DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8399 and LOC100491943

DIOPT Version :9

Sequence 1:	NP_001286472.1	Gene:	CG8399 / 36768	FlyBaseID:	FBgn0034067	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	XP_031756879.1	Gene:	LOC100491943 / 100491943	-ID:	-	Length:	594	Species:	Xenopus tropicalis

Alignment Length:	570	Identity:	172/570 - (30%)
Similarity:	256/570 - (44%)	Gaps:	87/570 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 QSLPQGAPETVCDTMLPFHSGGSVLPQNSVSPFSVETSSSTLGQGQTLRVDLTGVPAGLSFGGYM 93
            |....|.....||||:|.|...:.  |.|:||:.|..||.:...|..:.|.|. .....:|.|::
Frog    19 QPFGNGNVGLACDTMMPNHRTHAA--QESMSPYRVAASSYSFSPGDEITVTLL-ANFNTTFEGFL 80

  Fly    94 IQARNRNPPHQIIGQFGPARDGTIKLMNCENSVNNSATHSNAGPKQQVILEWQSPVDFLGQVVFN 158
            :|||:.. .::::|.|......: ::::|...:..:.:|.|...|..:...|.:| |....|.|.
Frog    81 LQARSVT-GNRLVGNFRVLNSNS-QILDCGGVMGLAVSHINTSKKSNITALWTAP-DLSDNVHFR 142

  Fly   159 ATIAQSYNEFWVGVPSQPVQIVRRDLSAAPPLPTQSPSAPAGTTRAPYVPPSYVAPNNVVA--VS 221
            ||..:::..|||||.|             |.|...:||....||  |.||..||...|:.:  |.
Frog   143 ATFVRNFKTFWVGVES-------------PLLTFITPSNQRPTT--PNVPAVYVLSTNLPSNKVG 192

  Fly   222 SDPI-YNGCGQSKNCFGFPDGCVATKSCT----SITVVTVRGDVFEFEIQSGKGTNAAYVAVGLS 281
            |..| ...||..|.||..|..|..::|..    |.:.:...|..:...|   .|.:..||:||.|
Frog   193 STIISRESCGTDKVCFSVPTDCDPSRSTNCYFMSSSPIETSGQGYLLGI---SGPSTGYVSVGFS 254

  Fly   282 DDAKMGDDLTTECVPENGRVNLYSSLTSASPYSAVRSN---VNQNSARLLDASIVDGVIYCRVQR 343
            ||.:||:|....||     :|....:.....||..:|.   :...:..::.||..:|:|.|
Frog   255 DDMQMGNDDMYLCV-----MNAAGVIEVQHAYSEGKSQPRVLTPGNIEVILASYNNGIIQC---- 310

  Fly   344 DAVTNVQGRTFDLR--------------NGKYHLLVASGSSLKENSVGYH-DIGRLPSAQPINLA 393
                     ||..|              |..||:.:|.||| ....|.|| ..||..|...|:|.
Frog   311 ---------TFIARSISILNPLQNSRSINSLYHIFLAYGSS-SNGQVQYHGPSGRFISNSRIDLL 365

  Fly   394 EVQDL-SGSSRL--LIQLHGAFMIAAWIGTTSLGIIFARYFKQTWVGSQ-SCGTDQWFAWHRLLM 454
            ...:: ||...|  |::.||:.|:.||:.|.|||:|.|||||.|  |.| ..|...||..|..||
Frog   366 AASNVTSGPYGLDPLVKAHGSLMLIAWMTTGSLGMILARYFKVT--GKQLVLGKAVWFQAHFFLM 428

  Fly   455 VTTWSLTVAAYVLIWVELKQAVWH----AHSIIGLITVILCFIQPIGALFRPGPNDKKRPYFNWG 515
            ..|...|:|::||.:|  |:..|:    .|:|||.|.:.|.|.||:.|||||.|...:|..|||.
Frog   429 ALTVCATIASFVLAFV--KEQGWNYNLSTHAIIGCIVMCLAFFQPLIALFRPSPQSSRRFIFNWF 491

  Fly   516 HWLGGNLAHILGIVTIFFSVKLPK---AELPEWMD----WILVSFVVVHV 558
            |.:...:..:|.:..:|..:::..   |.:||.|.    |..::|:.:.:
Frog   492 HVINALVIKVLAVANLFLGLQVVSHTYAWMPEVMGGFFAWEALAFISLEI 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8399	NP_001286472.1	Reeler	40..170	CDD:280232	35/129 (27%)
		DOMON_SDR_2_like	223..392	CDD:187686	51/191 (27%)
		Cyt_b561_FRRS1_like	358..553	CDD:176490	78/210 (37%)
LOC100491943	XP_031756879.1	Reeler	30..154	CDD:396550	35/129 (27%)
		DOMON_SDR_2_like	196..360	CDD:187686	50/185 (27%)
		Cyt_b561_FRRS1_like	333..541	CDD:176490	78/212 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8150
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D464310at33208
OrthoFinder	1	1.000	-	-		FOG0001198
OrthoInspector	1	1.000	-	-		otm47462
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010