Protein Alignment Tmem131 and Tmem131

DIOPT Version :10

• Sequence 1: NP_611073.2
• Gene: Tmem131 / 36761
• FlyBaseID: FBgn0034060
• Length: 1567
• Species: Drosophila melanogaster
• Sequence 2: NP_061360.2
• Gene: Tmem131 / 56030
• MGIID: 1927110
• Length: 1877
• Species: Mus musculus
• Alignment Length: 1926
• Identity: 466/1926 - (24%)
• Similarity: 743/1926 - (38%)
• Gaps: 489/1926 - (25%)

  Fly    13 IFAEPILLILIFLFTLGAKGEKVLQETFLGL---QEAPIH----DLGDLRLVPSRLDFGTWSVGQ 70
            |.:|.|:.:|.|     ..|..:..||.|||   |:..|.    :...:|..|..|||....||.
Mouse    63 IQSESIIEVLRF-----DDGGLLQTETTLGLGSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGM 122

  Fly    71 ARSQTVTLFNQHSNRTLQLNAVAGPSPAFYSSFLGTREVPPQGNTTFNVVFLPRQLGAIAADLLI 135
            .:.:.|.|.|..|..|:.|.:::..:..|::||...|::.|.|||:|:||||.|.:|.:...|.|
Mouse   123 PKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVVGNVENTLFI 187

  Fly   136 HTS-FGQAELAVQGEGSECPYRLKPLVGIKAPMNATLTPEIHMYNPHERPLQILEIYSSGGEFQL 199
            :|| .|.....|.|.|...||||:|.:|.:.|:|::.:|.|:::|||..|||::|:|||||:..|
Mouse   188 NTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPLQVVEMYSSGGDLHL 252

  Fly   200 ELPSGGSEGPQNLWKIPPHTLKPVIRISFHGRTAGNHSAYIRIKVAEQELDIFI--PVEFEILPR 262
            |||:|...|.:.||:|||:..|.|:|.||..|.|.||:|:||||....:...||  |||.|:...
Mouse   253 ELPTGQQGGTRKLWEIPPYETKGVMRASFSSREADNHTAFIRIKTNASDSTEFIILPVEVEVTTA 317

  Fly   263 HSVYARNPLADFGRVATLNAPDALQFKL------DV---------RNDESRQLF--------GSY 304
            ..:|:...:.|||.:.|.:.|..|...|      ||         :||.....|        .|.
Mouse   318 PGIYSSTEMLDFGTLRTQDLPKVLNLHLLNSGTKDVPITSVRPTPQNDAITVHFKPVTLKASESK 382

  Fly   305 LRQIPGLSFDANNTSIVLDASLFEGDEIINDLLVINSNQSSTSPGADQPFTVLVRAEIFHGGLTF 369
            ..::..:||||:...   ..|.|.|.      :.:.:.:.|.|. .:.|:    :||:..|.|.|
Mouse   383 YTKVASISFDASRAK---KPSQFSGK------ITVKAKEKSYSK-LEIPY----QAEVLDGYLGF 433

  Fly   370 DRNATRF-VTTSPEGVEGEPLERKRSLVVRNKFAIPLMLFNVSLTEPIDESILEVTLVGDPRILI 433
            |..||.| :..||    .:|:|  |.:.:.|.|:..:::.:|.|.|.. ..:.:|.....| :||
Mouse   434 DHAATLFHIQDSP----ADPVE--RPIYLTNTFSFAILIHDVLLPEEA-RIMFQVHNFSQP-VLI 490

  Fly   434 QPDESVELLRLNLLNDQVPFKSFLRIE------TNVTVFKLPLVSCSGRLHVSTQPIVLNFRQES 492
            .|:||..:..|..:    |..|.:.|:      ||.:.|.||:...:|.|.....|..:..|
Mouse   491 LPNESGYIFTLFFM----PSTSSMHIDNNILLVTNASKFHLPVRVYTGFLDYFVLPPKIEER--- 548

  Fly   493 LEKAAYNLELDLGTVPFAEMSRDGFVILRNDNPVPVRITNW-FFKHPKTVYSQSTFLGCRATAIG 556
                    .:|.|.:...|.|...|.|: |.||:.:.|.:| ......::...:|..|.|:|.|.
Mouse   549 --------FIDFGVLSATEASSILFAII-NSNPIELAIKSWHIIGDGLSIELVATERGNRSTVIA 604

