DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8388 and ZNF805

DIOPT Version :9

Sequence 1:	NP_611075.1	Gene:	CG8388 / 36763	FlyBaseID:	FBgn0034062	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001018857.2	Gene:	ZNF805 / 390980	HGNCID:	23272	Length:	627	Species:	Homo sapiens

Alignment Length:	594	Identity:	138/594 - (23%)
Similarity:	216/594 - (36%)	Gaps:	137/594 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TVDDAAGNIEFASEEADSLGLRCIIEKHFWLQIPDSKRAGYV------CG-------PCWEQLLL 60
            |.||.|  :.|..||              |.|:..::|..|.      ||       |.....|:
Human    14 TFDDVA--VTFTQEE--------------WGQLDLAQRTLYQEVMLENCGLLVSLGCPVPRPELI 62

  Fly    61 FHNFYLNVEQAHKALEQTVLKETSP----------PEVVASALEE------HIVKSEHDDSVAAA 109
            :|   |...|.....::.:.:.|.|          |.....||.|      .:.:....||
Human    63 YH---LEHGQEPWTRKEDLSQGTCPGDKGKPKSTEPTTCELALSEGISFWGQLTQGASGDS---- 120

  Fly   110 VKRRRGRPRKVAQQDAREELKSVLEQINLNEIKIEFP-----------EADLTIADVLEDQEEQD 163
               :.|:|:   .||...|::....:..|:..|.:.|           .||...:.:::|:....
Human   121 ---QLGQPK---DQDGFSEMQGERLRPGLDSQKEKLPGKMSPKHDGLGTADSVCSRIIQDRVSLG 179

  Fly   164 FLPDDCISKEGAEDPEVLEKKPPTLK----RKVSGRSR---GRRRVQLAERPN--TSCLPKIQKS 219
            ....||.|....::| |::::....|    .||..:.|   ...|:....:|.  |.|.....||
Human   180 DDVHDCDSHGSGKNP-VIQEEENIFKCNECEKVFNKKRLLARHERIHSGVKPYECTECGKTFSKS 243

  Fly   220 QEFNDYIREHYKVQCHICNLPMEDFSEMLAHVRREHKQRGYAMCCNRKFLKRGVLVDHLRRHQDP 284
                .|:.:|:.|  |....|.:                  .|.|.:.|.::..|..|.|.|...
Human   244 ----TYLLQHHMV--HTGEKPYK------------------CMECGKAFNRKSHLTQHQRIHSGE 284

  Fly   285 ETFKCSICGRVMGHRRSLELHMRMHEIKSRGRLYRCEQCSKAFYSAVVYERHKLTHIPREQWKVP 349
            :.:|||.||:...||.:..||.|.|   :..:.:.|::|.|||.....:.||.:.|.....::
Human   285 KPYKCSECGKAFTHRSTFVLHNRSH---TGEKPFVCKECGKAFRDRPGFIRHYIIHSGENPYE-- 344

  Fly   350 CTHCEKTYPSQYTMQQHVKLVHLNLYAKICDVCGKSIRGREALARHMEEHTGGPQAAIKCHLCDS 414
            |..|.|.:..:..:..| :..|.......|..|||:.....||..|...|||  :...:|..|..
Human   345 CFECGKVFKHRSYLMWH-QQTHTGEKPYECSECGKAFCESAALIHHYVIHTG--EKPFECLECGK 406

  Fly   415 MLTTKYGLARHIKMMHTAENLQPMQCEFCLKI---CPSLQAHQHHIKYTHNTARSHQCPMCEKAF 476
            ....:..|.|| :.:||.|  :|..|..|.|.   |.:...|    |..|...:..:|..|.|||
Human   407 AFNHRSYLKRH-QRIHTGE--KPYVCSECGKAFTHCSTFILH----KRAHTGEKPFECKECGKAF 464

  Fly   477 KRPNELKEHMTTHTGEVLYTCPHCPQTFNSNANMHAHRKKVHRKE-------------WEEN--R 526
            ....:|..|.:.||||..|.|..|.:.||..:.:..| :::|..|             |..|  |
Human   465 SNRADLIRHFSIHTGEKPYECMECGKAFNRRSGLTRH-QRIHSGEKPYECIECGKTFCWSTNLIR 528

  Fly   527 HKRLNRSRK 535
            |..::...|
Human   529 HSIIHTGEK 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8388	NP_611075.1	zf-AD	<21..77	CDD:285071	13/68 (19%)
		C2H2 Zn finger	264..281	CDD:275368	5/16 (31%)
		C2H2 Zn finger	289..309	CDD:275368	9/19 (47%)
		C2H2 Zn finger	320..340	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..369	CDD:275368	4/18 (22%)
		C2H2 Zn finger	440..461	CDD:275368	6/23 (26%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		C2H2 Zn finger	497..515	CDD:275368	5/17 (29%)
ZNF805	NP_001018857.2	KRAB	13..73	CDD:214630	18/77 (23%)
		KRAB	13..52	CDD:279668	13/53 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..95		2/23 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..162		10/58 (17%)
		COG5048	192..568	CDD:227381	98/387 (25%)
		C2H2 Zn finger	205..225	CDD:275368	4/19 (21%)
		zf-H2C2_2	218..241	CDD:290200	4/22 (18%)
		C2H2 Zn finger	233..253	CDD:275368	7/25 (28%)
		zf-H2C2_2	245..270	CDD:290200	8/44 (18%)
		C2H2 Zn finger	261..281	CDD:275368	6/19 (32%)
		zf-H2C2_2	273..298	CDD:290200	9/24 (38%)
		C2H2 Zn finger	289..309	CDD:275368	9/19 (47%)
		zf-H2C2_2	305..324	CDD:290200	6/21 (29%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
		zf-C2H2	343..365	CDD:278523	4/24 (17%)
		C2H2 Zn finger	345..365	CDD:275368	4/20 (20%)
		zf-H2C2_2	357..380	CDD:290200	6/23 (26%)
		C2H2 Zn finger	373..393	CDD:275368	7/19 (37%)
		zf-C2H2	399..421	CDD:278523	5/22 (23%)
		C2H2 Zn finger	401..421	CDD:275368	5/20 (25%)
		zf-H2C2_2	413..438	CDD:290200	10/27 (37%)
		C2H2 Zn finger	429..449	CDD:275368	6/23 (26%)
		zf-H2C2_2	445..466	CDD:290200	8/24 (33%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		zf-H2C2_2	469..494	CDD:290200	10/24 (42%)
		C2H2 Zn finger	485..505	CDD:275368	5/20 (25%)
		zf-H2C2_2	498..520	CDD:290200	3/22 (14%)
		C2H2 Zn finger	513..533	CDD:275368	4/19 (21%)
		zf-H2C2_2	525..550	CDD:290200	4/13 (31%)
		C2H2 Zn finger	541..561	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000