DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8388 and TRAF6

DIOPT Version :9

Sequence 1:	NP_611075.1	Gene:	CG8388 / 36763	FlyBaseID:	FBgn0034062	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_004611.1	Gene:	TRAF6 / 7189	HGNCID:	12036	Length:	522	Species:	Homo sapiens

Alignment Length:	372	Identity:	71/372 - (19%)
Similarity:	129/372 - (34%)	Gaps:	105/372 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 NTSCLPKIQ-KSQEFNDYIREHYKVQCHICNLPMEDFSEMLAHVRREHKQRGYAMCCNRKFLKRG 272
            ::|.:.:|| ...||:..:...|  :|.||.:.:           ||..|..    |..:|.|..
Human    46 SSSFMEEIQGYDVEFDPPLESKY--ECPICLMAL-----------REAVQTP----CGHRFCKAC 93

  Fly   273 VL-----------VDH---LRRHQDPETF----------KCSICGRVMGHRRSLELHMRMHEIKS 313
            ::           ||:   |.....|:.|          ||...|.:  |:..|. |:..|:...
Human    94 IIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNEGCL--HKMELR-HLEDHQAHC 155

  Fly   314 RGRLYRCEQCSKAFYSAVVYERHKLTHIPREQWKVPCTHC--EKTYPSQYTMQQHVKLVHLNLYA 376
            ...|..|.||.:.|....: ..|.|...||.|  |.|.:|  ...:..:....|:..|.::
Human   156 EFALMDCPQCQRPFQKFHI-NIHILKDCPRRQ--VSCDNCAASMAFEDKEIHDQNCPLANV---- 213

  Fly   377 KICDVCGKSIRGREALARHMEEHTGGPQAAIKCHLCDSMLTTKYGLARHIKMMHTAENLQPMQCE 441
             ||:.| .:|..||.:..|.:  ...|.|.|.|..      :.:|....::..|.|.:||
Human   214 -ICEYC-NTILIREQMPNHYD--LDCPTAPIPCTF------STFGCHEKMQRNHLARHLQ----- 263

  Fly   442 FCLKICPSLQAHQHHIKYTHNTARSHQCPMCEKAFKRPNELKEHMTTHTGEVLYTCPHCPQTFNS 506
                               .|| :||...:.:             ..|:..|:....:..:..|.
Human   264 -------------------ENT-QSHMRMLAQ-------------AVHSLSVIPDSGYISEVRNF 295

  Fly   507 NANMHAHRKKVHRKEWEENRHKRLNRSRKSDTIIAVSVRKTTETRQD 553
            ...:|....::.|   ::::.:.|....::.::....:::|..|.:|
Human   296 QETIHQLEGRLVR---QDHQIRELTAKMETQSMYVSELKRTIRTLED 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8388	NP_611075.1	zf-AD	<21..77	CDD:285071
		C2H2 Zn finger	264..281	CDD:275368	6/30 (20%)
		C2H2 Zn finger	289..309	CDD:275368	5/19 (26%)
		C2H2 Zn finger	320..340	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..369	CDD:275368	3/20 (15%)
		C2H2 Zn finger	440..461	CDD:275368	0/20 (0%)
		C2H2 Zn finger	469..489	CDD:275368	0/19 (0%)
		C2H2 Zn finger	497..515	CDD:275368	2/17 (12%)
TRAF6	NP_004611.1	Interaction with TAX1BP1. /evidence=ECO:0000269\|PubMed:10920205	1..354		71/372 (19%)
		RING	69..107	CDD:238093	9/52 (17%)
		zf-TRAF	204..261	CDD:280357	16/70 (23%)
		MATH_TRAF6	351..500	CDD:239745
		Interaction with TANK. /evidence=ECO:0000269\|PubMed:25861989	355..522
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000