Protein Alignment CG8399 and FRRS1

DIOPT Version :9

• Sequence 1: NP_001286472.1
• Gene: CG8399 / 36768
• FlyBaseID: FBgn0034067
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: NP_001013682.2
• Gene: FRRS1 / 391059
• HGNCID: 27622
• Length: 626
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 179/597 - (29%)
• Similarity: 274/597 - (45%)
• Gaps: 77/597 - (12%)

  Fly    13 TLVTALLAVAIWPDPGQSLPQGAPETVCDTMLPFHSGGSVLPQNSVSPFSVETSSSTLGQGQTLR 77
            ||.|.:|.:.|  ....:.|.|.....|..|:|.| |.|  || ||....:..|..|...|..:.
Human     7 TLGTCILLLHI--SYVANYPNGKVTQSCHGMIPEH-GHS--PQ-SVPVHDIYVSQMTFRPGDQIE 65

  Fly    78 VDLTGVPAGLSFGGYMIQARN----RNPPHQIIGQFGPARDGTIKLMNCENSVNNSATHSNAGPK 138
            |.|:|.|    |.|::::|||    ..||   ||.|........:|:.||:...::.:|.:|..|
Human    66 VTLSGHP----FKGFLLEARNAEDLNGPP---IGSFTLIDSEVSQLLTCEDIQGSAVSHRSASKK 123

  Fly   139 QQVILEWQSPVDFLGQVVFNATIAQSYNEFWVGVPSQPVQIVRRDLSAAPPLPTQSPSAPAGTTR 203
            .::.:.|.:|........|..|:.:.|..:||.:|.              |:.:|..:.|..|.:
Human   124 TEIKVYWNAPSSAPNHTQFLVTVVEKYKIYWVKIPG--------------PIISQPNAFPFTTPK 174

  Fly   204 APYVPPSYVAPNNVVAVSSDPI-YNGCGQSKNCFGFPDGCVATKSCTSITVVTVRGDVFEFEIQS 267
            |..||...:.|   |:..:.|. .:.||..|.|...|..|...|..:.:.:...|.|  :..:..
Human   175 ATVVPLPTLPP---VSHLTKPFSASDCGNKKFCIRSPLNCDPEKEASCVFLSFTRDD--QSVMVE 234

  Fly   268 GKGTNAAYVAVGLSDDAKMGDDLTTECVPENGRVNLY-SSLTSAS-PYSAVRSNVNQNSARLLDA 330
            ..|.:..|::..||.|..||||....|:.|:..|.:. |.||..| |....|..:...:.||
Human   235 MSGPSKGYLSFALSHDQWMGDDDAYLCIHEDQTVYIQPSHLTGRSHPVMDSRDTLEDMAWRL--- 296

  Fly   331 SIVDGVIYCRVQRD-AVTNVQGRTFDLRNGKYHLLVASGSSLKENSVGYHDIGRL--PSAQPINL 392
              .|||:.|..:|: .:..|:.| ||| |..|::.:|.|::         :.||:  .|.||:..
Human   297 --ADGVMQCSFRRNITLPGVKNR-FDL-NTSYYIFLADGAA---------NDGRIYKHSQQPLIT 348

  Fly   393 AEVQDLSGS--------SRLLIQLHGAFMIAAWIGTTSLGIIFARYFKQTWVGSQSCGTDQWFAW 449
            .|..|::.|        |.||:::|||.|..||:.|.|:|::.||:||..|..:...|...||..
Human   349 YEKYDVTDSPKNIGGSHSVLLLKVHGALMFVAWMTTVSIGVLVARFFKPVWSKAFLLGEAAWFQV 413

  Fly   450 HRLLMVTTWSLTVAAYVLIWVELKQAVW--HA--HSIIGLITVILCFIQPIGALFRPGPNDKKRP 510
            ||:||.||..||..|:|:.::  .:..|  ||  |..:|.|.:.|..:||:.|:|||..:|.:|.
Human   414 HRMLMFTTTVLTCIAFVMPFI--YRGGWSRHAGYHPYLGCIVMTLAVLQPLLAVFRPPLHDPRRQ 476

  Fly   511 YFNWGHWLGGNLAHILGIVTIFFSVKLPKAELPE-WMDWILVSFVVVHVLVHLIFSIGLCLNHWQ 574
            .|||.||..|..|.|:.:..:|..:.||...||: |..:.:..||..||...::    |.|.:|.
Human   477 MFNWTHWSMGTAARIIAVAAMFLGMDLPGLNLPDSWKTYAMTGFVAWHVGTEVV----LELKYWM 537

  Fly   575 IGGMASERHLSQ 586
            :....|..||.|
Human   538 MTEFRSFSHLLQ 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8399	NP_001286472.1	Reeler	40..170	CDD:280232	38/133 (29%)
		DOMON_SDR_2_like	223..392	CDD:187686	49/174 (28%)
		Cyt_b561_FRRS1_like	358..553	CDD:176490	71/209 (34%)
FRRS1	NP_001013682.2	Reeler	32..155	CDD:307916	38/133 (29%)
		DOMON_SDR_2_like	192..354	CDD:187686	50/179 (28%)
		Cyt_b561_FRRS1_like	320..533	CDD:176490	77/228 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141357
Domainoid	1	1.000	125	1.000	Domainoid score	I5502
eggNOG	1	0.900	-	-		E1_KOG4293
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40653
Inparanoid	1	1.050	211	1.000	Inparanoid score	I3665
Isobase	1	0.950	-	0	Normalized mean entropy	S7160
OMA	1	1.010	-	-		QHG46024
OrthoDB	1	1.010	-	-		D464310at33208
OrthoFinder	1	1.000	-	-		FOG0001198
OrthoInspector	1	1.000	-	-		oto88349
orthoMCL	1	0.900	-	-		OOG6_102865
Panther	1	1.100	-	-	O	PTHR45828
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3670
SonicParanoid	1	1.000	-	-		X4013
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750