.|:.||
 Frog   969 IMNL------SQAKTALQEAEDKIRGSSSSLQ-QIQNRMH-EIEEVLSPAERGLTDMHD 1019

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SP2353	NP_611082.2	FXa_inhibition	53..82	CDD:464251
		LamG	404..555	CDD:238058	12/53 (23%)
		EGF	583..612	CDD:394967	11/41 (27%)
		LamG	625..774	CDD:238058	19/158 (12%)
		LamG	1205..1340	CDD:214598	7/28 (25%)
lamb3	XP_012826649.2	Laminin_N	25..244	CDD:459653	15/72 (21%)
		EGF_Lam	245..302	CDD:238012	19/67 (28%)
		EGF_Lam	311..369	CDD:238012	13/101 (13%)
		Laminin_EGF	375..424	CDD:395007	9/48 (19%)
		Laminin_EGF	427..474	CDD:395007	5/46 (11%)
		Laminin_EGF	477..525	CDD:395007	8/47 (17%)
		EGF_Lam	525..569	CDD:214543	6/43 (14%)
		SMC_N	<844..1148	CDD:481474	40/185 (22%)
		cc_LAMB3_C	1087..1157	CDD:411974