DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8388 and ZNF335

DIOPT Version :9

Sequence 1:	NP_611075.1	Gene:	CG8388 / 36763	FlyBaseID:	FBgn0034062	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_071378.1	Gene:	ZNF335 / 63925	HGNCID:	15807	Length:	1342	Species:	Homo sapiens

Alignment Length:	586	Identity:	129/586 - (22%)
Similarity:	210/586 - (35%)	Gaps:	147/586 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 QLLLFHNFYLNVEQAHKALEQTVLKETSPPEVVASALEEHIVKSEHDDSVAAAVKRRRGRPRKVA 121
            ::::...|...:.|...:.:.|:|:...         |.|.    ...:.|||...::||.||.:
Human   238 EVVVVQQFKCKMCQYRSSTKATLLRHMR---------ERHF----RPVAAAAAAAGKKGRLRKWS 289

  Fly   122 QQDAREELKSVLEQINLNEIKIEFPEADLTIADVLED-QEEQDFLPDDCISKEGAEDP---EVLE 182
            .....:|.:...|:          .:.|:..|..::| :|:.|:.|        |||.   ..|.
Human   290 TSTKSQEEEGPEEE----------DDDDIVDAGAIDDLEEDSDYNP--------AEDEPRGRQLR 336

  Fly   183 KKPPT----LKRKVSGRSRGRRRVQLAERP------------NTSCLPKIQKSQEFNDYIREHYK 231
            .:.||    ..|:..||.|...|:::::.|            :....|:.|..:..:.....|..
Human   337 LQRPTPSTPRPRRRPGRPRKLPRLEISDLPDGVEGEPLVSSQSGQSPPEPQDPEAPSSSGPGHLV 401

  Fly   232 VQCHICNLPME------DFSEMLAHVRREH-----------------KQRGY-----------AM 262
            ....:...|:|      |..........||                 |.|.|           .:
Human   402 AMGKVSRTPVEAGVSQSDAENAAPSCPDEHDTLPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPFL 466

  Fly   263 C--CNRKFLKRGVLVDHLRRHQ--DPETFKCSICGRVMGHRRSLELHMRMHEIKSRGRLYRCEQC 323
            |  |..:||....|..|:..|:  ||:.|||..|........||:.||..| :.|:.  |:|::|
Human   467 CRICGSRFLSHEDLRFHVNSHEAGDPQLFKCLQCSYRSRRWSSLKEHMFNH-VGSKP--YKCDEC 528

  Fly   324 SKAFYSAVVYE---RHKLTHIPREQWK----------VPCTHCEKTYPSQYTMQQHVKLVHLNLY 375
            |   |::|..:   ||...| .|::.|          .||..|.:.||.|..:.||:| .|....
Human   529 S---YTSVYRKDVIRHAAVH-SRDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMK-THSTEK 588

  Fly   376 AKICDVCGKSIRGREALARHMEEHTGGPQAAIKCHLCDSMLTTKYGLARHIKMMHTAENLQPMQC 440
            ..:||.||||.:.|.....|:..|.   ||...               |..|            |
Human   589 PHMCDKCGKSFKKRYTFKMHLLTHI---QAVAN---------------RRFK------------C 623

  Fly   441 EFCLKICPSLQAHQHHIKYTHNTARSHQCPMCEKAFKRPNELKEHMTT-HTGEVLYTCPHCPQTF 504
            |||..:|...:|..:| :.:|.:.:..:|..|.....|.:.|..|:.. |||...:.|.:|..:.
Human   624 EFCEFVCEDKKALLNH-QLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFST 687

  Fly   505 NSNANMHAHRKKVHRKEWEE--NRHKRLNRSRKSDTIIAVSVRKTTETRQDGGLVPAEAIATTSS 567
            ....|:..|.:..|...:||  .||.....||:....   |:::..|.:|.....|....::...
Human   688 RHKKNLRLHVRCRHASSFEEWGRRHPEEPPSRRRPFF---SLQQIEELKQQHSAAPGPPPSSPGP 749

  Fly   568 P 568
            |
Human   750 P 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8388	NP_611075.1	zf-AD	<21..77	CDD:285071	2/19 (11%)
		C2H2 Zn finger	264..281	CDD:275368	5/16 (31%)
		C2H2 Zn finger	289..309	CDD:275368	6/19 (32%)
		C2H2 Zn finger	320..340	CDD:275368	7/22 (32%)
		C2H2 Zn finger	350..369	CDD:275368	7/18 (39%)
		C2H2 Zn finger	440..461	CDD:275368	7/20 (35%)
		C2H2 Zn finger	469..489	CDD:275368	5/20 (25%)
		C2H2 Zn finger	497..515	CDD:275368	4/17 (24%)
ZNF335	NP_071378.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..102
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..228
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..442		35/185 (19%)
		C2H2 Zn finger	467..487	CDD:275368	6/19 (32%)
		C2H2 Zn finger	497..517	CDD:275368	6/19 (32%)
		zf-H2C2_2	509..534	CDD:290200	11/30 (37%)
		C2H2 Zn finger	529..545	CDD:275370	5/18 (28%)
		C2H2 Zn finger	564..584	CDD:275368	8/20 (40%)
		zf-H2C2_2	577..600	CDD:290200	10/23 (43%)
		zf-C2H2	590..612	CDD:278523	8/21 (38%)
		C2H2 Zn finger	592..612	CDD:275368	8/19 (42%)
		C2H2 Zn finger	623..643	CDD:275368	7/20 (35%)
		C2H2 Zn finger	651..672	CDD:275368	5/20 (25%)
		C2H2 Zn finger	680..699	CDD:275368	4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..763		3/19 (16%)
		PRK04654	<795..911	CDD:135173
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1013
		C2H2 Zn finger	1021..1041	CDD:275368
		Involved in the interaction with CCAR2. /evidence=ECO:0000269\|PubMed:19131338	1041..1342
		C2H2 Zn finger	1049..1069	CDD:275368
		zf-H2C2_5	1075..1097	CDD:290620
		C2H2 Zn finger	1077..1097	CDD:275368
		zf-H2C2_2	1089..1114	CDD:290200
		C2H2 Zn finger	1105..1126	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144316
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940