DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8399 and C09F9.2

DIOPT Version :9

Sequence 1:	NP_001286472.1	Gene:	CG8399 / 36768	FlyBaseID:	FBgn0034067	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_497053.1	Gene:	C09F9.2 / 182456	WormBaseID:	WBGene00007479	Length:	1642	Species:	Caenorhabditis elegans

Alignment Length:	629	Identity:	131/629 - (20%)
Similarity:	210/629 - (33%)	Gaps:	190/629 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MQALTMRSWLATLVTALLAVAIWPDPGQSLPQGAPETVCDTMLPFHSGGS---------VLPQNS 57
            :|..|::|...|.          |.|.|:.|......||.....:.:|.|         .:.:..
Worm   552 VQPTTLKSTAPTT----------PVPTQTAPPSVNGDVCYGDFRYPAGCSDCEYKLSWNYMEETD 606

  Fly    58 VSPFSVETSSSTLGQGQTLRVD---LTGVPAGLSFGGYMIQA-----RNRNPPHQI-----IGQF 109
            ...||:||           ||:   .|||  |.|..|.|:.|     ..||...|:     .|..
Worm   607 EIEFSLET-----------RVNDNSWTGV--GFSKDGTMVDADMIIVTTRNGKIQLNDMQSRGYD 658

  Fly   110 GPARDGTIKLMNCENSVNNSATHSNAGPKQQVILEWQSPVDFLGQVVFNATIAQSYNEFWVGVPS 174
            .||.|.   :.|.::|.:...|:||...:.|.:.:..:..|...|...::.....|
Worm   659 QPAMDA---VQNVKSSTDVIGTYSNGVLRAQFVRKVNTGDDTDKQFDGDSCWKMLY--------- 711

  Fly   175 QPV------QIVRRDLSAAPPLPTQSP--------SAPAGTTRAPYVPPSYVAPNNVVAVSSDPI 225
             |:      |.....:..:.||.:..|        ...|.|:.|...|.||...|.
Worm   712 -PIAGGKLDQYGNVSIHLSTPLSSDKPVCIRSCTGGKKATTSSASSAPASYTCTNE--------- 766

  Fly   226 YNGCGQSKNCFGFPDGCVATKSCTSI---TVVTVRGDVFEFEIQSGKGTNAAYVAVGLSDDAKMG 287
                      :.||:|| |.|.|..:   .|.:.:.|| .|||.:  .|...:..:|.|.|.:|.
Worm   767 ----------YRFPEGC-ADKDCDYVAKWNVDSAKKDV-RFEITA--KTPGRWTGIGFSRDGQMT 817

  Fly   288 D-DLTTECVPENGRVNLYSSLTSASPYSAV----RSNVNQNSARLLDASIVDGVIYCR--VQRDA 345
            : |:.|... .:|:..:...........|:    |.::.....::.|.  :..:.:.|  :.:|.
Worm   818 NADMYTGWF-FDGKAYIVDRFAYGRQLPAIDPADRQDIYDMGGKVEDD--LQTIWFRRKLISKDT 879

  Fly   346 VTNVQGRTFDLRNGKYHLL-VASGSSLKENS---------VGYHD-IGRLPSAQPINLAEV--QD 397
            .|:|     .|....|.|. |..|..|...|         :|||| :....||..|.|.:.  :.
Worm   880 KTDV-----SLDECHYFLFPVGGGRVLARKSSDFTNPKTPIGYHDQVQPQVSATKICLCDETGKT 939

  Fly   398 LSGSSRLLIQ--------------LHGAFMIAAWIGTTSLGII------FARYFKQTWVGSQSCG 442
            :|..::..|.              :|.|.|:...:......|:      .|...:.|:.|.::
Worm   940 VSHETKAPISRRVRRAATRVATSAMHCADMVVGMVSNGRARIMDMYSPSKATPMEDTFFGGEN-- 1002

  Fly   443 TDQWFAWHRLLMVTTWSLTVAA-------YVLIWVELKQA--VWHAHSIIGLITVI-------LC 491
                            |||.||       ..||:.:..||  .|....:.|.:|||       :.
Worm  1003 ----------------SLTSAAAFQEDGVTTLIFRKKLQAEEKWDNSFVNGPMTVIWAKGADPMN 1051

  Fly   492 FIQPIGALFRPGPNDKKRPYF--NWGHWLGGNLAHILGIVTIFF 533
            ::...|     |...|..|.|  |...:.|.|..   |::|:.|
Worm  1052 YVHTTG-----GAPIKAAPEFFENAMKYHGKNAR---GVMTVNF 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8399	NP_001286472.1	Reeler	40..170	CDD:280232	33/151 (22%)
		DOMON_SDR_2_like	223..392	CDD:187686	42/189 (22%)
		Cyt_b561_FRRS1_like	358..553	CDD:176490	48/227 (21%)
C09F9.2	NP_497053.1	TIL	320..383	CDD:280072
		TIL	393..447	CDD:280072
		TIL	494..548	CDD:280072
		DoH	592..745	CDD:214768	35/178 (20%)
		DoH	777..937	CDD:214768	37/170 (22%)
		DoH	<964..1056	CDD:214768	21/109 (19%)
		DoH	1127..1272	CDD:214768
		SEA	1347..>1431	CDD:295333
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4293
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810