DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8388 and Zfp646

DIOPT Version :9

Sequence 1:	NP_611075.1	Gene:	CG8388 / 36763	FlyBaseID:	FBgn0034062	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_766337.2	Gene:	Zfp646 / 233905	MGIID:	3665412	Length:	1788	Species:	Mus musculus

Alignment Length:	438	Identity:	93/438 - (21%)
Similarity:	160/438 - (36%)	Gaps:	117/438 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 PEADLTIADVLEDQEEQDFLPDDCISKEGAEDPEVLE-KKPPTLKRKVSGRSRGRRRVQLAERPN 209
            |.|.....|:||.|:          |.||.:..:..| |:.||.......||.|    ||::...
Mouse   292 PRAFRLPRDLLEHQQ----------SHEGLKQEQPWEDKEMPTTNGHADERSWG----QLSKTGM 342

  Fly   210 TSCLPKIQKSQEFNDYIREHYKVQCHICNLPMEDFSEMLAHVRREHKQRGYAMC--CNRKFLKRG 272
            .:...::..|.:..|...|.|:..|                            |  |.|.:...|
Mouse   343 LNGSGELSSSGQLEDGGSEEYRPFC----------------------------CGDCGRTYRHAG 379

  Fly   273 VLVDHLRRHQDPETFKCSICGRVMGHRRSLELHMRMHEIKSRG---------------------- 315
            .|::|.:.|| ...:.||||.:.:.:..:|:.|:|.|....:|
Mouse   380 SLINHRKSHQ-TGIYPCSICSKQLFNAAALKNHIRAHHRPRQGAGEGGQSSVSSTALTSAENTPK 443

  Fly   316 -----------RLYRCEQCSKAFYSAVVYERHKLTHIPREQWKVPCTHCEKTYPSQYTMQQHVKL 369
                       |.|:|.:|.:|:........|:.:|...|   ..|:.|.:.||:...::.||:
Mouse   444 VDEVPTASLDHRPYKCNECGRAYRHRGSLVNHRHSHRTGE---YQCSLCPRKYPNLMALRNHVR- 504

  Fly   370 VHLNLYAKICDVCGKSIRGREALARHMEEHTGGPQAAI---KCHLC--DSMLTTKYGLARHIKMM 429
            ||.....:..|   ....|..:..:..:....|.:||.   :.|.|  :...|:...:
Mouse   505 VHCKATRRSTD---PGTEGSPSPVKKEQHDPVGMEAAFHGDEEHACKREEEATSNPSM------- 559

  Fly   430 HTAENLQPMQCEFCLKICPSLQAHQHHIKYTH------------NTARSHQCPMCEKAFKRPNEL 482
              |:...|..|..|..:...|::.:|| ..||            :..|:..|..|.|:::....|
Mouse   560 --ADRTVPQVCSICGMLFEDLKSLEHH-SVTHREGEKSRTDSTVSPTRTFACQDCGKSYRHSGSL 621

  Fly   483 KEHMTTH-TGEVLYTCPHCPQTFNSNANMHAHRKKVHRKEWEENRHKR 529
            ..|..|| ||:  ::|..|.:.|::.|.|.:|.:: |.::|...|.|:
Mouse   622 INHRQTHQTGD--FSCGACAKHFHTMAAMKSHLRR-HSRQWNRRRQKQ 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8388	NP_611075.1	zf-AD	<21..77	CDD:285071
		C2H2 Zn finger	264..281	CDD:275368	5/16 (31%)
		C2H2 Zn finger	289..309	CDD:275368	7/19 (37%)
		C2H2 Zn finger	320..340	CDD:275368	4/19 (21%)
		C2H2 Zn finger	350..369	CDD:275368	6/18 (33%)
		C2H2 Zn finger	440..461	CDD:275368	5/20 (25%)
		C2H2 Zn finger	469..489	CDD:275368	5/19 (26%)
		C2H2 Zn finger	497..515	CDD:275368	6/17 (35%)
Zfp646	NP_766337.2	C2H2 Zn finger	10..31	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..48
		C2H2 Zn finger	69..89	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..196
		C2H2 Zn finger	233..253	CDD:275368
		C2H2 Zn finger	260..280	CDD:275368
		C2H2 Zn finger	288..308	CDD:275368	6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..360		14/67 (21%)
		C2H2 Zn finger	368..388	CDD:275368	6/19 (32%)
		C2H2 Zn finger	395..415	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..449		1/32 (3%)
		C2H2 Zn finger	459..479	CDD:275368	4/19 (21%)
		C2H2 Zn finger	486..506	CDD:275368	6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..531		2/24 (8%)
		C2H2 Zn finger	568..588	CDD:275368	5/20 (25%)
		C2H2 Zn finger	608..628	CDD:275368	5/19 (26%)
		C2H2 Zn finger	635..655	CDD:275368	6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..712		5/17 (29%)
		C2H2 Zn finger	808..828	CDD:275368
		C2H2 Zn finger	835..855	CDD:275368
		C2H2 Zn finger	868..886	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	889..916
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	956..976
		C2H2 Zn finger	1037..1057	CDD:275368
		C2H2 Zn finger	1064..1084	CDD:275368
		C2H2 Zn finger	1172..1192	CDD:275368
		C2H2 Zn finger	1199..1219	CDD:275368
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1268..1285	CDD:275368
		C2H2 Zn finger	1295..1315	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1351..1386
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1398..1439
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1455..1489
		C2H2 Zn finger	1500..1518	CDD:275368
		C2H2 Zn finger	1526..1544	CDD:275368
		C2H2 Zn finger	1552..1572	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1579..1629
		C2H2 Zn finger	1642..1662	CDD:275368
		C2H2 Zn finger	1669..1689	CDD:275368
		zf-H2C2_2	1681..1706	CDD:372612
		C2H2 Zn finger	1697..1717	CDD:275368
		C2H2 Zn finger	1726..1746	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1744..1788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100