DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8388 and Traf6

DIOPT Version :9

Sequence 1:	NP_611075.1	Gene:	CG8388 / 36763	FlyBaseID:	FBgn0034062	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001101224.1	Gene:	Traf6 / 311245	RGDID:	1306853	Length:	530	Species:	Rattus norvegicus

Alignment Length:	256	Identity:	61/256 - (23%)
Similarity:	98/256 - (38%)	Gaps:	62/256 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 NTSCLPKIQ-KSQEFNDYIREHYKVQCHICNLPMEDFSEMLAHVRREHKQR--GYAMC------- 263
            ::|.:.:|| ...||:..:...|  :|.||.:.:           ||..|.  |:..|
  Rat    46 SSSFMEEIQGYDVEFDPPLESKY--ECPICLMAL-----------REAVQTPCGHRFCKACITKS 97

  Fly   264 -------C---NRKFLKRGVLVDHLRRHQDPE-TFKCSICGRVMGHRRSLEL-HMRMHEIKSRGR 316
                   |   |...|:..:..|:..:.:... |.||...|.|    :.:|| |:..|::.....
  Rat    98 IRDAGHKCPVDNEILLENQLFPDNFAKREILSLTVKCPNKGCV----QKMELRHLEDHQVHCEFA 158

  Fly   317 LYRCEQCSKAFYSAVVYERHKLTHIPREQWKVPCTHC--EKTYPSQYTMQQHVKLVHLNLYAKIC 379
            |..|.||.: |:......:|.:...||.|  |.|.:|  ...|..:....|...|.::     ||
  Rat   159 LVICPQCQR-FFQKCQINKHIIEDCPRRQ--VSCVNCAVPMPYEEKEIHDQSCPLANI-----IC 215

  Fly   380 DVCGKSIRGREALARHMEEHTGGPQAAIKCHL----CDSMLTTKYGLARHIKMMHTAENLQ 436
            :.|| :|..||.:..|.:  ...|.|.:.|..    |...:...: ||||::     ||.|
  Rat   216 EYCG-TILIREQMPNHYD--LDCPTAPVPCTFSVFGCHEKMQRNH-LARHLQ-----ENTQ 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8388	NP_611075.1	zf-AD	<21..77	CDD:285071
		C2H2 Zn finger	264..281	CDD:275368	4/19 (21%)
		C2H2 Zn finger	289..309	CDD:275368	6/20 (30%)
		C2H2 Zn finger	320..340	CDD:275368	5/19 (26%)
		C2H2 Zn finger	350..369	CDD:275368	4/20 (20%)
		C2H2 Zn finger	440..461	CDD:275368
		C2H2 Zn finger	469..489	CDD:275368
		C2H2 Zn finger	497..515	CDD:275368
Traf6	NP_001101224.1	Interaction with TAX1BP1. /evidence=ECO:0000250	1..362		61/256 (24%)
		mRING-HC-C3HC3D_TRAF6	67..124	CDD:319557	13/69 (19%)
		PLN03086	<132..219	CDD:178635	25/98 (26%)
		TRAF6_Z2	157..183	CDD:407885	6/26 (23%)
		zf-TRAF	204..261	CDD:280357	16/65 (25%)
		DUF460	<273..>352	CDD:421465
		MATH_TRAF6	359..508	CDD:239745
		Interaction with TANK. /evidence=ECO:0000250\|UniProtKB:Q9Y4K3	363..530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000