DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8389 and Slc16a12

DIOPT Version :9

Sequence 1:	NP_611076.2	Gene:	CG8389 / 36764	FlyBaseID:	FBgn0034063	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_766426.1	Gene:	Slc16a12 / 240638	MGIID:	2147716	Length:	486	Species:	Mus musculus

Alignment Length:	470	Identity:	106/470 - (22%)
Similarity:	195/470 - (41%)	Gaps:	76/470 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PDGGYGWIVVAAVALINMTNQSILSVFGQLFVGELQK--MQEDTFTA----------ALITNLNS 62
            ||||:||::||...|:.:..:::.......|| |.|.  .|:.:.||          .|...|.|
Mouse    13 PDGGWGWMIVAGCFLVTICTRAVTRCISIFFV-EFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGS 76

  Fly    63 LALN----FSGLFIGPAIKSFKPRNVAATGCILVALGLALCAFASESWHFILGYSFFVGFGLGLI 123
            :..|    .:|:.:|.               :|.:.|..|.:||:...|..|......|.|..|.
Mouse    77 VVSNQLSCQAGIMLGG---------------LLASTGFILGSFATSLKHLYLSLGVLTGLGFALC 126

  Fly   124 SPSTFMAINSYFTTKRGRAVGVSLAGAGLGQVLIPHLVRYLLDNHGFRYAVLSMSSLSLFGLFGA 188
            .......:..||:.::..|.|::::|:|:|..::..:|:.|::...:|.|:|.:....|......
Mouse   127 YSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCG 191

  Fly   189 AFLKPL------NPPAKHNNRKHIRLLTEADGEKTSPLQVVIVPTNQSKIERSPPNVDTLCSRMG 247
            |.::|:      :.|.|::||:..|    .|.::.||...:.....::::         .||
Mouse   192 ALMRPITLKEDRSVPEKNHNRESQR----EDCKQASPYSPLTKECTETRL---------CCS--- 240

  Fly   248 QRLVQAMDLELLKDLVFWSIIVGMALVYTATINFTMIFPGFLGQTAQLNSQMVAFCMSLVAGADI 312
              |.|.....|:.|.|..::.| :.:.|..:..|..:.|..|  :..::....||.||::...||
Mouse   241 --LQQEYGFLLMSDFVVLAVSV-LFMAYGCSPLFVYLVPYAL--SVGVSHHQAAFLMSILGVIDI 300

  Fly   313 VFRLLLPIVTDHLRIP-YRVV---FLIGIVGLFVARCVLA--ENQTLPVIITMSVLTGMMKSATV 371
            |..:....:||...:. ||.|   |.:.:.||    |.|.  ..||.|:::..|...|....|.|
Mouse   301 VGNITFGWLTDRRCLKNYRYVCYLFAVALDGL----CYLCLPMLQTFPLLVPFSCTFGYFDGAYV 361

  Fly   372 INNNLTISAHCRSEKLAGGLGLSMMSKGVIVITVGQLLGWVRD----YADSYLICLYAQGVILLV 432
            ....:..:....:..|:..||:......|..:....:.||:.|    |..::|:|.:|   ::..
Mouse   362 TLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFA---MIFS 423

  Fly   433 VVLVWTPEILYRHRR 447
            .:|:....|:.|.:|
Mouse   424 SILLGFVRIVKRMKR 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8389	NP_611076.2	MFS	19..425	CDD:119392	95/437 (22%)
CG8389	NP_611076.2	MFS_1	19..400	CDD:284993	88/408 (22%)
Slc16a12	NP_766426.1	MFS_MCT12	18..431	CDD:340982	99/456 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920