DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8370 and tmem131l

DIOPT Version :9

Sequence 1:	NP_001286471.1	Gene:	CG8370 / 36761	FlyBaseID:	FBgn0034060	Length:	1567	Species:	Drosophila melanogaster
Sequence 2:	XP_693816.8	Gene:	tmem131l / 565444	ZFINID:	ZDB-GENE-030131-6110	Length:	1501	Species:	Danio rerio

Alignment Length:	1744	Identity:	336/1744 - (19%)
Similarity:	562/1744 - (32%)	Gaps:	574/1744 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 PSRLDFGTWSVGQARSQTVTLFNQHSNRTLQLNAVAGPSPAFYSSFLGTREVPPQGNTTFNVVFL 122
            |..||||...||..|::||.:.|......:.|.:|...|..|:......|.:||:|.|:|.::||
Zfish    89 PPTLDFGPQPVGLPRAETVYIHNPSPELPVSLLSVFTSSRHFHMPSFHRRVIPPRGRTSFKIIFL 153

  Fly   123 PRQLGAIAADLLIHTS---------FGQAELAVQGEGSECPYRLKPLVGIKAPMNATLTPEIHMY 178
            |...|.....|.|:||         ||   :.|.||..:..:|...::         :.|.|...
Zfish   154 PTVEGNEEISLFINTSTHGLLSYQVFG---VGVHGESVKDAHRKDSVL---------IFPHIQSI 206

  Fly   179 NPHERPLQILEIYSSGGEFQLELPSGGSEGPQNLWKIPPHTLKPVIRISFHGRTAGNHSAYIRIK 243
            |..:.......|...|......||......||. |.:
Zfish   207 NLTQSQEDASNITILGLLLDCSLPKMFYNQPQG-WCL---------------------------- 242

  Fly   244 VAEQELDIFIPVEFEILPRHSVYARNPLADFGRVATLNAPDALQFKLDVRNDESRQLFGSYLRQI 308
            |:|:                           ||:       |||..|..|.:....|
Zfish   243 VSEE---------------------------GRI-------ALQISLSERGERPTHL-------- 265

  Fly   309 PGLSFDANNTSIVLDASLFEGDEIINDLLVINSNQSSTSPGADQPFTVLVRAEIFHGGLTFDRNA 373
                                 |::                   :|:.:             :...
Zfish   266 ---------------------DKL-------------------KPYVL-------------ENIV 277

  Fly   374 TRFVTTSPEGVEGEPLERKRSLVVRNKFAIPLMLFNVSLTEPIDESILEVTLVGDPRILIQPDES 438
            ...|...||....:|   |..:.:.|.....|.:..:.|....|.:: |:|     .:|::|..:
Zfish   278 VLLVLPPPEDAVSDP---KIGVFMLNSGVKKLFVKEIQLLSRTDSNV-ELT-----EVLLKPSAT 333

  Fly   439 ----VELL----RLNLLNDQVPFKSFLRIETNVTVFKLPLVSCSGRLHVSTQPIVLNFRQESLEK 495
                |..|    .|...:.:...:..|.|..|.||...||:..:.|...|....::..||:  ::
Zfish   334 NFTQVASLFCRHSLTAKSKRCSSQFGLHILANRTVNLYPLLQRTHRWSDSELSPLIQIRQK--QR 396

  Fly   496 AAYNLELDLGTVPFAEMSRDGFVILRNDNPVPVRITNWFFKHPKTVYSQSTFLGCRATAIGHPVS 560
            .:.::||.| |.||               |...||||
Zfish   397 GSEHVELWL-TNPF---------------PFSFRITN---------------------------- 417

  Fly   561 VENDTKGWHLCTEIRAGESAVFKVAIQTYEADATFGTLKVWTPYEVIRVRVKFEASV----GHLE 621
                         |...:..:||                          .|.|..||    |..:
Zfish   418 -------------ISLSQQKLFK--------------------------SVNFTTSVVVSSGSWK 443

