DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment casp and Faf2

DIOPT Version :9

Sequence 1:	NP_611080.1	Gene:	casp / 36769	FlyBaseID:	FBgn0034068	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	NP_848484.2	Gene:	Faf2 / 76577	MGIID:	1923827	Length:	445	Species:	Mus musculus

Alignment Length:	354	Identity:	83/354 - (23%)
Similarity:	160/354 - (45%)	Gaps:	49/354 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   356 QPPNRHLIPNDTDDEISGSTQFVENYKARYGEPCPEFFVGSLENAKQLACLRSAK-ERKLLAIYL 419
            :|..|..:.:...|.:|    |:.:::.:||...|.|:.|:...|     |..|| |.:.|.:||
Mouse   122 RPDPRSRVTDPVGDIVS----FMHSFEEKYGRAHPVFYQGTYSQA-----LNDAKRELRFLLVYL 177

  Fly   420 HHGKSILSNVFCDQLMKHESIIQTFKEKFVLYGWDMTYESNKDMFLSSLTACISSN------ASL 478
            |......|:.||...:....:|.....:.:.:                  || |:|      .|.
Mouse   178 HGDDHQDSDEFCRNALCAPEVISLINSRMLFW------------------AC-STNKPEGYRVSQ 223

  Fly   479 TARNIKLDKLPAIMLVGKSRQLGSNCEVLSVIHGNIGLDDLLTRLIETCEMFEEQLQVEIRQEDE 543
            ..|......|..|||  |.|::    .|:..:.|.|..|||:.:|....:..:..|..|..:.:|
Mouse   224 ALRENTYPFLAMIML--KDRRM----TVVGRLEGLIQPDDLINQLTFIMDANQTYLVSERLEREE 282

  Fly   544 RAARDQVKAEQDMAYQETLQADMAKDAAKRQKEAAQLAERKRMESERAEEDARRESIRLVAQ--- 605
            |.....::.:||.||..:|:||..|:..||:::..:..:.:.::.::..|:.||::::...:
Mouse   283 RNQTQVLRQQQDEAYLASLRADQEKERKKREEKERKRRKEEEVQQQKLAEERRRQNLQEEKERKL 347

  Fly   606 QSLPQEPSEQETGTSKIRVRKPTGDFLERRFFINNNLQDLLNFVTANGFLIEEYKLISSWPRRDL 670
            :.||.|||..:..:.||..:.|....:||||..:.:|..:.:|:.:.....|::::.:::|||.|
Mouse   348 ECLPPEPSPDDPESVKIIFKLPNDSRVERRFHFSQSLTVIHDFLFSLKESPEKFQIEANFPRRVL 412

  Fly   671 TAIESSQ-----TLESLKLYPQETVILEE 694
            ..:.|.:     ||:...|...|.:.:::
Mouse   413 PCVPSEEWPNPPTLQEAGLSHTEVLFVQD 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
casp	NP_611080.1	UBA_FAF1	12..44	CDD:270596
		UBL	148..>182	CDD:176364
		UAS_FAF1	392..530	CDD:239288	34/144 (24%)
		Faf1_UBX	616..695	CDD:176366	19/84 (23%)
Faf2	NP_848484.2	UBA_FAF2	15..52	CDD:270597
		UAS_ETEA	154..269	CDD:239289	34/144 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..361		14/60 (23%)
		UBX_UBXN3B	362..441	CDD:340537	19/78 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1363
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2328
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840