DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8399 and frrs1b

DIOPT Version :9

Sequence 1:	NP_001286472.1	Gene:	CG8399 / 36768	FlyBaseID:	FBgn0034067	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	XP_017209487.1	Gene:	frrs1b / 557898	ZFINID:	ZDB-GENE-080917-44	Length:	609	Species:	Danio rerio

Alignment Length:	582	Identity:	170/582 - (29%)
Similarity:	264/582 - (45%)	Gaps:	67/582 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MRSWLATLVTALLAVAIWPDPGQSLPQGAPETVCDTMLPFHSGGSVLPQNSVSPFSVETSSSTLG 71
            |:.|:     .||.:.|..:.......|.....|:.|.|.|...   |:.:..||.:....|...
Zfish     1 MKMWI-----VLLLLLIHSETVLCYSDGNVVVACEDMTPQHGYD---PKTTDPPFIITADKSQFS 57

  Fly    72 QGQTLRVDLT-GVPAGLS-FGGYMIQARNRNPPHQIIGQFGPARDGTIKLMNCENSVNNSATHSN 134
            .|..::|.|. |...|.. |.|::|:|||....::|:|.|........:|:.|.|..:::.:|::
Zfish    58 PGDEVKVTLAMGFSEGKKYFKGFLIEARNAGNLNEIVGSFKLISSDLSQLLTCNNKRDSAVSHTS 122

  Fly   135 AGPKQQVILEWQSPVDFLGQVVFNATIAQSYNEFWVGVPSQPVQIVRRDLSAAPPLPTQSPSAPA 199
            ...|.:|.:.|.:|.|....|.|..|:||..:::||.:|.   .:|.::.:|.||..|...|..:
Zfish   123 GKHKTEVQVIWVAPPDSPSSVQFLVTVAQGMHDYWVKIPG---PLVSQNGAAPPPQTTFGGSIQS 184

  Fly   200 GTTRAPYVPPSYVAPNNVVAVSSDPIYNGCGQSKNCFGFPDGCVATK--SCTSITVVTVRGDVFE 262
            .||.:..:..|:.|             :|||..|:|...|:||....  :|..::.......|.
Zfish   185 ETTTSSTLSRSFTA-------------DGCGIEKSCLRDPEGCEPQNDAACHFLSFRAESNSVM- 235

  Fly   263 FEIQSGKGTNAAYVAVGLSDDAKMGDDLTTECVPENGRVNLYSSLTSASPYSAVRS-NVNQNSAR 326
            ||:   .|....||:..||.|..||:|....|:.::.||::.::......:..:.| ||.::.|.
Zfish   236 FEL---SGPAEGYVSFALSLDKWMGNDDVYLCIRDSDRVDIKAAYVVGRTHPQISSQNVLKDRAW 297

  Fly   327 LLDASIVDGVIYCRVQRDAVTNVQGRTFDLR----NGKYHLLVASGSSLKENSVGYHDIGRLPSA 387
            .|.    ||||.|..:||    |.....||.    :..|:|.:|.|.: .:.....||      .
Zfish   298 RLS----DGVIQCSFRRD----VHQPPEDLNRFSLDQMYYLFMAHGRA-DDGRTHRHD------R 347

  Fly   388 QPINLAEVQDLSGS--------SRLLIQLHGAFMIAAWIGTTSLGIIFARYFKQTWVGSQSCGTD 444
            ||:..|...|::||        |.||::.|||.|:.||..|.:.|:|.|||||..|......|..
Zfish   348 QPLISASQTDMTGSPKEIGGSRSPLLMKFHGALMLIAWTSTVTAGVIMARYFKPDWPEQNILGQK 412

  Fly   445 QWFAWHRLLMVTTWSLTVAAYVLIWVELKQAVWH----AHSIIGLITVILCFIQPIGALFRPGPN 505
            .||..||:||..|..||:.|:||.::  .:..|.    .|..:|.:.:.|..|||:.|||||.|:
Zfish   413 VWFQLHRMLMSLTVLLTLVAFVLPFI--YRGGWSKRAGIHPYLGCVVMALTLIQPVMALFRPAPD 475

  Fly   506 DKKRPYFNWGHWLGGNLAHILGIVTIFFSVKLPKAELPE-WMDWILVSFVVVHVLVHLIFSI 566
            ..:|..|||.|:..|..|.|:.:||||..:......||. |...:|...|:..||..|:..:
Zfish   476 AARRYIFNWMHFGTGTAAQIVAVVTIFLGIHQQALFLPSPWATGLLAFTVIWFVLADLVLEV 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8399	NP_001286472.1	Reeler	40..170	CDD:280232	36/131 (27%)
		DOMON_SDR_2_like	223..392	CDD:187686	47/175 (27%)
		Cyt_b561_FRRS1_like	358..553	CDD:176490	72/207 (35%)
frrs1b	XP_017209487.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574265
Domainoid	1	1.000	111	1.000	Domainoid score	I6184
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3642
OMA	1	1.010	-	-		QHG46024
OrthoDB	1	1.010	-	-		D464310at33208
OrthoFinder	1	1.000	-	-		FOG0001198
OrthoInspector	1	1.000	-	-		otm26312
orthoMCL	1	0.900	-	-		OOG6_102865
Panther	1	1.100	-	-	O	PTHR45828
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4013
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910