  Fly   622 IDQEQLSFKNCFPGKMCTAVLSIRSSFTHPVHVKGISFALPVGLRFKDFNAKGTTIAPQTLTKVG 686
            :...||..|:.......|.:|:             .|..||:.|..:.:::.         :|.|
Zfish   444 LLSLQLLGKSLPINHRTTIILA-------------TSVGLPLELHLQTYSSS---------SKQG 486

  Fly   687 RIYFDPASVCRNNCYIRESTNDLAIFPSVPGGGNGNSGVINNNLLYDGVELRQR--TELFRQLRR 749
            .:..:.:..|...|.:|.|                .:|         .||.:|.  .|....|.|
Zfish   487 VVIVESSEECERLCPLRMS----------------RAG---------RVEWQQSLLPESSSSLWR 526

  Fly   750 QLSSMSLTLHSEELPPLELDFSITIEWPKLVQFQPIP----PTPAIEVGQVQRQWITLTNPSQSP 810
            ..||::..|.|......||    :..||:|.:....|    .||   |...:.:..||.||:.|.
Zfish   527 VDSSLASALCSRWHCSKEL----SCRWPRLPEDHSTPLDFGATP---VNDSKVKNFTLKNPTGSV 584

  Fly   811 LLLDYFLSDPAFARRTQLS--LPHEVID-------VSSTSCYLTDKEVFSLPEAGDP-------- 858
            :.::.         ||..|  :|.|.:|       :|..|..:|..| |.|..|...
Zfish   585 ISVEI---------RTLSSYPVPLEALDMLTKWFNISPLSVNITTTE-FLLLAANHKENKRGSVL 639

  Fly   859 -ILLPGGASLTIPITFSAQLPEKYCTLLHVRSNLTLYEAVWLQARAVQSQFRFGNRRPGAASPLL 922
             |||....|.|:.:.:.....:...:||.:|:|||:::.|.::....:...|.|.:.||.|:.|.
Zfish   640 RILLQPWESRTVSVAYQPTEHKPVTSLLLIRNNLTVFDMVLVKGLGAKEMLRVGGKLPGPAASLR 704

  Fly   923 FEMATNQFQGCQSG----NEAVVVTRSFTARNSGVIPIRIEGFLIGSLPCEDFGFKVMDCAGFDL 983
            |.:..:....|:.|    .....:.:||...|:|.:|:.:....|....|:.:||:|..|..|.:
Zfish   705 FNVPQSTLMECRDGLRSSKPLFAIQKSFKVENAGELPLTVVSMNINGYKCQGYGFEVQHCGSFRV 769

  Fly   984 GENEARKVEIAFSADFTTSAVKRSLTLLTNLTYDISYKLLAQMPAESVELCASLLVRPGWESSLK 1048
            ..|.:.::.|||:.|||:|.|.|.|||:|.......:.|...:|...:.|||.::..|.||.|..
Zfish   770 DYNSSSEITIAFTPDFTSSWVIRDLTLVTERGSSFHFTLNVTLPHHMLPLCAQVVPGPSWEESFW 834

  Fly  1049 NAALVVLLASFGLVLVAAVFDAKAIMVQ----------------------QNAYDAARNKGPLQ- 1090
            ...|.....|..:|.:.|...|:.|:.:                      .::...:|.||..:
Zfish   835 IITLAFTCFSLAVVCLMAFHQAQHILSEFSMPNPRSNHNSVPRENSSVNHSSSNGVSRGKGSCKN 899

  Fly  1091 --PTFNLRNIVKLQAEEAAAKAESVQQQ---QKVKNGQLKELRKRTVVNSTNSKSKSKSS----- 1145
              .|.:..:..|.:...|.|.. ||:.|   :|...|..:..:|:|.|:...|:.|:..:
Zfish   900 YTDTSHPSDKGKGRGSPAVANG-SVRLQPSSKKSSGGSSQPPKKQTKVSLLYSRYKNSPATLAAS 963

