DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment casp and faf1

DIOPT Version :9

Sequence 1:	NP_611080.1	Gene:	casp / 36769	FlyBaseID:	FBgn0034068	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	XP_002931465.1	Gene:	faf1 / 779467	XenbaseID:	XB-GENE-940895	Length:	655	Species:	Xenopus tropicalis

Alignment Length:	712	Identity:	253/712 - (35%)
Similarity:	397/712 - (55%)	Gaps:	75/712 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSENKDE--ALTSFQSITGIDDVGEAFSHLEAADWNLVEALSRVIPHEDAPLTS-------PHPI 56
            |:.|.|.  .|..||:.|||:::.||.:.||..:|:||.|::.|||.|:..|.|       |:|:
Frog     1 MASNTDREMILADFQACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSEYSGDALPNPV 65

  Fly    57 LVPEPPARNAVESTNGFRPPGFDEMPGTSNASGFFAAALQNQNQNLNLNQPHIQQRFPTSQLLAQ 121
            ............||:          |.:|:.|.|               :|.:    |:.|::.:
Frog    66 FSTAAQTATTAASTS----------PPSSSTSAF---------------RPVV----PSRQIVER 101

  Fly   122 LTSSINLDPASSQNNNQNVITFNIHFNQQLYQLRLPSEATVEQLKRKIFAETSVPVCRQAIRGWP 186
            |:..:|               ||:.:..:...:.|....||..:|:.:..|..:|..:..::||
Frog   102 LSRMLN---------------FNVEYRDKTADVVLEDSCTVGDIKQILENELQIPASKMLLKGW- 150

  Fly   187 PSKASDAQQLGTRLCNLDLSPENEL-ILVDLTEDGFMDTEQDEVTQRVDKDFTIFIQF-ESDPPL 249
              |:.|.:. .|.|.||.|...|.| :|....:...:.::...:.:.::|::.:.|.. |.....
Frog   151 --KSGDVED-STVLRNLHLPKNNNLYVLTPELQLPSLSSQSSALQESLNKNYMLIITHREVQREY 212

  Fly   250 TLSLPGRMTVQEVKMNVFDIKSIPVRHQEWTGWPNGCDNDT-TLAQSGIGL-SHRFAVRSTERSA 312
            :|:..|..|:||||.||:|:.|||||||.|.|||....:|: .||.|||.. .||..|  :.|::
Frog   213 SLNFSGSCTIQEVKRNVYDLTSIPVRHQLWEGWPQSAQDDSMILASSGIDFPCHRLTV--SRRTS 275

  Fly   313 PTNSNQHNAFDVVTVD--SESSTDEFEDATDF--NNAEYIFTDSPPAQPPNRHLIPNDTDDEISG 373
            |..:.:|:......:.  |:|..|:|||||:|  ::.| ||:.|..:......::|.:.::|...
Frog   276 PVQTREHSEEQCTDIHMISDSDGDDFEDATEFGVDDGE-IFSMSSSSALRKSPMMPENAENEADA 339

  Fly   374 STQFVENYKARYGEPCPEFFVGSLENAKQLACLRSAKERKLLAIYLHHGKSILSNVFCDQLMKHE 438
            ..||...:.:|||:..|.||:||||.:.|.|....|::||||||||||.:|:|:||||.|::..|
Frog   340 LLQFTGEFSSRYGDCHPVFFIGSLEGSFQEAFYGKARDRKLLAIYLHHDESVLTNVFCSQMLCAE 404

  Fly   439 SIIQTFKEKFVLYGWDMTYESNKDMFLSSLTACISSNASLTARNIKLDKLPAIMLVGKSRQLGSN 503
            ||:....:.|:.:.||||.|:|:..||:..|....|..:.|.|..|.|:.|..:::...|   |:
Frog   405 SIVSYLSQNFITWAWDMTKEANRARFLTLCTRHFGSVVAQTVRTQKTDQFPLFLIIMGKR---SS 466

  Fly   504 CEVLSVIHGNIGLDDLLTRLIETCEMFEEQLQVEIRQEDERAARDQVKAEQDMAYQETLQADMAK 568
            .|||:||.||..:|:|:.|||...|:|..|.|.:|:.||||.||:.||.|||.||:.:|:|
Frog   467 NEVLNVIQGNTSVDELMMRLISAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEA---- 527

  Fly   569 DAAKRQKEAAQLAERKRMESERAEEDARRESIRLVAQQSLPQEPSEQETGTSKIRVRKPTGDFLE 633
            |.|||:.:..::||:.|:|..|.|::..||:|||..:||||.||.|:....||:|:|.|:|:|||
Frog   528 DRAKREAQEREIAEQFRLEQIRKEQEEEREAIRLSLEQSLPPEPLEESEPLSKLRIRTPSGEFLE 592

  Fly   634 RRFFINNNLQDLLNFVTANGFLIEEYKLISSWPRRDLTAIESSQTLESLKLYPQETVILEER 695
            |||..::.||.:|:||.:.|:..:|:||||::||||:|.::.:::|..||||||||:.||.:
Frog   593 RRFLGSSPLQVVLDFVASKGYPCQEFKLISTFPRRDVTQLDPNRSLLDLKLYPQETLFLEAK 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
casp	NP_611080.1	UBA_FAF1	12..44	CDD:270596	14/31 (45%)
		UBL	148..>182	CDD:176364	6/33 (18%)
		UAS_FAF1	392..530	CDD:239288	60/137 (44%)
		Faf1_UBX	616..695	CDD:176366	39/78 (50%)
faf1	XP_002931465.1	UBA_FAF1	14..46	CDD:270596	14/31 (45%)
		Ubl1_FAF1	105..177	CDD:340649	21/90 (23%)
		Ubl2_FAF1	198..273	CDD:340650	32/76 (42%)
		UAS_FAF1	358..493	CDD:239288	60/137 (44%)
		DUF5401	<467..>565	CDD:375164	47/101 (47%)
		UBX_UBXN3A	580..654	CDD:340469	38/73 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	299	1.000	Domainoid score	I1429
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5120
Inparanoid	1	1.050	400	1.000	Inparanoid score	I1883
OMA	1	1.010	-	-		QHG49530
OrthoDB	1	1.010	-	-		D363568at33208
OrthoFinder	1	1.000	-	-		FOG0006030
OrthoInspector	1	1.000	-	-		oto102585
Panther	1	1.100	-	-	LDO	PTHR23322
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2328
SonicParanoid	1	1.000	-	-		X5739
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110