  Fly   557 HPVSVENDTKGWHLCTEIRAGESAVFKVAIQTYEADATF-GTLKVWTPYEVIRVRVKFEASVGHL 620
            ....:|..:........:.:|..|||:|.:...:.:... |.:::.|.||::.:.||...:||.|
Mouse   605 SLPELERSSLPDQSPVTLASGHFAVFRVKLTAKKLEGVHDGAIQITTDYEILTIPVKAVIAVGSL 669

  Fly   621 EIDQEQLSFKNCFPGKMCTAVLSIRSSFTHPVHVKGI-SFALPVGLRFKDFNAKGTTIAPQTLTK 684
            ....:.:.....||||:....|:|.:||:..|.::.| |.:..|...:|........:.|...:|
Mouse   670 TCFPKHMVLPPSFPGKIVHQSLNIMNSFSQKVKIQQIRSLSEDVRFYYKRLRGNREDLEPGKKSK 734

  Fly   685 VGRIYFDPASVCRNNCYIR---ESTNDLAIFPSVPGGGNGNSGVINNNLLYD------------- 733
            :..|||||...|.::|||.   .|.::..:.|          ||.....|:|
Mouse   735 IANIYFDPGLQCGDHCYIGLPFLSKSEPKVQP----------GVAMQEDLWDADWDAHQSLFKAW 789

  Fly   734 -------GVELRQRTELFRQLRRQLSSMSLTLHSEELPPLELDFSITIEWPKLVQFQPIPPTPAI 791
                   |..|....|:...|::.:.|               ..|..:.||.::....:...|..
Mouse   790 MGIKENAGHRLNAMFEVNTDLQKNIVS---------------KVSAELSWPSVLSSPRLLKFPLT 839

  Fly   792 EVGQVQRQWITLTNPSQSPLLLDY----FLSDPA-FARR----------TQLSLPHEVIDVSSTS 841
            .......:.|:|.||:..|:.:.:    ..|:|: ||.:          .:|.|......|...|
Mouse   840 NTNCSSEEEISLENPADVPVYVQFIPLALYSNPSVFADKLVSRFNLSKVAKLDLRTLEFQVYRNS 904

  Fly   842 CY-----------LTDKEVFSLPEAGDPILLPGGASLTIPITFSAQLPEKYCTLLHVRSNLTLYE 895
            .:           |:...:.:|      ||.| |...::.:.|:........:|:.||:|||:.:
Mouse   905 AHPLQSPTGFTEGLSRHFILNL------ILKP-GEKKSVKVKFTPLHNRTVSSLIIVRNNLTVMD 962

  Fly   896 AVWLQARAVQSQFRFGNRRPGAASPLLFEMATNQFQGC----QSGNEAVVVTRSFTARNSGVIPI 956
            ||.:|.:......|...:.||..|.|.|::.....:.|    :.......:.|:|...|:|.:.|
Mouse   963 AVMVQGQGTTENLRVAGKLPGPGSSLRFKITEALLKDCIDRLKLREPNFTLKRTFKVENTGQLEI 1027

  Fly   957 RIEGFLIGSLPCEDFGFKVMDCAGFDLGENEARKVEIAFSADFTTSAVKRSLTLLTNLTYDISYK 1021
            |:|...|....||.:||||::|..|.|..|.:|.:.|.|:.|||.|.|.|.|..:|:...:..:.
Mouse  1028 RVETIEISGYACEGYGFKVVNCQEFALSANASRDIVILFTPDFTASRVIRELKFVTSSGSEFVFV 1092

  Fly  1022 LLAQMPAESVELCASLLVRPGWESSLKNAALVVLLASFGLVLVAAVFDAKAI---MVQQNAYDAA 1083
            |.|.:|...:..||..|.||.||.:|......|:.|.|.||:..|..:|:.|   ..::.:::|:
Mouse  1093 LNASLPYHMLAACAEALPRPNWELALYIIISGVMSALFLLVIGTAYLEAQGIWEPFRRRLSFEAS 1157

  Fly  1084 RNKGPLQPTFNLRNIVKLQAE------------------EAAAKAESVQQQQ------------- 1117
            .....:...|:||.||.:.:|                  .|:::..:...:|
Mouse  1158 NPPFDVGRPFDLRRIVGISSEGNLNTLGCEHSHGRGFYSNASSRPGTGSHRQCGTSVHPHSSHGS 1222

  Fly  1118 -------KVKNGQLKELRKRTVVNSTNSKSKSKSSWSP--------------------------- 1148
                   .|:......:..||...:..|:|.||:  ||
Mouse  1223 KNSADVDNVRTRNSSSMSSRTSPQAAASQSTSKT--SPLVSETAAATQGHTASRKSRGAKQGQHS 1285

