DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8388 and PRDM5

DIOPT Version :9

Sequence 1:	NP_611075.1	Gene:	CG8388 / 36763	FlyBaseID:	FBgn0034062	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001366033.1	Gene:	PRDM5 / 11107	HGNCID:	9349	Length:	641	Species:	Homo sapiens

Alignment Length:	580	Identity:	135/580 - (23%)
Similarity:	222/580 - (38%)	Gaps:	141/580 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 FYLNVEQAHKALEQTVLKETSPPEVVASALEEHIVKSEHDDSVAAAVKRRRGRPRKVAQQDAREE 128
            |||.||..          ||. .|::...|:..:...|.:..:...:|...      .:...|:.
Human   106 FYLAVEDI----------ETD-TELLIGYLDSDMEAEEEEQQIMTVIKEGE------VENSRRQS 153

  Fly   129 LKSVLEQINLNEIKIEFPEADLTIADVLEDQEEQDFLPDDCISKEGAEDPEVLEKKPPTLKRKVS 193
            .....:::...|             |....|.|..|..:|.:    ||..:.|.:| ||.:::..
Human   154 TAGRKDRLGCKE-------------DYACPQCESSFTSEDIL----AEHLQTLHQK-PTEEKEFK 200

  Fly   194 GRSRGRR--RVQLAERPNTSCLPKIQKSQEFNDYIREHYKVQCHICNLPMEDFSEMLAHVRREHK 256
            .::.|::  ..|..:|....|..|....:....:       ||.:||   ..||...:..:.:..
Human   201 CKNCGKKFPVKQALQRHVLQCTAKSSLKESSRSF-------QCSVCN---SSFSSASSFEQHQET 255

  Fly   257 QRGYA--MC----CNRKFLKRGVLVDHLRRHQ------DP-ETFKCSICGRVMGHRRSLELHMRM 308
            .||.|  :|    |.::...:    |.|:|||      || :...||:|.:......||:.|.::
Human   256 CRGDARFVCKADSCGKRLKSK----DALKRHQENVHTGDPKKKLICSVCNKKCSSASSLQEHRKI 316

  Fly   309 HEIKSRGRLYRCEQCSKAFYSAVVYERHKLTHIPR---------EQWKVPCTHCEKTYPSQYTMQ 364
            |||      :.|::|.|.|.||...:||.:||...         |:....|..|.|::.....:.
Human   317 HEI------FDCQECMKKFISANQLKRHMITHSDMRLSPLIFLIEKRPYNCEICNKSFKRLDQVG 375

  Fly   365 QHVKLVHLNLYAKICDVCGKSIRGREALARHMEEHT--------------------------GGP 403
            .| |::|.......|.:|||....|.....|.:.|:                          ...
Human   376 AH-KVIHSEDKPYKCKLCGKGFAHRNVYKNHKKTHSEERPFQCEECKALFRTPFSLQRHLLIHNS 439

  Fly   404 QAAIKCHLCDSMLTTKYGLARHIKMMHTAENLQPMQCEFCLK--ICPS-LQAHQHHIKYTHNTAR 465
            :...|||.||:....|..|..|::::|  |..:..:||.|.|  :.|| |::|    |.||...:
Human   440 ERTFKCHHCDATFKRKDTLNVHVQVVH--ERHKKYRCELCNKAFVTPSVLRSH----KKTHTGEK 498

  Fly   466 SHQCPMCEKAFKRPNELKEHMTTHTGEVLYTCPHCPQTFNSNANMHAH-----RKKVHR-----K 520
            ...||.|.:.|.....|:.|:.:||||..|.||:|.:.|:.|..:..|     |:|.::     |
Human   499 EKICPYCGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHIRTHTREKPYKCSECSK 563

  Fly   521 EWEENR----HKRLNRSRK---SDTI-IAVSVRKTTETRQDGGLVPAEAIATTSSPRAEC 572
            .:.:.|    |||.:...|   .|.. :|.|::|.        |:..:.....:.|.|||
Human   564 AFSQKRGLDEHKRTHTGEKPFQCDVCDLAFSLKKM--------LIRHKMTHNPNRPLAEC 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8388	NP_611075.1	zf-AD	<21..77	CDD:285071	5/12 (42%)
		C2H2 Zn finger	264..281	CDD:275368	3/16 (19%)
		C2H2 Zn finger	289..309	CDD:275368	6/19 (32%)
		C2H2 Zn finger	320..340	CDD:275368	8/19 (42%)
		C2H2 Zn finger	350..369	CDD:275368	4/18 (22%)
		C2H2 Zn finger	440..461	CDD:275368	9/23 (39%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		C2H2 Zn finger	497..515	CDD:275368	6/22 (27%)
PRDM5	NP_001366033.1	PR-SET_PRDM5	2..128	CDD:380967	9/32 (28%)
		COG5048	<145..338	CDD:227381	51/236 (22%)
		C2H2 Zn finger	169..190	CDD:275368	6/24 (25%)
		C2H2 Zn finger	201..221	CDD:275368	3/19 (16%)
		C2H2 Zn finger	236..256	CDD:275368	5/22 (23%)
		COG5048	262..631	CDD:227381	97/379 (26%)
		C2H2 Zn finger	264..287	CDD:275368	7/26 (27%)
		C2H2 Zn finger	297..317	CDD:275368	6/19 (32%)
		C2H2 Zn finger	322..342	CDD:275368	8/19 (42%)
		C2H2 Zn finger	361..381	CDD:275368	5/20 (25%)
		C2H2 Zn finger	389..409	CDD:275368	6/19 (32%)
		C2H2 Zn finger	417..437	CDD:275368	0/19 (0%)
		C2H2 Zn finger	445..462	CDD:275368	6/16 (38%)
		C2H2 Zn finger	474..494	CDD:275368	9/23 (39%)
		C2H2 Zn finger	502..522	CDD:275368	6/19 (32%)
		C2H2 Zn finger	530..550	CDD:275368	6/19 (32%)
		C2H2 Zn finger	558..578	CDD:275368	5/19 (26%)
		C2H2 Zn finger	586..606	CDD:275368	5/27 (19%)
		C2H2 Zn finger	615..636	CDD:275368	1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910