  Fly  1146 --------WSPWSMDMN----------------------AL-----SKHLQKAKPKTVVSTPVTP 1175
                    .||.:.|.:                      ||     .:|.:::|.:.|:
Zfish   964 VSATTDFCGSPTNEDKDHTFELDPEICNNNNNNNDILDEALLPVEKKEHFRESKEEKVL------ 1022

  Fly  1176 PAASAPAAAPVPLPEAKPVKKSSTPSPQGVPISVQVRPQKKVK-PTPA----------VVLGTTK 1229
            ||...|....:.|||  .:..:..|.|.|     :|...::.| .|.|          ...|:::
Zfish  1023 PAVMFPMETLLGLPE--NITANRVPQPAG-----EVMENEECKRKTNADKRDHLDEQKTERGSSQ 1080

  Fly  1230 PKQE-------VSTPVADQHEKSLAKSSPPQQENISPKPNKPPEQRVLKEQNGSAKKMGKTPGRE 1287
            .|:.       ||.|: ::.:|:..:|.....|.|   |..|....|:..::      .:.|.|.
Zfish  1081 KKRAEKDAELGVSAPI-NKTKKNAGRSRKKAPELI---PGLPENSVVMVTES------EREPSRA 1135

  Fly  1288 RERERRSKDQKLTNGTG-------AGVGFRKPERK-QRQKLNFGQTTNSTSPPESPDALKCISNP 1344
            ..|.|.:|.:....|..       :|....:|.|| ..::|.:...::|:|...|..|.:.....
Zfish  1136 AARTRNAKPELPKTGANTDSPLKHSGTCLGRPRRKCPERRLQWESGSDSSSSSGSVRASRGSWGS 1200

  Fly  1345 WETSSRV-SFRDVLRTP------QMAP-------------------TDNGFDWNHATSSSDLGPI 1383
            |.::|.: ..||..|.|      |..|                   .:|.:| .....||::||:
Zfish  1201 WSSASSIEGERDPNRHPCRRDNIQYNPYLKDQECYLNMNYTCKNPSMNNLYD-REPYQSSEMGPV 1264

  Fly  1384 GDNRKNATP-------------------PMVTSLWEPLSATASNSLFAN--TEVDFI--TPDAIY 1425
                 .|.|                   .|:...|...|...:|....|  ..:.|:  .|.:.|
Zfish  1265 -----PALPHTFADVAAGVDKNIDVIGSSMMEETWSVNSVPLTNEFRYNMSESLPFVPQNPSSRY 1324

  Fly  1426 EQREREKPQWEQRSDLVMRQQLLLQQP--------------QKLEFQLRQQEKISLLANMDPSNW 1476
            :..     .|..     |..|...|.|              .:..|...:.:.||   :.....|
Zfish  1325 DGF-----PWNN-----MSSQCSSQYPYSDRSNYMPTGNGNYQNAFSCPESQTIS---HSHQPVW 1376

  Fly  1477 ATNWSPLGYSTWPNAT--------AGIGVMRPPPGL-------EQSARQTHNLAQEQVSAGP--- 1523
            ..|.:....|||...:        :|...:.|...|       :....|:|...:......|
Zfish  1377 GENGAHDINSTWDTGSCVGSKPYFSGTRSLSPMSSLFGSIWTPQSEPYQSHFHPERSAPVSPHTP 1441

  Fly  1524 ----------ASGTGAALHGESLPTQYDPFTSPSSIWSDTWRQSSQRNNHNHMN 1567
                      :...|.|..|:.. :.::||....::  |.|..||.|::::.::
Zfish  1442 HTPISPVAPFSREPGGACPGKHF-SSFNPFGPHMNL--DIWNSSSNRSSNSQLS 1492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8370	NP_001286471.1	TMEM131_like	54..137	CDD:289165	27/78 (35%)
tmem131l	XP_693816.8	TMEM131_like	87..168	CDD:315119	27/78 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580601
Domainoid	1	1.000	56	1.000	Domainoid score	I11016
eggNOG	1	0.900	-	-		E1_KOG3620
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22050
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.930