DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8388 and wek

DIOPT Version :9

Sequence 1:	NP_611075.1	Gene:	CG8388 / 36763	FlyBaseID:	FBgn0034062	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001260472.1	Gene:	wek / 48785	FlyBaseID:	FBgn0001990	Length:	470	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	121/569 - (21%)
Similarity:	197/569 - (34%)	Gaps:	177/569 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CFLCTQTVDDAAGNIEFASEEADSLGLRCIIEKHFWLQ--IPDSKRAGYVCGPCWE---QLLLFH 62
            |.||.:  ||....:.   |..|.| :| ||.|.|.::  :.:.:....:|..|:.   ||:.|.
  Fly    12 CRLCAR--DDVVYKVR---ERDDDL-VR-IISKCFDVEMTLEEPELGSMLCEECYSVIGQLITFS 69

  Fly    63 NFYLNVE-----------QAHKALEQTVLKETSPPEVVAS-------------ALEEHIVKSEHD 103
            :....|:           |..:.|:...|:...||.....             :|.|.:..|:|.
  Fly    70 DSVSKVQAIFELLRHSEPQDSQDLDALRLEYGLPPACKQDLEFLDIDDTEDRCSLVEELTISDHS 134

  Fly   104 DSVAAAVKRRRGRPRKVAQQDAREELKSVLEQINLNEIKIEFPEADLTIADVLEDQEEQDFLPDD 168
            .|.:...:.:..|.|            :.|:|.|.:...:..|.|.:...:....:.:|.....:
  Fly   135 TSPSPDFEAQTVRTR------------ANLKQCNSDPKVLASPTASIPEVETKRSRRQQFAAKRN 187

  Fly   169 C---ISKEGAEDPEVLEK----KPPTLKRKVSGRSRGRRRVQLAERPNTSCLPKIQKSQEFNDYI 226
            .   .:.|..::..:|::    .||.|||| .||.:|..:               ||:.:.:|.:
  Fly   188 SKVYTATESDDEEAILDEDEAVSPPPLKRK-RGRPKGSGK---------------QKNVDDSDNV 236

  Fly   227 REHYKVQCHICNLPMEDFSEMLAHVRREHKQRGYAMCCNRKFLKRGVLVDHLRRHQDPETFKCSI 291
                                    ..||..                   |:.:..||.:|
  Fly   237 ------------------------TSREPD-------------------DNAKSKQDDKT----- 253

  Fly   292 CGRVMGHRRSLELHMRMHEIKSRGRL-YRCEQCSKAFYSAVVYERHK--LTHIPREQWKVPCTHC 353
                      .||.|..|..:|...: |.|:.|::.|.|.:...|||  :...|:   |..|.||
  Fly   254 ----------SELSMSPHGSQSSNFVDYPCKICNETFMSFMALRRHKHDMHGGPK---KYVCDHC 305

  Fly   354 EKTYPSQYTMQQHVKLVHLNLYAKICDVCGKSIRGREALARHMEEHTGGPQAAIKCHLCDSMLTT 418
            .|...:..::.:| :|||......||.||....:.:..|..|.:.| |.|:  .:|::|...|.|
  Fly   306 GKGLKTFTSLVEH-QLVHTEEKPCICPVCNAGFKNKARLRVHSQTH-GEPK--FECNVCGKKLQT 366

  Fly   419 KYGLARHIKMMHTAENLQPMQCEFCLKICPSLQAHQHHIKYTHNTARSHQCPMCEKAFKRPNELK 483
            :..|.:|                                ||.|...|..:|.:|....|....||
  Fly   367 RAILNKH--------------------------------KYVHTDERRFKCEVCGSGCKNSTALK 399

  Fly   484 EHMTTHTGEVLYTCPHCPQTFNSNANMHAHRKKVH------RKEWEENR 526
            .|:..|||...|.|.:|.:.|.||.|..:|:.|.|      ..|.|.:|
  Fly   400 IHLLGHTGLRPYVCKYCGKAFASNTNCRSHKWKKHPELASKEDETESSR 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8388	NP_611075.1	zf-AD	<21..77	CDD:285071	16/71 (23%)
		C2H2 Zn finger	264..281	CDD:275368	1/16 (6%)
		C2H2 Zn finger	289..309	CDD:275368	3/19 (16%)
		C2H2 Zn finger	320..340	CDD:275368	7/21 (33%)
		C2H2 Zn finger	350..369	CDD:275368	5/18 (28%)
		C2H2 Zn finger	440..461	CDD:275368	2/20 (10%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		C2H2 Zn finger	497..515	CDD:275368	7/17 (41%)
wek	NP_001260472.1	zf-AD	11..80	CDD:214871	19/74 (26%)
		C2H2 Zn finger	273..294	CDD:275368	7/20 (35%)
		C2H2 Zn finger	302..322	CDD:275368	6/20 (30%)
		C2H2 Zn finger	330..350	CDD:275368	5/19 (26%)
		C2H2 Zn finger	357..377	CDD:275368	8/51 (16%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	397..422	CDD:290200	10/24 (42%)
		C2H2 Zn finger	413..429	CDD:275368	6/15 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471730
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840