DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8389 and SLC16A8

DIOPT Version :9

Sequence 1:	NP_611076.2	Gene:	CG8389 / 36764	FlyBaseID:	FBgn0034063	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_037488.2	Gene:	SLC16A8 / 23539	HGNCID:	16270	Length:	504	Species:	Homo sapiens

Alignment Length:	444	Identity:	103/444 - (23%)
Similarity:	164/444 - (36%)	Gaps:	65/444 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PDGGYGWIVVAAVALIN---MTNQSILSVFGQLFVGELQKMQEDTFTAALITNLNSLALNFSGLF 71
            ||||:||:|:.|..::.   ......:|||.:..:.:......||   |.::::....|..:|..
Human    13 PDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDT---AWVSSIMLAMLYGTGPV 74

  Fly    72 IGPAIKSFKPRNVAATGCILVALGLALCAFASESWHFILGYSFFVGFGLGL-ISPSTFMAINSYF 135
            ....:..|..|.|...|.:|.:.|:.|.:||:......|......|.||.| ..||..| :..||
Human    75 SSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIM-LGLYF 138

  Fly   136 TTKRGRAVGVSLAGAGLGQVLIPHLVRYLLDNHGFRYAVLSMSSLSLFGLFGAAFLKPLNPPAKH 200
            ..:|..|.|::.||:.:....:..|.:.||:..|:|...|.:..|.|......|.::|...|...
Human   139 ERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRPPPGPGPR 203

  Fly   201 NNRKHIRLL-------TEADGEKTSPLQVVIVPTNQSKIERSPPNVDTLCSRMGQRLVQAMDLEL 258
            ..|......       .||||   :.||          :..:.|.|     |..:||   :||.:
Human   204 PRRDSAGDRAGDAPGEAEADG---AGLQ----------LREASPRV-----RPRRRL---LDLAV 247

  Fly   259 LKDLVFWSIIVGMALVYTATINFTM----IFPGFL----GQTAQLNSQMVAFCMSLVAGADIVFR 315
            ..|..|        .||..| .|.|    ..|..|    .:.|.:.....||.:|:|...|||.|
Human   248 CTDRAF--------AVYAVT-KFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVAR 303

  Fly   316 LLLPIVTDHLRIPYRVVFLI-------GIVGLFVARCVLAENQTLPVIITMSVLTGMMKSATVIN 373
            .....:....|:...|.:|.       |:..|..||.     ::...::...|..|:........
Human   304 PACGALAGLARLRPHVPYLFSLALLANGLTDLSSARA-----RSYGALVAFCVAFGLSYGMVGAL 363

  Fly   374 NNLTISAHCRSEKLAGGLGLSMMSKGVIVITVGQLLGWVRDYADSYLICLYAQG 427
            ....:.|...:.:....|||.::.:...|:......|.:.|...:|.|..|..|
Human   364 QFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAG 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8389	NP_611076.2	MFS	19..425	CDD:119392	94/431 (22%)
CG8389	NP_611076.2	MFS_1	19..400	CDD:284993	89/406 (22%)
SLC16A8	NP_037488.2	2A0113	1..460	CDD:273325	103/444 (23%)
		MFS	19..429	CDD:119392	98/438 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..224		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920