DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment casp and faf2

DIOPT Version :9

Sequence 1:	NP_611080.1	Gene:	casp / 36769	FlyBaseID:	FBgn0034068	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	NP_001039235.1	Gene:	faf2 / 734096	XenbaseID:	XB-GENE-948050	Length:	445	Species:	Xenopus tropicalis

Alignment Length:	365	Identity:	88/365 - (24%)
Similarity:	153/365 - (41%)	Gaps:	71/365 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   356 QPPNRHLIPNDTDDEISGSTQFVENYKARYGEPCPEFFVGSLENAKQLACLRSAK-ERKLLAIYL 419
            :|..|..:.:...|.:|    |::.::.:||...|.|:.|:...|     |..|| |.:.|.:||
Frog   122 RPDPRSRVTDPVGDVVS----FIQLFEEKYGRIHPVFYQGTYSQA-----LNDAKQELRFLLVYL 177

  Fly   420 HHGKSILSNVFCDQLMKHESIIQTFKEKFVLYGWDMTYESNKDMFLSSLTACISSN------ASL 478
            |......|:.||...:....:......:.:.:                  || |:|      .|.
Frog   178 HGEDHQDSDDFCRNTLCIPEVTNFLNSRMLFW------------------AC-STNKPEGFRVSQ 223

  Fly   479 TARNIKLDKLPAIMLVGKSRQLGSNCEVLSVIHGNIGLDDLLTRLIETCEMFEEQLQVEIRQEDE 543
            ..|......|..|||  |.|::    .|:..:.|.|...||:.:|....|..:..|..|..:.:|
Frog   224 ALRENTYPFLAMIML--KDRRM----TVVGRLEGLIQPQDLINQLTFIVEANQTYLVSERLEREE 282

  Fly   544 RAARDQVKAEQDMAYQETLQADMAKDAAKRQKEAAQLAERKRMESERA--------------EED 594
            |.....::.:||.||..:|:||..|:..|::|:     |:||.|.|.|              ||:
Frog   283 RNQTQVLRQQQDEAYLASLRADQEKERKKKEKQ-----EQKRREEEEAQLKQMLEERKKRNLEEE 342

  Fly   595 ARRESIRLVAQQSLPQEPSEQETGTSKIRVRKPTGDFLERRFFINNNLQDLLNFVTANGFLIEEY 659
            ..|:|      :.||.||........||..:.|.|..:||||....:|..:.:|:.:.....|::
Frog   343 KERKS------ECLPAEPVPDHPDNVKIIFKMPNGTRVERRFLFTQSLSVIHDFLFSLKETPEKF 401

  Fly   660 KLISSWPRRDLTAIESSQ-----TLESLKLYPQETVILEE 694
            ::::::|||.|..:.|.:     ||:...|...:.:.:::
Frog   402 QIVTNFPRRVLPCLPSEEIPVPPTLQEAGLSQSQLLFVQD 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
casp	NP_611080.1	UBA_FAF1	12..44	CDD:270596
		UBL	148..>182	CDD:176364
		UAS_FAF1	392..530	CDD:239288	33/144 (23%)
		Faf1_UBX	616..695	CDD:176366	19/84 (23%)
faf2	NP_001039235.1	UBA_FAF2	15..52	CDD:270597
		UAS_ETEA	154..269	CDD:239289	33/144 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	303..354		17/61 (28%)
		UBX_UBXN3B	362..441	CDD:340537	19/78 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2328
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940