back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8388 and prdm9

DIOPT Version :9

Sequence 1:	NP_611075.1	Gene:	CG8388 / 36763	FlyBaseID:	FBgn0034062	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_957196.1	Gene:	prdm9 / 393876	ZFINID:	ZDB-GENE-040426-1319	Length:	853	Species:	Danio rerio

Alignment Length:	626	Identity:	133/626 - (21%)
Similarity:	204/626 - (32%)	Gaps:	201/626 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TQTVD--DAAGNIEFASEEADSLG---------LR-CIIEKHFWLQIPDSKRAGYVCG---PCWE 56
            |:..|  ||:.....|.|.:|.:.         || |.:::|  .:...||...|.|.   .|:.
Zfish   314 TENSDEPDASDIYTAAGEISDEIHACVDCGRSFLRSCHLKRH--QRTIHSKEKPYCCSQCKKCFS 376

  Fly    57 QL--LLFHNFYLNVEQAHKALEQTVLKETSPPEV----------VASA-LEEHIVKSEHDDSVAA 108
            |.  |..|      :..|:..|:.:.....|.::          ||.. |.:|:.:..|.
Zfish   377 QATGLKRH------QHTHQEQEKNIESPDRPSDIYPCTKCTLSFVAKINLHQHLKRHHHG----- 430

  Fly   109 AVKRRRGRPRKVAQQDAREELKSVLEQINLNEIKIEFPEADLTIADVLEDQEEQDFLPDDCISKE 173
                              |.|:.|              |:....|:..||..|.      |..|
Zfish   431 ------------------EYLRLV--------------ESGSLTAETEEDHTEV------CFDK- 456

  Fly   174 GAEDPEVLEKKPPTLKRKVS---------------GRSRGRRRVQLAERPNTSCLPKIQKSQEFN 223
              :||..   :||:..||.:               ||.|||              |...|:.|.
Zfish   457 --QDPNY---EPPSRGRKSTKNSLKGRGCPKKVAVGRPRGR--------------PPKNKNLEV- 501

  Fly   224 DYIREHYKVQ--CHICNLPMEDFSEMLAH--VRR-------EHKQRGYAMCCN---RKFLKRGVL 274
                |..|:.  |..|.....|...:..|  .||       ||.|......|.   |.|....:|
Zfish   502 ----EVQKISPICTNCEQSFSDLETLKTHQCPRRDDEGDNVEHPQEASQYICGECIRAFSNLDLL 562

  Fly   275 VDHLRRHQDPETFKCSICGRVMGHRRSLELHMRMHEIKSRGRLYRCEQCSKAFYSAVVYERHKLT 339
            ..|....|...::.|..|........:|..|.|  .|.|:.:.|.|..|.|:|..:...:||:.:
Zfish   563 KAHECIQQGEGSYCCPHCDLYFNRMCNLRRHER--TIHSKEKPYCCTVCLKSFTQSSGLKRHQQS 625

  Fly   340 HIPREQWK----------VPCTHCEKTYPSQYTMQQHVKLVHLNLYAK----------------- 377
            |:.|:..:          .||.:|..::..:..:.:|::..|..:..|
Zfish   626 HLRRKSHRQSSALFTAAIFPCAYCPFSFTDERYLYKHIRRHHPEMSLKYLSFQEGGVLSVEKPHS 690

  Fly   378 ---------------------------ICDVCGKSIRGREALARHMEEHTGGPQAAIKCHLCDSM 415
                                       :|..|||:.....:|.:|...|||  :....|..|...
Zfish   691 CSQCCKSFSTIKGFKNHSCFKQGEKVYLCPDCGKAFSWFNSLKQHQRIHTG--EKPYTCSQCGKS 753

  Fly   416 LTTKYGLARHIKMMHTAENLQPMQCEFC---LKICPSLQAHQHHIKYTHNTARSHQCPMCEKAFK 477
            ......|..|:: .||.|  :|..|..|   .:....|:.|:.    .|:..|..|||.|.|:|.
Zfish   754 FVHSGQLNVHLR-THTGE--KPFLCSQCGESFRQSGDLRRHEQ----KHSGVRPCQCPDCGKSFS 811

  Fly   478 RPNELKEHMTTHTGEVLYTCPHCPQTFNSNANMHAHRKKVH 518
            ||..||.|...|.|..|:.|..|.::|....::..|.:|:|
Zfish   812 RPQSLKAHQQLHVGTKLFPCTQCGKSFTRRYHLTRHHQKMH 852

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.