DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8388 and Zfp335

DIOPT Version :9

Sequence 1:	NP_611075.1	Gene:	CG8388 / 36763	FlyBaseID:	FBgn0034062	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_030107665.1	Gene:	Zfp335 / 329559	MGIID:	2682313	Length:	1338	Species:	Mus musculus

Alignment Length:	590	Identity:	136/590 - (23%)
Similarity:	212/590 - (35%)	Gaps:	153/590 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 QLLLFHNFYLNVEQAHKALEQTVLKETSPPEVVASALEEHIVKSEHDDSVAAAVKRRRGRPR--- 118
            ::::...|...:.|...:.:.|:|:.........:||           :.|||...:|||.|
Mouse   241 EVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRPAAL-----------AAAAAATGKRGRVRKWG 294

  Fly   119 ---KVAQQDAREELKSVLEQINLNEIKIEFPEADLTIADVLED-QEEQDFLPDDCISKEGAEDP- 178
               |..::|..||               |..:.|:..|..::| :|:.|:.|        |||.
Mouse   295 TSTKTTEEDRPEE---------------EEEDDDIVDAGAIDDLEEDSDYNP--------AEDEP 336

  Fly   179 --EVLEKKPPT----LKRKVSGRSRGRRRVQ-----------LAERPNTSCLPKIQKSQ-EFNDY 225
              ..|..:.||    ..|:..||.|...|::           |....:|...|::|..: ..:..
Mouse   337 RGRQLRLQRPTPSTPRPRRRPGRPRKLPRLETSDLHDGVGQPLVSSQSTQSPPELQDLEAPSSSG 401

  Fly   226 IREHYKV----------QCHICNLPMEDFSEMLAHVRRE---------HKQRGY----------- 260
            :|...||          |....|.......|..|..||.         .|.|.|
Mouse   402 LRALGKVGRGLVESGVSQSDAENAAPSCQDEADAPPRRRGRPSRRFLGKKYRKYYYKSPKPLLRP 466

  Fly   261 AMC--CNRKFLKRGVLVDHLRRHQ--DPETFKCSICGRVMGHRRSLELHMRMHEIKSRGRLYRCE 321
            .:|  |..:||....|..|:..|:  ||:.|:|..|........||:.||..| :.|:.  |:|:
Mouse   467 YLCRICGSRFLSHEDLRFHVNSHEAGDPQLFRCLQCSYRSRRWSSLKEHMFNH-VGSKP--YKCD 528

  Fly   322 QCSKAFYSAVVYE---RHKLTHIPREQWK---------VPCTHCEKTYPSQYTMQQHVKLVHLNL 374
            :||   |::|..:   ||...|....:.:         .||..|.:.||.|..:.||:| .|...
Mouse   529 ECS---YTSVYRKDVIRHAAVHSQDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMK-THSTE 589

  Fly   375 YAKICDVCGKSIRGREALARHMEEHTGGPQAAIKCHLCDSMLTTKYGLARHIKMMHTAENLQPMQ 439
            ...:||.||||.:.|.....|:..|.   ||...               |..|
Mouse   590 KPHMCDKCGKSFKKRYTFKMHLLTHI---QAVAN---------------RRFK------------ 624

  Fly   440 CEFCLKICPSLQAHQHHIKYTHNTARSHQCPMCEKAFKRPNELKEHMTT-HTGEVLYTCPHCPQT 503
            ||||..:|...:|..:| :.:|.:.:..:|..|.....|.:.|..|:.. |||...:.|.:|..:
Mouse   625 CEFCEFVCEDKKALLNH-QLSHVSDKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFS 688

  Fly   504 FNSNANMHAHRKKVHRKEWEE--NRHKRLNRSRKSDTIIAVSVRKTTETRQDGGLVPAEAIATTS 566
            .....|:..|.:..|...:||  .||.....||:....   |:::..|.:|.....|...:   |
Mouse   689 TRHKKNLRLHVRCRHANSFEEWGRRHPEEPPSRRRPFF---SLQQIEELKQQHSTAPGPPL---S 747

  Fly   567 SPRAE 571
            ||..|
Mouse   748 SPGPE 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8388	NP_611075.1	zf-AD	<21..77	CDD:285071	2/19 (11%)
		C2H2 Zn finger	264..281	CDD:275368	5/16 (31%)
		C2H2 Zn finger	289..309	CDD:275368	6/19 (32%)
		C2H2 Zn finger	320..340	CDD:275368	7/22 (32%)
		C2H2 Zn finger	350..369	CDD:275368	7/18 (39%)
		C2H2 Zn finger	440..461	CDD:275368	7/20 (35%)
		C2H2 Zn finger	469..489	CDD:275368	5/20 (25%)
		C2H2 Zn finger	497..515	CDD:275368	4/17 (24%)
Zfp335	XP_030107665.1	zf-H2C2_5	248..268	CDD:372805	4/19 (21%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		C2H2 Zn finger	499..519	CDD:275368	6/19 (32%)
		zf-H2C2_2	511..536	CDD:372612	11/30 (37%)
		zf-H2C2_5	525..548	CDD:372805	8/25 (32%)
		C2H2 Zn finger	527..547	CDD:275368	7/22 (32%)
		C2H2 Zn finger	566..586	CDD:275368	8/20 (40%)
		zf-H2C2_2	578..603	CDD:372612	10/25 (40%)
		C2H2 Zn finger	594..614	CDD:275368	8/19 (42%)
		C2H2 Zn finger	625..645	CDD:275368	7/20 (35%)
		C2H2 Zn finger	653..674	CDD:275368	5/20 (25%)
		C2H2 Zn finger	682..701	CDD:275368	4/18 (22%)
		C2H2 Zn finger	1022..1042	CDD:275368
		SFP1	<1027..1127	CDD:227516
		C2H2 Zn finger	1050..1070	CDD:275368
		zf-H2C2_5	1076..1100	CDD:372805
		C2H2 Zn finger	1078..1098	CDD:275368
		zf-H2C2_2	1090..1115	CDD:372612
		C2H2 Zn finger	1106..1127	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834458
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030