DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8388 and zfp64

DIOPT Version :9

Sequence 1:	NP_611075.1	Gene:	CG8388 / 36763	FlyBaseID:	FBgn0034062	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001373446.1	Gene:	zfp64 / 100003733	ZFINID:	ZDB-GENE-031118-80	Length:	642	Species:	Danio rerio

Alignment Length:	351	Identity:	82/351 - (23%)
Similarity:	137/351 - (39%)	Gaps:	56/351 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 VSGRSRGRRRVQLAERPNTSCLPKIQKS-----QEFNDYIREHYKVQCHICNLPMEDFSEMLAHV 251
            :|.|:.|      |.....:|:.|::|:     :..:..::.....:.|||......|.
Zfish    51 ISVRNAG------ASESLQTCVSKVKKTLTKAQKNPSKKLKPALTQKRHICTFSGCTFK------ 103

  Fly   252 RREHKQRGYAMCCNRKFLKRGVLVDHLRRHQDPETFKCSICGRVMGHRRSLELHMRMHEIKSRGR 316
                .|.|      :|.::|     |:..|.....|:|.:|.:....|..|.||.|:|   :..:
Zfish   104 ----TQYG------QKDMER-----HILTHTGERPFECELCHKRFSRRDKLNLHSRLH---TGEK 150

  Fly   317 LYRCEQCSKAFYSAVVYERHKLTHIPREQWKVPCTHCEKTYPSQYTMQQHVKLVHLNLYAK---- 377
            .::|:.|:.|...:...::|...|.....:|  |..|  .|.|:.:.|   ..|||..:..
Zfish   151 PHKCKYCTYAAADSSSLKKHLRIHYDERPFK--CQIC--PYASRNSSQ---LTVHLRSHTGDAPF 208

  Fly   378 ICDVCGKSIRGREALARHMEEHTGGPQAAIKCHLCDSMLTTKYGLARHIKMMHTAENLQPMQCEF 442
            .|:.|....:....|.||...|:|  :...||.|||.....|..|..|:.:.|:|.:  ...|..
Zfish   209 QCNQCDAKFKINSDLKRHSRVHSG--EKPYKCDLCDYRCAMKANLKSHVHLKHSASD--SFHCSK 269

  Fly   443 CLKICPSLQAHQHHIKYTHNTARSHQCPMCEKAFKRPNELKEHMTTHTGEVLYTCPHCPQTFNSN 507
            |...|.:..|.:||.: .|..|:..||..|..:......||.|...|:.|..:.|..|.......
Zfish   270 CDFQCSTKAALRHHSR-QHQPAQPLQCSECSYSCSSKGALKIHERVHSDERPFKCDLCSFASKQR 333

  Fly   508 ANMHAHRKKVHRKEWEENRHKRLNRS 533
            :|:..|.:|.|     .::..||::|
Zfish   334 SNLLIHTRKCH-----ADKPDRLSKS 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8388	NP_611075.1	zf-AD	<21..77	CDD:285071
		C2H2 Zn finger	264..281	CDD:275368	3/16 (19%)
		C2H2 Zn finger	289..309	CDD:275368	7/19 (37%)
		C2H2 Zn finger	320..340	CDD:275368	4/19 (21%)
		C2H2 Zn finger	350..369	CDD:275368	5/18 (28%)
		C2H2 Zn finger	440..461	CDD:275368	6/20 (30%)
		C2H2 Zn finger	469..489	CDD:275368	5/19 (26%)
		C2H2 Zn finger	497..515	CDD:275368	4/17 (24%)
zfp64	NP_001373446.1	C2H2 Zn finger	95..118	CDD:275368	7/43 (16%)
		zf-H2C2_2	110..135	CDD:404364	6/29 (21%)
		C2H2 Zn finger	126..146	CDD:275368	7/19 (37%)
		zf-H2C2_2	139..162	CDD:404364	8/25 (32%)
		C2H2 Zn finger	154..174	CDD:275368	4/19 (21%)
		SFP1	<176..260	CDD:227516	24/92 (26%)
		C2H2 Zn finger	182..202	CDD:275368	8/24 (33%)
		C2H2 Zn finger	210..230	CDD:275368	5/19 (26%)
		zf-H2C2_2	222..246	CDD:404364	10/25 (40%)
		C2H2 Zn finger	238..257	CDD:275368	7/18 (39%)
		C2H2 Zn finger	323..341	CDD:275368	4/17 (24%)
		C2H2 Zn finger	384..404	CDD:275368
		SP1-4_N	<408..>605	CDD:425404
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577399
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.030