  Fly  1149 ---WSMDMNALSKHLQKAKPKTVVSTPVTPPAASAPAAAPVPLPEAKPVKKSST----------- 1199
               .|...:.|.:|.|...|......|  ||...:|  ||:..| :.|.:.|:|
Mouse  1286 SQHHSHSHSPLEQHSQPPPPVPQHQEP--PPERLSP--APLTHP-SHPERASTTRHSSEDSDITS 1345

  Fly  1200 ------------------------PSP----QGVPISVQVRPQKKVKP----TPAVVLGTTKPKQ 1232
                                    |||    :|...|:|   |:|.||    ......|..||::
Mouse  1346 LIEAMDKDFDHHDSSPLDVFTEQPPSPMSKSKGKGKSLQ---QRKAKPPKKQEEKEKRGKGKPQE 1407

  Fly  1233 -----------------EVSTP-----VADQHEKSLAKSSPPQQENISPKPNKPPEQRVLK---- 1271
                             |.|.|     :.:..||...:.:.|:::.......||..:::|.
Mouse  1408 DELKDALADDDSSSTTTETSNPDTEPLLREDTEKHKGRPAVPEKQESELSQGKPKSKKLLNAKKE 1472

  Fly  1272 ---EQNGSAKKMGKTPGRERERERRSKDQKLTNGTGAGVGFRK---PERKQRQKL---------- 1320
               :..||:.::..||..| .::||:...|:...|....|.:.   |:.|...||
Mouse  1473 IPTDVKGSSFELPYTPSLE-NKQRRNLPTKIPLPTTLASGSKSRNPPKTKGTNKLVENRPVALSK 1536

  Fly  1321 ------NFGQTTNS-----TSPPE-----------SPDALKCIS--------------------- 1342
                  ..|.|::|     :.|||           |.|:|..:|
Mouse  1537 FLPSSQELGNTSSSEGEKDSPPPEWDAVPVHKPSSSTDSLYKLSLQTLNADIFLKQRQTSPTPAS 1601

  Fly  1343 -----NPWETSSRVSFRDVLRT-----------------------------PQMA---------P 1364
                 .|...:||.|:..|:.:                             |..|         |
Mouse  1602 PSLPTAPCPFTSRGSYSSVVNSSGSDTKAKQTSSSKSKLTKAASLPGKNGNPTFAAVAAGYDKSP 1666

  Fly  1365 TDNGF---DWNHATSSSDLG----PIGDNRKNATPPMVTSLWEPLS------ATASNSL--FANT 1414
            ..|||   ..|.:..||.||    |:..:..::     :.||.|:|      .|..||.  |.|:
Mouse  1667 GGNGFAKISSNKSDFSSSLGISHIPVDSDGSDS-----SGLWSPVSNPNSPDFTPLNSFSAFGNS 1726

  Fly  1415 EVDFITPDAIYEQREREKPQWEQRS--DLVMRQQLLLQQPQ-------KLEFQLRQQEKISLLAN 1470
               |....|::.:..|...|..|||  :.......|...|.       ............|:|.|
Mouse  1727 ---FNLTGAVFSKLSRSCSQSSQRSWNEFNSGPSYLWDSPATDPSPSWPASSSSPTHTATSILGN 1788

  Fly  1471 ---------MDPSNWATNW-SPLGYSTWPNATAGIGVMRPPPGLEQSARQTHNLAQEQVSAGPAS 1525
                     ...|.|::|. |.|.:||..||.:.|.:|    |.|.||     .|....::|||.
Mouse  1789 SSGLWSTTPFSSSIWSSNINSNLPFSTPTNALSSISLM----GTENSA-----AAHTPSASGPAD 1844

  Fly  1526 GTGAALHGESLPTQYDPFTSPSSIWSDT-WRQSSQRNNHNH 1565
            ..|..         |:|:    .|||.| .|:||...:::|
Mouse  1845 DLGQT---------YNPW----RIWSPTVGRRSSDPWSNSH 1872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmem131	NP_611073.2	TMEM131_like_N	54..137	CDD:463553	30/82 (37%)
		TMEM131_like	<880..>1064	CDD:437364	61/187 (33%)
Tmem131	NP_061360.2	PapD-L domain. /evidence=ECO:0000250|UniProtKB:Q92545	107..281		73/174 (42%)
		TMEM131_like_N	107..189	CDD:463553	31/82 (38%)
		TMEM131_like	340..>1230	CDD:437364	236/1046 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1197..1573		117/610 (19%)
		PTZ00449	<1351..1648	CDD:185628	84/399 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1590..1655		10/27 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1679..1707
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1830..1852