DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8388 and CG11695

DIOPT Version :9

Sequence 1:	NP_611075.1	Gene:	CG8388 / 36763	FlyBaseID:	FBgn0034062	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_572732.1	Gene:	CG11695 / 32106	FlyBaseID:	FBgn0030316	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	160/571 - (28%)
Similarity:	250/571 - (43%)	Gaps:	88/571 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPCFLCTQTVDDAAGNIEFASEEADS------LGLRCIIEKHFWL-QIPDSKRAGYVCGPCWEQL 58
            |.|.||   :|||..::....:: ||      ..|..:||||..| .:|:...:..:|..||:||
  Fly     1 MICRLC---LDDAEHSVPIFDQD-DSGDQPVPSNLAELIEKHLQLVLLPNDGVSKSLCTQCWQQL 61

  Fly    59 LLFHNFYLNVEQAHKALEQTVLKETSPPEVVASALEEHIVKSEHDDSVAAAVKRRRGRPRKVAQQ 123
            ..|..|...|.:....|:|..::..|..| .|....:.:.:.|.|.|.|||...........|..
  Fly    62 ADFEQFCAMVMKKQLGLQQLKMEPFSEDE-DADTKAQILCEPEIDVSPAAADNEECNEIDGDASS 125

  Fly   124 DAREELKSVLEQINLNEIKIEFP-----------EADLTIA---------DVLEDQEEQDFLPDD 168
            ::|   .|.:...:|.|:::..|           .|..|.|         ...|..|::|
  Fly   126 NSR---SSSIRTTSLREMRLPSPIRRRMRLPRAVTAPKTQAVKAKARTKTHKAEADEDED----- 182

  Fly   169 CISKEGAEDPEVLEKKPPTLKRKVSGRSRGRRRVQLAERPNTSCLPKIQKSQEFNDYIREHYKVQ 233
               .||..|||                ||.                  ..|:|.:.||..|.:::
  Fly   183 ---AEGEGDPE----------------SRS------------------SNSREMDSYIALHGRLE 210

  Fly   234 CHIC--NLPMEDFSEMLAHVRREHKQRGYAMCCNRKFLKRGVLVDHLRRHQDPETFKCSICGRVM 296
            |.||  :....:|:||..|.|..|:..||.:||.|::.||.:.||||..|.||..|:|.||.:.:
  Fly   211 CCICGGDEQFPNFAEMKRHFRNHHQSLGYVVCCQRRYKKRALYVDHLHMHNDPNYFRCKICSKQL 275

  Fly   297 GHRRSLELHM-RMHEIKSRGRLYRCEQCSKAFYSAVVYERHKLTHIPREQWKVPCTHCEKTYPSQ 360
            ..|.|.::|| |.|..|. ...:.|:||||.|....:...|...|  :::....|.||::::.:.
  Fly   276 VSRISYDVHMLRFHPNKD-DLSFACDQCSKRFSKQFLLTIHSRVH--QQERNEQCKHCDRSFRTA 337

  Fly   361 YTMQQHVKLVHLNLYAK-ICDVCGKSIRGREALARHMEE-HTGGPQ-AAIKCHLCDSMLTTKYGL 422
            ..::.|::..|...:.. |||.||...:.::.|..|... |..|.| ..::|..|...|:.:..|
  Fly   338 VDLRLHMRRTHDPAFVPFICDSCGAKFKTKQNLLVHKRTVHREGSQLPEVQCQECQVWLSDENSL 402

  Fly   423 ARHIKMMHTAENLQPMQCEFCLKICPSLQAHQHHIKYTHNTARSHQCPMCEKAFKRPNELKEHMT 487
            .:|:.|...|.:|:..:||.|.....|......||:| |:....|:|..|.|.||....|:||..
  Fly   403 RKHMYMHLDAASLRQWKCEQCGLEKGSRAKLAAHIRY-HHPKEYHKCTHCAKEFKSSRSLEEHTA 466

  Fly   488 THTGEVLYTCPHCPQTFNSNANMHAHRKKVHRKEWEE-NRHKRLNRSRKSD 537
            ||||:.||.|..|.:||.::.|||.||:::|..:... .:.|::..|::.|
  Fly   467 THTGQDLYECAFCERTFKNSGNMHKHRRQMHAAQVAALQQQKKVPPSKRKD 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8388	NP_611075.1	zf-AD	<21..77	CDD:285071	18/62 (29%)
		C2H2 Zn finger	264..281	CDD:275368	8/16 (50%)
		C2H2 Zn finger	289..309	CDD:275368	8/20 (40%)
		C2H2 Zn finger	320..340	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..369	CDD:275368	4/18 (22%)
		C2H2 Zn finger	440..461	CDD:275368	7/20 (35%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..515	CDD:275368	8/17 (47%)
CG11695	NP_572732.1	zf-AD	2..81	CDD:285071	24/82 (29%)
		C2H2 Zn finger	268..289	CDD:275368	8/20 (40%)
		C2H2 Zn finger	299..319	CDD:275368	7/19 (37%)
		C2H2 Zn finger	327..348	CDD:275368	4/20 (20%)
		C2H2 Zn finger	357..376	CDD:275368	6/18 (33%)
		C2H2 Zn finger	389..409	CDD:275368	5/19 (26%)
		C2H2 Zn finger	420..440	CDD:275368	7/20 (35%)
		C2H2 Zn finger	448..468	CDD:275368	8/19 (42%)
		C2H2 Zn finger	476..494	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134721
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910