DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8389 and SLC16A9

DIOPT Version :9

Sequence 1:	NP_611076.2	Gene:	CG8389 / 36764	FlyBaseID:	FBgn0034063	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	XP_016871372.1	Gene:	SLC16A9 / 220963	HGNCID:	23520	Length:	551	Species:	Homo sapiens

Alignment Length:	551	Identity:	120/551 - (21%)
Similarity:	207/551 - (37%)	Gaps:	137/551 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDVQSSRVVPDGGYGWIVVAAVALINMTNQ-----SILSVFGQLFVGELQKMQEDTFTAALITNL 60
            |:::.|   ||||:||::|    .::...|     |.|:| |.|::..|....|.....|.:.:|
Human     1 MELKKS---PDGGWGWVIV----FVSFLTQFLCYGSPLAV-GVLYIEWLDAFGEGKGKTAWVGSL 57

  Fly    61 NSLALNFSGLFIGP----AIKSFKPRNVAATGCILVALGLALCAFASESWHFILGYSFFVGFGLG 121
            .|..    ||...|    .:.||..|.|......:||.||.|.:||...:.....|...||.|.|
Human    58 ASGV----GLLASPVCSLCVSSFGARPVTIFSGFMVAGGLMLSSFAPNIYFLFFSYGIVVGLGCG 118

  Fly   122 LISPSTFMAINSYFTTKRGRAVGVSLAGAGLGQVLIPHLVRYLLDNHGFRYAVLSMSSLSLFGLF 186
            |:..:|......||..:||.|:|:...|:.:|..:...|.|.|::.:|....:|.:.:|:|..|.
Human   119 LLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCLLIVGALALNILA 183

  Fly   187 GAAFLKPLNP--------------PAKH--------NNRKHIRLLTEADGEKTSPLQVVIVPTN- 228
            ..:.::||..              |.|:        |..::|.:|   |...:|..:..|...|
Human   184 CGSLMRPLQSSDCPLPKKIAPEDLPDKYSIYNEKGKNLEENINIL---DKSYSSEEKCRITLANG 245

  Fly   229 ----QSKIERSPPNVDT---------------LCSRMGQRLVQ------AMDLELLKDLVFWSII 268
                .|.:.::|....|               .|.::.:|..|      ...:.|.|:.||.::.
Human   246 DWKQDSLLHKNPTVTHTKEPETYKKKVAEQTYFCKQLAKRKWQLYKNYCGETVALFKNKVFSALF 310

  Fly   269 VGMALVYTATINFTMIFPGFLGQTAQLNSQMVAFCMSLVAGADIVFRLLLPIVTDH--LRIPYRV 331
            :.:.|........:::.......:.....:.:...:|::.....|.:|||.|:.|.  :...|..
Human   311 IAILLFDIGGFPPSLLMEDVARSSNVKEEEFIMPLISIIGIMTAVGKLLLGILADFKWINTLYLY 375

  Fly   332 VFLIGIVGLFVARCVLAENQTLPVIITMSVLTGMMKSATVINNNLTISAHCRS-----EKLAGGL 391
            |..:.|:||.:.....|::     .:|:::|:|::...|   .|.:|..:..:     ||||...
Human   376 VATLIIMGLALCAIPFAKS-----YVTLALLSGILGFLT---GNWSIFPYVTTKTVGIEKLAHAY 432

  Fly   392 GLSMMSKGV-------IV----------ITV-------------------------GQLLGWVRD 414
            |:.|...|:       ||          .||                         |...||..|
Human   433 GILMFFAGLGNSLGPPIVGKIFILKSSHFTVLPCHISRYRGPDCNSSTDLYKRNLHGTSHGWFYD 497

  Fly   415 YADSYLICLYAQG--------VILLVVVLVW 437
            :..:|.|..|..|        ::||..:..|
Human   498 WTQTYDIAFYFSGFCVLLGGFILLLAALPSW 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8389	NP_611076.2	MFS	19..425	CDD:119392	107/511 (21%)
CG8389	NP_611076.2	MFS_1	19..400	CDD:284993	96/444 (22%)
SLC16A9	XP_016871372.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820