DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment casp and faf2

DIOPT Version :9

Sequence 1:	NP_611080.1	Gene:	casp / 36769	FlyBaseID:	FBgn0034068	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	NP_001122152.1	Gene:	faf2 / 497596	ZFINID:	ZDB-GENE-050208-312	Length:	445	Species:	Danio rerio

Alignment Length:	358	Identity:	93/358 - (25%)
Similarity:	157/358 - (43%)	Gaps:	57/358 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   356 QPPNRHLIPNDTDDEISGSTQFVENYKARYGEPCPEFFVGSLENAKQLACLRSAK-ERKLLAIYL 419
            :|..|..:.:...|.:|    |:.:::.:||...|.|:.|:...|     |..|| |.:.|.:||
Zfish   122 RPDPRGRVTDPVGDVMS----FIHSFEEKYGRSHPVFYQGTYSQA-----LNDAKRELRYLLVYL 177

  Fly   420 HHGKSILSNVFCDQLMKHESIIQTFKEKFVLYGWDMTYESNKDMFLSSLTACISS-----NASLT 479
            |......::.||...:..|..: ||....:|: |                ||.:|     ..|..
Zfish   178 HGEDHQDTDEFCRSTLCSEEAL-TFINTRMLF-W----------------ACSTSKPEGYRVSQA 224

  Fly   480 ARNIKLDKLPAIMLVGKSRQLGSNCEVLSVIHGNIGLDDLLTRLIETCEMFEEQLQVEIRQEDER 544
            .|......|..|||  |.|::    .|:..:.|.|..:||:.:|....|..:..|..|..:.:||
Zfish   225 LRENTYPFLAMIML--KDRKM----TVVGRLEGLIQPEDLINQLTFIMEANQTYLMSERLEREER 283

  Fly   545 AARDQVKAEQDMAYQETLQADMAKDAAKRQKEAAQLAERKRMESER------AEEDARR--ESIR 601
            .....::.:||.||:.:|:||..||..||:::     |:||.|.|:      |||..||  |..:
Zfish   284 NQTQVLRQQQDEAYEASLRADQEKDRKKREEQ-----EQKRQEEEKVRQTVLAEERRRRTLEEEK 343

  Fly   602 LVAQQSLPQEPSEQETGTSKIRVRKPTGDFLERRFFINNNLQDLLNFVTANGFLIEEYKLISSWP 666
            ....:.||.||...:....||..|.|....:||||....:|..:.:|:.:.....|::::::::|
Zfish   344 ERRSECLPAEPPVDDPDGVKIVFRLPNDTRVERRFLFGQSLTVIHDFLFSLKETPEKFQVVTNYP 408

  Fly   667 RRDLTAIESSQ-----TLESLKLYPQETVILEE 694
            ||.|..:.:..     ||....|...|.:.:::
Zfish   409 RRVLPCLPTEDEPNPPTLMEAGLSRSEVLFVQD 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
casp	NP_611080.1	UBA_FAF1	12..44	CDD:270596
		UBL	148..>182	CDD:176364
		UAS_FAF1	392..530	CDD:239288	36/143 (25%)
		Faf1_UBX	616..695	CDD:176366	19/84 (23%)
faf2	NP_001122152.1	UBA_FAF2	15..52	CDD:270597
		UAS_ETEA	154..269	CDD:239289	36/143 (25%)
		Faf1_like2_UBX	358..442	CDD:176369	19/84 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1363
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2328
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840