DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8388 and ZNF513

DIOPT Version :9

Sequence 1:NP_611075.1 Gene:CG8388 / 36763 FlyBaseID:FBgn0034062 Length:572 Species:Drosophila melanogaster
Sequence 2:NP_653232.3 Gene:ZNF513 / 130557 HGNCID:26498 Length:541 Species:Homo sapiens


Alignment Length:556 Identity:109/556 - (19%)
Similarity:170/556 - (30%) Gaps:212/556 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   111 KRRRGRPR-------KVAQQDAREELKS--VLEQINLNEIKIEFPEADLTIADVLEDQEEQDFLP 166
            :|::..|:       ||..:|:.:|...  |||...|....:||.|.        |::||.|...
Human     3 RRKQSHPQPVKCEGVKVDTEDSLDEGPGALVLESDLLLGQDLEFEEE--------EEEEEGDGNS 59

  Fly   167 DDCISKEGAEDPEVLEKKPP----------------TLKRKVSGRSRGRRRVQLAERPNTSCL-- 213
            |..:..|...:.:.|..:|.                :.:.:|...:||....: .|||..:|.  
Human    60 DQLMGFERDSEGDSLGARPGLPYGLSDDESGGGRALSAESEVEEPARGPGEAR-GERPGPACQLC 123

  Fly   214 ----------------------PKIQKSQEFNDYIREHYKVQCHICNLPMEDFSEMLAHVRREHK 256
                                  |::..|              |.:|..    .|...:|::|   
Human   124 GGPTGEGPCCGAGGPGGGPLLPPRLLYS--------------CRLCTF----VSHYSSHLKR--- 167

  Fly   257 QRGYAMCCNRKFLKRGVLVDHLRRHQDPETFKCSICGRVMGHRRSLELHMRMHEIKSRGRLYRCE 321
                                |::.|...:.|:|..|........:|..|.|.|   :..:.|||.
Human   168 --------------------HMQTHSGEKPFRCGRCPYASAQLVNLTRHTRTH---TGEKPYRCP 209

  Fly   322 QCSKAFYSAVVYERHKLTHI--PREQWKVPCTHC-------EKTYPSQYTMQQ---------HVK 368
            .|..|..|.....||:.||.  |..    ||..|       ....|...|.|:         .:.
Human   210 HCPFACSSLGNLRRHQRTHAGPPTP----PCPTCGFRCCTPRPARPPSPTEQEGAVPRRPEDALL 270

  Fly   369 LVHLNLYAK-------------------ICD---------------------------------V 381
            |..|:|:..                   :|.                                 :
Human   271 LPDLSLHVPPGGASFLPDCGQLRGEGEGLCGTGSEPLPELLFPWTCRGCGQELEEGEGSRLGAAM 335

  Fly   382 CGKSIRGREA-----------------------------LARHMEEHTGGPQAAIKCHLCDSMLT 417
            ||:.:||...                             |||||:.|:|  :...:|..|.....
Human   336 CGRCMRGEAGGGASGGPQGPSDKGFACSLCPFATHYPNHLARHMKTHSG--EKPFRCARCPYASA 398

  Fly   418 TKYGLARHIKMMHTAENLQPMQCEFCLKICPSLQAHQHHIKYTHNTARSHQCPMCEKAFKRPNEL 482
            ....|.|| :.:||.|  :|.:|..|...|.:|...:.|.: .|:..:..:|.:|..:..:...|
Human   399 HLDNLKRH-QRVHTGE--KPYKCPLCPYACGNLANLKRHGR-IHSGDKPFRCSLCNYSCNQSMNL 459

  Fly   483 KEHMTTHTGEVLYTCPHCPQTFNSNANMHAHRKKVH 518
            |.||..||||..:.|..|..|.....|...| :|||
Human   460 KRHMLRHTGEKPFRCATCAYTTGHWDNYKRH-QKVH 494

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8388NP_611075.1 zf-AD <21..77 CDD:285071
C2H2 Zn finger 264..281 CDD:275368 1/16 (6%)
C2H2 Zn finger 289..309 CDD:275368 5/19 (26%)
C2H2 Zn finger 320..340 CDD:275368 6/19 (32%)
C2H2 Zn finger 350..369 CDD:275368 5/34 (15%)
C2H2 Zn finger 440..461 CDD:275368 5/20 (25%)
C2H2 Zn finger 469..489 CDD:275368 6/19 (32%)
C2H2 Zn finger 497..515 CDD:275368 5/17 (29%)
ZNF513NP_653232.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..118 27/123 (22%)
C2H2 Zn finger 152..172 CDD:275368 6/46 (13%)
COG5048 176..>228 CDD:227381 15/54 (28%)
C2H2 Zn finger 180..200 CDD:275368 5/19 (26%)
zf-H2C2_2 192..217 CDD:316026 9/27 (33%)
C2H2 Zn finger 208..228 CDD:275368 6/19 (32%)
C2H2 Zn finger 362..382 CDD:275368 5/19 (26%)
COG5048 <372..>450 CDD:227381 23/83 (28%)
C2H2 Zn finger 390..410 CDD:275368 5/20 (25%)
COG5048 414..>487 CDD:227381 20/73 (27%)
C2H2 Zn finger 418..438 CDD:275368 5/20 (25%)
C2H2 Zn finger 446..466 CDD:275368 6/19 (32%)
C2H2 Zn finger 474..493 CDD:275368 5/19 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 492..541 3/3 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24403
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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