DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8388 and Zfy1

DIOPT Version :9

Sequence 1:	NP_611075.1	Gene:	CG8388 / 36763	FlyBaseID:	FBgn0034062	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_033596.3	Gene:	Zfy1 / 22767	MGIID:	99212	Length:	782	Species:	Mus musculus

Alignment Length:	640	Identity:	153/640 - (23%)
Similarity:	233/640 - (36%)	Gaps:	203/640 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TQTVDDAAGNIEFASEEADSLGLRCIIEKHFWLQIPDSKRAGYVCGPCWEQLLLFHNFYLNVE-- 69
            ::.|.|::|   ...|:.|:..:.|  |.:..:.:.:..:|                   ::|
Mouse   176 SEAVLDSSG---MPLEQQDNDKINC--EDYLMMSLDEPSKA-------------------DLEGS 216

  Fly    70 -----QAHKALEQTVLKETSPPEVVA-------SALEE-----HIVKSE---------HDDSVAA 108
                 .|....:.:.|.|.| |||:.       |.::|     |.|:||         .|.|.:.
Mouse   217 SEVTMNAESGTDSSKLDEAS-PEVIKVCILKADSEVDELGETIHAVESETKNGNEAEVTDQSTSI 280

  Fly   109 AVKRRRGRPR---KVAQQDAREELKSVLEQINLNEIKIEFPEADLTIADVLEDQEEQD------- 163
            .|      ||   .::..|:::|.:.       .|:.:...:|..|.||..|.:::.|
Mouse   281 RV------PRVNIYMSASDSQKEEED-------TEVIVGDEDAGGTAADTPEHEQQMDVSEIKAA 332

  Fly   164 FLP-------DDCISKEGAEDPEVLEKKPPTLKRKVSGRSRGRRRVQLAERPNTSCLPKIQKSQE 221
            |||       |:  :.:..||..|...  ..|.:..||   |..||           || |||::
Mouse   333 FLPIAWTAAYDN--NSDEIEDQNVTAS--ALLNQDESG---GLDRV-----------PK-QKSKK 378

  Fly   222 FNDYIREHYKVQCHICNLPMEDFSEMLAHVRREHKQ--------------RGY-AMCCNRKFLKR 271
                                        ..|.|.||              |.| .|.|.:||..:
Mouse   379 ----------------------------KKRPESKQYQSAIFVAPDGQTLRVYPCMFCGKKFKTK 415

  Fly   272 GVLVDHLRRHQDPE-----TFKCSICGRVMGHRRSLELHMRMHE--IKSRGRLYRCEQCSKAFYS 329
            ..|..|.:.|  ||     .:.|:.|......:.||..||..|:  ||:. :...|:.|.|....
Mouse   416 RFLKRHTKNH--PEYLANKKYHCTECDYSTNKKISLHNHMESHKLTIKTE-KTTECDDCRKNLSH 477

  Fly   330 AVVYERHKLTHIPREQWKV-PCTHCEKTYPSQYTMQQHVKLVHLNLYAKICDVCGKSIRGREALA 393
            |.....||..|..:...|. .|..|:.....|..:..|:.:||...:..||..|||..|...||.
Mouse   478 AGTLCTHKTMHTEKGVNKTCKCKFCDYETAEQTLLNHHLLVVHRKKFPHICGECGKGFRHPSALK 542

  Fly   394 RHMEEHTGGPQAAIKCHLCDSMLTTKYGLARHIKMMHTAENLQPMQCEFC-LKICPSLQAHQH-- 455
            :|:..|||  :...:|..|:........|..|||..|:.|  .|::|..| |....:.:|.||
Mouse   543 KHIRVHTG--EKPYECQYCEYKSADSSNLKTHIKSKHSKE--IPLKCGICLLTFSDNKEAQQHAV 603

  Fly   456 -------------------------HIKYTHNTARSHQCPMCEKAFKRPNELKEHMTTHTGEVLY 495
                                     ||...|..|..|:|.||.|.|.||:|||:|:.||..:.::
Mouse   604 LHQESRTHQCSHCNHKSSNSSDLKRHIISVHTKAYPHKCDMCSKGFHRPSELKKHVATHKSKKMH 668

  Fly   496 TCPHC----PQTF-NSNANMHAHRKKVH------RKEWEE----NRHKRLNRSRK 535
            .|.||    |..| .|:..:.||.|.|.      :||:::    ..|.:.:.|||
Mouse   669 QCRHCDFNSPDPFLLSHHILSAHTKNVPFKCKRCKKEFQQQCELQTHMKTHSSRK 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8388	NP_611075.1	zf-AD	<21..77	CDD:285071	7/62 (11%)
		C2H2 Zn finger	264..281	CDD:275368	5/16 (31%)
		C2H2 Zn finger	289..309	CDD:275368	6/19 (32%)
		C2H2 Zn finger	320..340	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..369	CDD:275368	4/18 (22%)
		C2H2 Zn finger	440..461	CDD:275368	8/48 (17%)
		C2H2 Zn finger	469..489	CDD:275368	11/19 (58%)
		C2H2 Zn finger	497..515	CDD:275368	8/22 (36%)
Zfy1	NP_033596.3	Zfx_Zfy_act	68..388	CDD:282547	58/296 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..233		3/40 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..386		13/68 (19%)
		Nuclear localization signal. /evidence=ECO:0000255	372..382		5/38 (13%)
		C2H2 Zn finger	405..425	CDD:275370	6/19 (32%)
		C2H2 Zn finger	436..456	CDD:275370	6/19 (32%)
		C2H2 Zn finger	468..488	CDD:275368	6/19 (32%)
		C2H2 Zn finger	499..520	CDD:275368	4/20 (20%)
		COG5048	<513..687	CDD:227381	54/177 (31%)
		zf-C2H2	526..548	CDD:278523	9/21 (43%)
		C2H2 Zn finger	528..548	CDD:275368	8/19 (42%)
		zf-H2C2_2	540..562	CDD:290200	8/23 (35%)
		C2H2 Zn finger	556..577	CDD:275368	6/20 (30%)
		C2H2 Zn finger	585..605	CDD:275368	6/19 (32%)
		C2H2 Zn finger	613..634	CDD:275368	2/20 (10%)
		C2H2 Zn finger	642..691	CDD:275368	19/48 (40%)
		C2H2 Zn finger	699..719	CDD:275368	3/19 (16%)
		zf-H2C2_2	711..735	CDD:290200	4/13 (31%)
		C2H2 Zn finger	727..748	CDD:275368
		C2H2 Zn finger	756..776	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000