DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8389 and slc16a10

DIOPT Version :9

Sequence 1:	NP_611076.2	Gene:	CG8389 / 36764	FlyBaseID:	FBgn0034063	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_001073497.1	Gene:	slc16a10 / 566499	ZFINID:	ZDB-GENE-040724-214	Length:	505	Species:	Danio rerio

Alignment Length:	493	Identity:	114/493 - (23%)
Similarity:	188/493 - (38%)	Gaps:	111/493 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PDGGYGWIVVAAVALINMTNQSILSVFGQLFVGELQKMQED-----TFTAALITNLNSLALNFSG 69
            |:||:||:|:.|....|.:...|.:.||.:||..|.:...:     .|..|.:.:| |:.:.|
Zfish    65 PEGGWGWVVMLASMWCNGSVFGIQNAFGIMFVYLLNEFGSEHDADLRFKTAWVGSL-SMGMIF-- 126

  Fly    70 LFIGPAIKSFKP----RNVAATGCILVALGLALCAFASESWHFILGYSFFVGFGLGLISPSTFMA 130
             |..|.:..|..    |..|..|..:..:||...:|.:........|......|.......:.:.
Zfish   127 -FCSPIVSVFTDLLGCRITAVGGAAVGCVGLLASSFVTSLGPMYFTYGIVFACGCSFAYQPSLVI 190

  Fly   131 INSYFTTKRGRAVGVSLAGAGLGQVLIPHLVRYLLDN----HGFRYAVLSMSSLSLFGLFGAAFL 191
            :..||..:.|...|:..||:.:..:.:|:::..||.:    |..|...:.|..|.|.||    ..
Zfish   191 LGHYFKRRLGLVNGIVTAGSSVFTITLPYMLSGLLKSVGLYHTLRVLAIFMFILMLAGL----TY 251

  Fly   192 KPLNPPAKHNNRKHIRLLTEADGEKTSPLQVVIVPTNQSKI-ERSPPNVDTLCSRMGQRLVQAMD 255
            |||.|.                            |.:.||. .|.||            |.:..:
Zfish   252 KPLLPK----------------------------PVSSSKPGSRCPP------------LSRIFN 276

  Fly   256 LELLKDLVF--WSIIVGMAL--VYTATINFTMIFPGFLGQTAQLNSQMVAFCMSLVAGADIVFRL 316
            :.:.|.|.:  |:..:..||  .:...::.........|..|  |.:::..|:.:.:|   |.||
Zfish   277 VNIWKSLGYRIWAFGIPAALYGYFVPYVHLMTHVEERFGPEA--NKEVLLACIGITSG---VGRL 336

  Fly   317 LLPIVTDHLRIP-YRVVFL-------IGIVGLFVARCVLAENQTLPVIITMSVLTGMMKSATVIN 373
            :...|.|:  :| ...|||       ||::.:.:..|     .....:|.:.:|.|:.....:
Zfish   337 IFGRVADY--VPGVNKVFLQVSSFMVIGVMSMMIPLC-----HVFGGLIAVCLLMGLFDGCFI-- 392

  Fly   374 NNLTISAHCRSEKLAG--------GLGLSMMSKGVIVITVG-QLLGWVRDYADSYLICLYAQGVI 429
               .|.|....| |.|        |..|.|||   |.:||| .:.|::||...||.:..|..|:.
Zfish   393 ---CIMAPIAFE-LVGSQNVSQAIGFLLGMMS---IPMTVGPPIAGFLRDRLGSYDVAFYLAGIP 450

  Fly   430 LLV--VVLVWTPEILYRHRRQRCA-----TNKSMETQS 460
            .|:  .||...|.:..|.:|:..|     |.|.:|::|
Zfish   451 PLIGGAVLCAIPWVEARRKRREAANTAENTEKMLESRS 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8389	NP_611076.2	MFS	19..425	CDD:119392	95/440 (22%)
CG8389	NP_611076.2	MFS_1	19..400	CDD:284993	86/414 (21%)
slc16a10	NP_001073497.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
		2A0113	56..458	CDD:273325	104/461 (23%)
		MFS	71..462	CDD:119392	102/459 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..505		5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820