DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment casp and FAF1

DIOPT Version :9

Sequence 1:	NP_611080.1	Gene:	casp / 36769	FlyBaseID:	FBgn0034068	Length:	695	Species:	Drosophila melanogaster
Sequence 2:	NP_008982.1	Gene:	FAF1 / 11124	HGNCID:	3578	Length:	650	Species:	Homo sapiens

Alignment Length:	710	Identity:	244/710 - (34%)
Similarity:	382/710 - (53%)	Gaps:	76/710 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSENKDE--ALTSFQSITGIDDVGEAFSHLEAADWNLVEALSRVIPHEDAPLTSPH-PILVPEPP 62
            |:.|.|.  .|..||:.|||:::.||.:.||..:|:||.|::.|||.|:..|.|.: ...:|.|
Human     1 MASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSEYGGETIPGP- 64

  Fly    63 ARNAVESTNGFRPPGFDEMPGTSNASGFFAAALQNQNQNLNLNQPHIQQRFPTSQLLAQLTSSIN 127
                     .|.|........||::|..|...:                  |:.|::
Human    65 ---------AFNPASHPASAPTSSSSSAFRPVM------------------PSRQIV-------- 94

  Fly   128 LDPASSQNNNQNVITFNIHFNQQLYQLRLPSEATVEQLKRKIFAETSVPVCRQAIRGWPPSKASD 192
                   .....::.|.:.:..:...:.|....||.::|:.:..|..:||.:..::||......|
Human    95 -------ERQPRMLDFRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKMLLKGWKTGDVED 152

  Fly   193 AQQLGTRLCNLDLSPENELILVDLTED---GFMDTEQDEVTQRVDKDFTIFIQF-ESDPPLTLSL 253
            :    |.|.:|.|...|.|.:  ||.|   ....:....:.:.::::|.:.|.. |......|:.
Human   153 S----TVLKSLHLPKNNSLYV--LTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQREYNLNF 211

  Fly   254 PGRMTVQEVKMNVFDIKSIPVRHQEWTGWPNGCDNDT-TLAQSGIGL-SHRFAVRSTERSAPTNS 316
            .|..|:||||.||:|:.|||||||.|.|||....:|: .||:||:.. .||..|  ..||:|..:
Human   212 SGSSTIQEVKRNVYDLTSIPVRHQLWEGWPTSATDDSMCLAESGLSYPCHRLTV--GRRSSPAQT 274

  Fly   317 NQHNAFDVVTVD--SESSTDEFEDATDF---NNAEYIFTDSPPAQPPNRHLIPNDTDDEISGSTQ 376
            .:.:...:..|.  |:|..|:|||||:|   :...:....|...:.|   ::|.:.::|.....|
Human   275 REQSEEQITDVHMVSDSDGDDFEDATEFGVDDGEVFGMASSALRKSP---MMPENAENEGDALLQ 336

  Fly   377 FVENYKARYGEPCPEFFVGSLENAKQLACLRSAKERKLLAIYLHHGKSILSNVFCDQLMKHESII 441
            |...:.:|||:..|.||:||||.|.|.|....|::||||||||||.:|:|:||||.|::..|||:
Human   337 FTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIV 401

  Fly   442 QTFKEKFVLYGWDMTYESNKDMFLSSLTACISSNASLTARNIKLDKLPAIMLVGKSRQLGSNCEV 506
            ....:.|:.:.||:|.:||:..||:.......|..:.|.|..|.|:.|..:::...|   |:.||
Human   402 SYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKR---SSNEV 463

  Fly   507 LSVIHGNIGLDDLLTRLIETCEMFEEQLQVEIRQEDERAARDQVKAEQDMAYQETLQADMAKDAA 571
            |:||.||..:|:|:.||:...|:|..|.|.:|:.||||.||:.||.|||.||:.:|:|    |.|
Human   464 LNVIQGNTTVDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEA----DRA 524

  Fly   572 KRQKEAAQLAERKRMESERAEEDARRESIRLVAQQSLPQEPSEQET-GTSKIRVRKPTGDFLERR 635
            ||:....::||:.|:|..|.|::..||:|||..:|:||.||.|:.. ..||:|:|.|:|:|||||
Human   525 KREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALPPEPKEENAEPVSKLRIRTPSGEFLERR 589

  Fly   636 FFINNNLQDLLNFVTANGFLIEEYKLISSWPRRDLTAIESSQTLESLKLYPQETVILEER 695
            |..:|.||.:.:||.:.||..:||||:|::||||:|.::.:::|..:||:||||:.||.:
Human   590 FLASNKLQIVFDFVASKGFPWDEYKLLSTFPRRDVTQLDPNKSLLEVKLFPQETLFLEAK 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
casp	NP_611080.1	UBA_FAF1	12..44	CDD:270596	14/31 (45%)
		UBL	148..>182	CDD:176364	7/33 (21%)
		UAS_FAF1	392..530	CDD:239288	58/137 (42%)
		Faf1_UBX	616..695	CDD:176366	38/79 (48%)
FAF1	NP_008982.1	UBA_FAF1	14..46	CDD:270596	14/31 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..87		8/34 (24%)
		UAS_FAF1	352..487	CDD:239288	58/137 (42%)
		Stathmin	<471..559	CDD:279209	39/91 (43%)
		Faf1_UBX	570..649	CDD:176366	38/78 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158487
Domainoid	1	1.000	282	1.000	Domainoid score	I1673
eggNOG	1	0.900	-	-		E1_KOG1363
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5120
Inparanoid	1	1.050	382	1.000	Inparanoid score	I2061
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49530
OrthoDB	1	1.010	-	-		D363568at33208
OrthoFinder	1	1.000	-	-		FOG0006030
OrthoInspector	1	1.000	-	-		oto88718
orthoMCL	1	0.900	-	-		OOG6_107273
Panther	1	1.100	-	-	LDO	PTHR23322
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2328
SonicParanoid	1	1.000	-	-		X5739
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800