DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8399 and zgc:163022

DIOPT Version :9

Sequence 1:	NP_001286472.1	Gene:	CG8399 / 36768	FlyBaseID:	FBgn0034067	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_001083026.2	Gene:	zgc:163022 / 100038777	ZFINID:	ZDB-GENE-070424-101	Length:	570	Species:	Danio rerio

Alignment Length:	551	Identity:	154/551 - (27%)
Similarity:	246/551 - (44%)	Gaps:	57/551 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 QSLPQGAPETVCDTMLPFHSGGSVLPQNSVSPFSVETSSSTLGQGQTLRVDLTGVPAGLSFGGYM 93
            ||...|....|||:|:|.|...:   |.|..||:|....:|..:|..::|.|.. ..|..|.|:|
Zfish    23 QSYKNGLVSEVCDSMMPNHGANA---QTSSPPFTVTADKTTFKEGDQIKVTLNS-QTGYYFEGFM 83

  Fly    94 IQARNRNP--PHQIIGQFGPARDGTIKLMNCENSVNNSATHSNAGPKQQVILEWQSPVD-FLGQV 155
            :|||   |  ....||.|. .....:::::|......:.:|::......|.:.|.:|.. .||.:
Zfish    84 LQAR---PVGSSSTIGTFS-VTGNNVQVLSCNGMPGRAVSHTSNAKTTSVQVTWTAPTSGQLGNI 144

  Fly   156 VFNATIAQSYNEFWVGVPSQPVQIVRRDLSAAPPLPTQSPSAPAGTTRAPYVPPSYVAPNNVVAV 220
            .|:.|..:|...|||.|.|..:..                :....||....|.|:         |
Zfish   145 EFSVTFVKSTLTFWVQVKSSAIVY----------------NGTITTTNTTTVAPT---------V 184

  Fly   221 SSDPIYNGCGQSKNCFGFPDGCVATKS--CTSITVVTVRGDVFEFEIQSGKGTNAAYVAVGLSDD 283
            :|.|   |||.:|.||..|:.|..|.|  |..:.|.| ..|..|.:|:. .|....|||:|.|||
Zfish   185 ASIP---GCGSTKVCFSEPNNCNPTTSNGCYFVAVQT-SSDQSEMKIEM-FGQADGYVAIGFSDD 244

  Fly   284 AKMGDDLTTECVPE-NGRVNLYSSLTSASPYSAVRSNVNQNSARLLDASIVDGVIYCR-VQRDAV 346
            .:||:|....|..: ||.:.:..:..|.....|:.|..|.::   :..::.:|.|.|. ..|:.:
Zfish   245 KEMGNDDVYICGKDNNGNLQVQHAFNSGKSSPAILSLGNVSN---IMTALTNGKINCSFTSRNTI 306

  Fly   347 TNVQGRTFDLRNGKYHLLVASGSSLKENSVGYHDIGRLPSAQPINLAEVQDLSGSSR---LLIQL 408
            :......   .|.:|||::|:||| .|..:.:| ..:..|:...||.....:..|..   .:::.
Zfish   307 STASRAA---SNNEYHLMIAAGSS-NEGKIQFH-TNKYVSSTKANLLNPSVVITSEEEFPPIVKA 366

  Fly   409 HGAFMIAAWIGTTSLGIIFARYFKQTWVGSQSCGTDQWFAWHRLLMVTTWSLTVAAYVLIWVELK 473
            ||..|:.:|:.|.|:|:|.|||.|....|...||.|.||..|..||..:...|..|:::::|...
Zfish   367 HGCLMLISWMATGSIGMIIARYLKGVAKGQGCCGKDFWFVAHVSLMTLSVIATAIAFIIVFVSAG 431

  Fly   474 QAVWHAHSIIGLITVILCFIQPIGALFRPGPNDKKRPYFNWGHWLGGNLAHILGIVTIFFSVKL- 537
            ..|..||.::|.:.:||..||||.|.||..|..::|..|||.|.........|.:..||..:.|
Zfish   432 DWVGGAHPVLGCLVMILSLIQPIVAAFRCEPQHERRFVFNWAHSCNAFAIKCLAVAAIFTGLALF 496

  Fly   538 PKAELPEWMDWILVSFVVVHVLVHLIFSIGL 568
            .:.:...||..::..::....|::::..:.|
Zfish   497 EEYDSDGWMLKVMGGYLAWEALMYILQDLNL 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8399	NP_001286472.1	Reeler	40..170	CDD:280232	36/132 (27%)
		DOMON_SDR_2_like	223..392	CDD:187686	50/172 (29%)
		Cyt_b561_FRRS1_like	358..553	CDD:176490	63/198 (32%)
zgc:163022	NP_001083026.2	Reeler	34..159	CDD:307916	36/132 (27%)
		DOMON_SDR_2_like	186..343	CDD:187686	51/169 (30%)
		Cyt_b561_FRRS1_like	314..525	CDD:176490	64/212 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574268
Domainoid	1	1.000	111	1.000	Domainoid score	I6184
eggNOG	1	0.900	-	-		E1_KOG4293
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3642
OMA	1	1.010	-	-		QHG46024
OrthoDB	1	1.010	-	-		D464310at33208
OrthoFinder	1	1.000	-	-		FOG0001198
OrthoInspector	1	1.000	-	-		otm26312
orthoMCL	1	0.900	-	-		OOG6_102865
Panther	1	1.100	-	-	O	PTHR45828
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4013
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770