DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8389 and CG8051

DIOPT Version :9

Sequence 1:	NP_611076.2	Gene:	CG8389 / 36764	FlyBaseID:	FBgn0034063	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_001285434.1	Gene:	CG8051 / 32925	FlyBaseID:	FBgn0031012	Length:	616	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	129/546 - (23%)
Similarity:	219/546 - (40%)	Gaps:	93/546 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DVQSSRVVPDGGYGWIVVAAVALINMTNQSILSVFGQLFVGELQKMQEDTFTAALITNLNSLALN 66
            |:....|.||||:||:|..|..:..:...::...||.||...:..:...:.....|.|.......
  Fly    72 DLGEDFVAPDGGWGWLVSVASGVNILVTFALAQQFGILFRDRMAGLGISSSELTTIINTQIAVSA 136

  Fly    67 FSGLFIGPAIKSFKPRNVAATGCILVALGLALCAFASESWHFILGYSFFVGFGLGLISPSTFMAI 131
            |:||..||..:.:..|.||..|.:|..|||....||.....:|:.:|...|||.||...::.:|:
  Fly   137 FTGLLNGPLFRRYTYRVVALVGSVLTFLGLFWMVFADTFAVYIMSFSILYGFGRGLTVSASSLAV 201

  Fly   132 NSYFTTKRGRAVGVSLAGAGLGQVLIPHLVRYLLDNHGFRYAVLSMSSLSLF------------- 183
            |:||..||..|.......||||.::.|:...|:|...|.:...|..:..||.
  Fly   202 NTYFKVKRRTATAFQFGVAGLGPIVCPYFATYMLYEFGVQGTTLLFAGASLHTIACSLIYQPVKW 266

  Fly   184 ---------------------------------------------GLFGA-AFLKP------LNP 196
                                                         |.||: |.|..      ||.
  Fly   267 HVVKRDRDAEALQQVQPLAEREDQDEDIIKNVVEPETPVLPRANDGWFGSRASLNSVGTRNRLNT 331

  Fly   197 PAKHNNRKHIRL--LTEADGEKTSPLQVVIVPTNQSKIERSPPNVD------TLCSRMGQRL--- 250
            ..|.::..|:.|  |:..|......|:.:.|..:..:.|.:..|.|      .|..:..|.|
  Fly   332 WEKSDSNGHVELKRLSSKDSNPGRQLRSISVSHSIKEEEATGYNSDHEVQHTELTEKEKQELEDE 396

  Fly   251 ---------------VQAMDLELLKDLVFWSIIVGMALVYTATINFTMIFPGFLGQTAQLNSQMV 300
                           |...|::||:|:.:.::.||:.|:....|||.::.| |:......|...:
  Fly   397 KERQRRKKLPFYMKVVIFFDMDLLRDITYVNLAVGITLINFVEINFAILTP-FILSDLGFNKDQI 460

  Fly   301 AFCMSLVAGADIVFRLLLPIVTDHLRIPYRVVFLIGIVGLFVARCVLAENQTLPVIITMSVLTGM 365
            |..||.:...|:|.|.|:|::|..:.:..|..|::||:|:.:.|..|:......|::.:.:..|:
  Fly   461 ALAMSTLGFFDLVVRFLIPLITAKINLSNRTFFVVGILGMCIGRMFLSMTSNFYVMMAIFLWLGL 525

  Fly   366 MKSATVINNNLTISAHCRSEKLAGGLGLSMMSKGVIVITVGQLLGWVRDYADSYLICLYAQGVIL 430
            .|:...:..:|.|.::...::|....||.::..|...:..|.|:|.:||:. ||.:.|.....:.
  Fly   526 NKAFRTVFWSLIIPSYVPLKRLPAAAGLQLLMSGTFSMIFGPLIGLIRDHT-SYAVTLNLLNALC 589

  Fly   431 LVVVLVWTPEILYRHRRQRCATNKSM 456
            ::....|..|...|.|.::....||:
  Fly   590 VMAFAGWYLEDFIRARSRKSPPVKSI 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8389	NP_611076.2	MFS	19..425	CDD:119392	114/496 (23%)
CG8389	NP_611076.2	MFS_1	19..400	CDD:284993	105/471 (22%)
CG8051	NP_001285434.1	MFS	86..>266	CDD:119392	49/179 (27%)
		MFS	<428..598	CDD:119392	43/171 (25%)
		MFS_1	440..>572	CDD:284993	34/132 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I2686
eggNOG	1	0.900	-	-		E1_KOG2504
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0010010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.920