DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8388 and ZFP64

DIOPT Version :9

Sequence 1:	NP_611075.1	Gene:	CG8388 / 36763	FlyBaseID:	FBgn0034062	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_060667.2	Gene:	ZFP64 / 55734	HGNCID:	15940	Length:	681	Species:	Homo sapiens

Alignment Length:	586	Identity:	120/586 - (20%)
Similarity:	193/586 - (32%)	Gaps:	193/586 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ASEEADSL--------GLRCIIEKHFWLQIPDSKRAGYVCGPCWEQLLLFHNFYLNVEQAHKALE 76
            ||.|.:|.        |...::|     ..||.    ::||.|.:|   |:|  |:...|||...
Human     3 ASSEGESFAGSVQIPGGTTVLVE-----LTPDI----HICGICKQQ---FNN--LDAFVAHKQSG 53

  Fly    77 -QTVLKETSPPEVVASALEEHIVKSEHDDSVAAAVKRRRGRPRKVAQQDAREELKSVLEQINLNE 140
             |......:.|..|....||.:..::                    .|.....:.|..:.|.::.
Human    54 CQLTGTSAAAPSTVQFVSEETVPATQ--------------------TQTTTRTITSETQTITVSA 98

  Fly   141 IKIEFPEADLTIADVLEDQEEQDFLPDDCISKEGAEDPEVLEKKPPTLKRKVSGRSRGRRRVQLA 205
            .:..|            :...|.:||           .|..|.:..|:   :|..::.|     .
Human    99 PEFVF------------EHGYQTYLP-----------TESNENQTATV---ISLPAKSR-----T 132

  Fly   206 ERPNTSCLPKIQKSQEFNDYIREHYKVQCHICNLPMEDFSEMLAHVRREHKQRGYAMCCNRKFLK 270
            ::|.|   |..||...               |..|...|            :..|.|    |.::
Human   133 KKPTT---PPAQKRLN---------------CCYPGCQF------------KTAYGM----KDME 163

  Fly   271 RGVLVDHLRRHQDPETFKCSICGRVMGHRRSLELHMRMHE-IKSRGRLYRCEQCSKAFYSAVVYE 334
            |     ||:.|...:..||.:||:....:..|:.|||.|. :|.    |:|:.|..|...:....
Human   164 R-----HLKIHTGDKPHKCEVCGKCFSRKDKLKTHMRCHTGVKP----YKCKTCDYAAADSSSLN 219

  Fly   335 RHKLTHIPREQWKVPCTHCEKTYPSQYTMQQHVKLVHLNLYAK----ICDVCGKSIRGREALARH 395
            :|...|.....:|  |..|  .|.|:.:.|   ..|||..:..    .|.:|....:....|.||
Human   220 KHLRIHSDERPFK--CQIC--PYASRNSSQ---LTVHLRSHTGDAPFQCWLCSAKFKISSDLKRH 277

  Fly   396 MEEHTGGPQAAIKCHLCDSMLTTKYGLARHIKMMHTAENLQ------------------------ 436
            |..|:|  :...||..|:...|.|..|..||::.|:..|.:
Human   278 MRVHSG--EKPFKCEFCNVRCTMKGNLKSHIRIKHSGNNFKCPHCDFLGDSKATLRKHSRVHQSE 340

  Fly   437 -PMQCEFCLKICPSLQAHQHHIKYTHNTARSHQCPMCEKAFKRPNELKEHMTTHTGEVLYT---- 496
             |.:|..|...|.|..|.:.| :..|.|.|..:|..|....|:|:.|.:||....|:::.|
Human   341 HPEKCSECSYSCSSKAALRIH-ERIHCTDRPFKCNYCSFDTKQPSNLSKHMKKFHGDMVKTEALE 404

  Fly   497 ----------------------CPHCPQTFNSNANMHAHRKKVHRKEWEENRHKRLNRSRKSDTI 539
                                  |..|..:|....::.:|::          :|...:.|:.||..
Human   405 RKDTGRQSSRQVAKLDAKKSFHCDICDASFMREDSLRSHKR----------QHSEYSESKNSDVT 459

  Fly   540 I 540
            :
Human   460 V 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8388	NP_611075.1	zf-AD	<21..77	CDD:285071	17/64 (27%)
		C2H2 Zn finger	264..281	CDD:275368	4/16 (25%)
		C2H2 Zn finger	289..309	CDD:275368	7/19 (37%)
		C2H2 Zn finger	320..340	CDD:275368	4/19 (21%)
		C2H2 Zn finger	350..369	CDD:275368	5/18 (28%)
		C2H2 Zn finger	440..461	CDD:275368	6/20 (30%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		C2H2 Zn finger	497..515	CDD:275368	4/17 (24%)
ZFP64	NP_060667.2	COG5048	<151..450	CDD:227381	75/343 (22%)
		zf-H2C2_2	161..186	CDD:290200	8/29 (28%)
		C2H2 Zn finger	177..197	CDD:275368	7/19 (37%)
		zf-H2C2_2	190..211	CDD:290200	9/24 (38%)
		C2H2 Zn finger	205..225	CDD:275368	4/19 (21%)
		zf-H2C2_2	217..239	CDD:290200	5/25 (20%)
		C2H2 Zn finger	233..253	CDD:275368	8/24 (33%)
		C2H2 Zn finger	261..281	CDD:275368	6/19 (32%)
		zf-H2C2_2	273..297	CDD:290200	9/25 (36%)
		C2H2 Zn finger	289..308	CDD:275368	7/18 (39%)
		C2H2 Zn finger	373..391	CDD:275368	6/17 (35%)
		zf-C2H2_6	425..450	CDD:290623	5/34 (15%)
		C2H2 Zn finger	427..447	CDD:275368	4/29 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144325
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030