DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8388 and traf3

DIOPT Version :9

Sequence 1:	NP_611075.1	Gene:	CG8388 / 36763	FlyBaseID:	FBgn0034062	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001003513.1	Gene:	traf3 / 445119	ZFINID:	ZDB-GENE-040801-257	Length:	573	Species:	Danio rerio

Alignment Length:	395	Identity:	77/395 - (19%)
Similarity:	129/395 - (32%)	Gaps:	134/395 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 SRGR---RRVQLAERPNTSCLPKIQKS-------QEFNDYIREHY------KVQCHICNLPMEDF 244
            |.||   :::.|.:||.:..:|.:.:.       ...:...|:|:      |..|..|.|
Zfish     2 SAGRNVEQQIPLQQRPPSLAMPSMAQRPRPEPGFSPLHGGFRDHFVTTPEPKYCCETCRL----- 61

  Fly   245 SEMLAHVRREHKQRGYAMC--CNRKFLKRGVLV---DHLRRHQDPETFKCSICGRVMGHRRSLEL 304
              :|.:.|:  .:.|:..|  |..:.|.:...|   |.|...:| :.|:...|.|.:   .:|::
Zfish    62 --VLCNPRQ--TECGHRFCESCINELLSKPNPVCPADLLPLFED-KIFRDVCCNREI---MALKV 118

  Fly   305 HMRMHEIKSRGRLYRCEQCSKAFYSAVVYERHKLTHIPREQWKVPCT--HCEKTYPSQYTMQQHV 367
            :.|..:          ..|.:......|.|.  |...|  .::|||.  .| |....:..|.:|:
Zfish   119 YCRSEK----------NGCKEQMCLQQVMEH--LVICP--YFEVPCPLGKC-KEKMMRKDMPEHL 168

  Fly   368 --KLVHLNLYAKICDVCGKSIRGREALARHMEEHTGGPQAAIKCHLCDSMLTTKYGLARHIKMMH 430
              |..|..:   .|:.|...:...| |.:|.|  |..|...:.|
Zfish   169 SRKCKHREV---TCEFCSLKMALTE-LQKHKE--TVCPAFPVAC--------------------- 206

  Fly   431 TAENLQPMQCEFCLKICPSLQAHQHHIKYTHNTARSHQCPMCEK---------AFKRPN-ELKEH 485
                  |..|.|...:...|.:||            |.||..:.         ::|..| |::||
Zfish   207 ------PNHCSFSSILRSELSSHQ------------HDCPKAQVTCSFIRYGCSYKGLNQEMREH 253

  Fly   486 MTTHTGEVLYTCPHCPQTFNSNANMHA----------HRKKV----------HRKEWEENRHKRL 530
            .::...|      |.......|..:.|          .|.||          ..:::||.|.|..
Zfish   254 ESSFASE------HLRMMAVRNTTLEAKVEDVKSELMERYKVLPSLSSRLAEVERQYEEMREKNR 312

  Fly   531 NRSRK 535
            ...:|
Zfish   313 QLEQK 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8388	NP_611075.1	zf-AD	<21..77	CDD:285071
		C2H2 Zn finger	264..281	CDD:275368	5/19 (26%)
		C2H2 Zn finger	289..309	CDD:275368	4/19 (21%)
		C2H2 Zn finger	320..340	CDD:275368	4/19 (21%)
		C2H2 Zn finger	350..369	CDD:275368	5/22 (23%)
		C2H2 Zn finger	440..461	CDD:275368	5/20 (25%)
		C2H2 Zn finger	469..489	CDD:275368	7/29 (24%)
		C2H2 Zn finger	497..515	CDD:275368	3/27 (11%)
traf3	NP_001003513.1	RING	55..92	CDD:214546	10/45 (22%)
		zf-TRAF	139..194	CDD:280357	15/63 (24%)
		zf-TRAF	198..253	CDD:280357	14/93 (15%)
		Prefoldin	<249..322	CDD:298833	15/75 (20%)
		MATH_TRAF3	383..568	CDD:239746
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000