DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment casp and ubc-23

DIOPT Version :9

Sequence 1:	NP_611080.1	Gene:	casp / 36769	FlyBaseID:	FBgn0034068	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	NP_509498.4	Gene:	ubc-23 / 182989	WormBaseID:	WBGene00006718	Length:	395	Species:	Caenorhabditis elegans

Alignment Length:	353	Identity:	87/353 - (24%)
Similarity:	157/353 - (44%)	Gaps:	83/353 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 VDSESSTDEFEDATDFNNAEY---------------------IFTDSPPAQPPNRHLIPNDTDDE 370
            ||::..:.:     ||.|.||                     ::..:||...|: |..|  ..|.
Worm    67 VDNQRGSRD-----DFGNDEYDNNGIGGTANILNDEVGESSTLYQVAPPLMMPH-HSQP--IPDA 123

  Fly   371 ISGSTQFVENYKARY---GEPCPEFFVGSLENAKQLACLRSAKER------KLLAIYLHHGKS-- 424
            :.   .:.:|:..||   ....|:|:..:|.||     ::.|.::      :.||.::::..|
Worm   124 LK---CYTDNFNTRYQIGSTVMPKFYTDTLRNA-----VKEAFDQENPILCRPLAFFINNENSSN 180

  Fly   425 ---ILSNVFCDQLMKHESIIQTFKEKFVLYGWDMTYESNKDMFLSSLTACISSNASLTARNIK-- 484
               .::||.|::|:  .|.:.|   |::||.||:|...|.|.||..||   .||.|....|:|
Worm   181 TRNFVTNVLCNELV--TSYLAT---KYILYPWDVTEPRNLDRFLRILT---DSNMSSMHYNLKSF 237

  Fly   485 ----LDKLPAIMLVGKSRQLGSNCEVLSVIHGNIGLDDLLTRLIETC-EMFEEQLQVEIRQEDER 544
                ..:.|.|.:|.:.   |:..||:..::|...|::::..|.|.. |:.||:|:|..:|.:.:
Worm   238 NESESHRFPYIAIVLRK---GNWFEVIREVNGTSDLNEVVNALYEGFEELQEEKLRVLSKQVERK 299

  Fly   545 AARDQVKAE------QDMAYQETLQADMAKDAAKRQKEAAQLAERKRMESERAEEDARRESIRL- 602
            ..:.:|:.|      |:..|.:.|:.|......||      :|.:..:|:.|.|...:...:::
Worm   300 TKQAKVEEERKLIDQQNEVYYKNLKIDTDNLNKKR------IAAKSEIETTRPETKPKITPMKVI 358

  Fly   603 -VAQQSLPQEPSEQETGTSKIRVRKPTG 629
             |..|:||:||:..||....::.|.|.|
Worm   359 SVTPQNLPEEPNVSETNIVTVKFRLPKG 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
casp	NP_611080.1	UBA_FAF1	12..44	CDD:270596
		UBL	148..>182	CDD:176364
		UAS_FAF1	392..530	CDD:239288	42/155 (27%)
		Faf1_UBX	616..695	CDD:176366	5/14 (36%)
ubc-23	NP_509498.4	UBA_4	13..54	CDD:373127
ubc-23	NP_509498.4	UAS	125..278	CDD:214737	43/171 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166125
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1363
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363568at33208
OrthoFinder	1	1.000	-	-		FOG0006030
OrthoInspector	1	1.000	-	-		otm14391
orthoMCL	1	0.900	-	-		OOG6_107273
Panther	1	1.100	-	-	O	PTHR23322
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2328
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.780