DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8370 and tmem131

DIOPT Version :9

Sequence 1:	NP_001286471.1	Gene:	CG8370 / 36761	FlyBaseID:	FBgn0034060	Length:	1567	Species:	Drosophila melanogaster
Sequence 2:	XP_005166018.1	Gene:	tmem131 / 557719	ZFINID:	ZDB-GENE-130530-662	Length:	1800	Species:	Danio rerio

Alignment Length:	1888	Identity:	446/1888 - (23%)
Similarity:	742/1888 - (39%)	Gaps:	424/1888 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TQVQMRP---------LLRIFAEPILLILIFLFTLGA------KGEKVLQETFLG----LQEAPI 48
            ||..:.|         |||      ||.:.|:....|      :.:.:|:....|    ||....
Zfish     7 TQSSLHPTRTKSACVGLLR------LLFIAFIHVAQANKQAFIQSDNILEVLHFGDGSLLQTESD 65

  Fly    49 HDLGD---------------LRLVPSRLDFGTWSVGQARSQTVTLFNQHSNRTLQLNAVAGPSPA 98
            .||..               :|..|..|||....||..:.:.|.|.|. |:..:.|.:::..:..
Zfish    66 IDLSSYRQKSASSQRGNSRPIRFEPPMLDFHEQPVGMPKMEKVYLHNP-SSEEISLISISATTSH 129

  Fly    99 FYSSFLGTREVPPQGNTTFNVVFLPRQLGAIAADLLIHTS-FGQAELAVQGEGSECPYRLKPLVG 162
            |::||...|.:||.|||:|:||||.|.:|.:...|.|:|| .|.....|.|.|...||||:|.||
Zfish   130 FHASFFQNRIIPPGGNTSFDVVFLARVVGNVENTLFINTSHHGVFTYQVFGVGVPNPYRLRPFVG 194

  Fly   163 IKAPMNATLTPEIHMYNPHERPLQILEIYSSGGEFQLELPSGGSEGPQNLWKIPPHTLKPVIRIS 227
            .:.|:|::.:|.|.::|||..|||::|:|:|||:..||||:|...|.:.||:|.|...|.|:|.|
Zfish   195 ARVPVNSSFSPLISIFNPHSEPLQVVEMYTSGGDLHLELPTGQQGGTKKLWEIAPFETKGVMRAS 259

  Fly   228 FHGRTAGNHSAYIRIKVAEQELDIFI--PVEFEILPRHSVYARNPLADFGRVATLNAPDALQFKL 290
            |..|.|.||:|:||||......|.||  |||.|:.....:|:...:.|||.:.:.:.|.  |..|
Zfish   260 FSSRDADNHTAFIRIKTNASNEDEFIILPVEVEVTTAPGIYSSTEMLDFGTLRSQDRPK--QLNL 322

  Fly   291 DVRNDESRQLFGSYLRQIP----------------GLSFDANNTSIVLDASLFEGDEIINDLLVI 339
            .:.|..::.:....:|..|                |.|......||..|||.....:..:..:.:
Zfish   323 HLLNSGAKDVSIMSVRPTPSNEAVTVEFKPITLKAGESRYTKVASISFDASKARRSDQFSGKITV 387

  Fly   340 NSNQSSTSPGADQPFTVLVRAEIFHGGLTFDRNATRF-VTTSPEGVEGEPLERKRSLVVRNKFAI 403
            .:.:.|.|. .:.|:    :||:..|.|.||..||.| :..||.    :|::  |.:.:.|.|..
Zfish   388 KAKEKSYSK-LEIPY----QAEVLEGYLGFDHTATLFHIRDSPV----DPVD--RPIYLTNTFNF 441

  Fly   404 PLMLFNVSLTEPIDESILEVTLVGDPRILIQPDES--VELLRLNLLNDQVPFKSFLRIETNVTVF 466
            .:.:.||||.:.. :::..|.....| :||.|.||  :..|....:...:...|.:.:.||.:.|
Zfish   442 AIRIHNVSLPKEA-KTMFNVHNFSTP-VLIPPHESRYIFSLLFRPVRPSIHIDSNILLITNASKF 504

  Fly   467 KLPLVSCSGRLHVSTQPIVL-NFRQESLEKAAYNLELDLGTVPFAEMSRDGFVILRNDNPVPVRI 530
            .||:.:.:|.|    :|:|| ...||.:        ||.|.:...:.|...||:: |.||:.:.|
Zfish   505 HLPVRAYTGFL----EPVVLPPCLQEHI--------LDFGVLSATDTSSLVFVVV-NSNPIELEI 556

  Fly   531 TNWFFKHPK-TVYSQSTFLGCRATAIGHPVSVENDTKGWHLCTEIRAGESAVFKVAIQTYEADAT 594
            .:|...... ::...:|..|.|:.|:.....::|.:...:....:.:|..|.|||.:.....:..
Zfish   557 KSWLVTGDSLSMELLNTERGNRSIALSRIQELQNTSAAQYKTVILASGYYAAFKVTLVAKALEGI 621

  Fly   595 F-GTLKVWTPYEVIRVRVKFEASVGHLEIDQEQLSFKNCFPGKMCTAVLSIRSSFTHPVHVKGI- 657
            : |.:.:.|.||::.:.||...:||.|....:.:...:.||||:....|||:|||:..|.::.|
Zfish   622 YDGAVHITTDYEILTIPVKALIAVGTLSCSPKHIILPDAFPGKVVHQGLSIQSSFSQKVRLQQIR 686

  Fly   658 SFALPVGLRFKDFNAKGTTIAPQTLTKVGRIYFDPASVCRNNCYIRESTNDLAIFPSVPGGGNGN 722
            |....|..::|........:.|:..:|:..||||.:..|.::||:.        .|.|....:..
Zfish   687 SLTEDVRFQYKRVRNNKVELEPRRKSKIANIYFDASLQCGDHCYVG--------LPFVLKSESRP 743

  Fly   723 SGVINNNLLYDG-VELRQR-TELFRQLRRQLSSMSLTLHSEEL---------PPLELDFSITIEW 776
            .|::....::|. |:|.|| .:.:|:|:.|..      |..|.         ..::...|..::|
Zfish   744 HGLVMQEDMWDADVDLHQRLLKRWRELKEQSG------HEVEAFFEVDTDLQKNVQAKISAKLKW 802

  Fly   777 PKLVQFQPIPPTPAIEVGQVQRQWITLTN---PSQSPLLLDYFLSDPAFARRTQLSL-PHEVIDV 837
            |.|:.            ..:|:....|||   .|:..::|:.....|.:.:...|:| |:..:..
Zfish   803 PSLLN------------STLQQIHFPLTNTNSSSEEEVILENSADVPVYVQVLPLALYPNPSVFT 855

  Fly   838 ------------------SSTSCYLTDKEVFSL-------------PEAGDPILLPGGASLTIPI 871
                              ::|..:|..|...|:             |...:.:|:||... :..:
Zfish   856 GKLADRFPLGKLSNINLDTNTLEFLVQKNHSSVMKSSTGFVEGSTRPYVYNMLLMPGEVK-SFNV 919

  Fly   872 TFSAQLPEKYCTLLHVRSNLTLYEAVWLQARAVQSQFRFGNRRPGAASPLLFEMATNQFQGC--- 933
            .|.........:||.||:|||:.:.:.:..:......|...:.||..|.|.|::..:..:.|
Zfish   920 RFRPTTNHSVSSLLVVRNNLTIVDLIMVHGQGTTESLRLAGKAPGLGSSLRFKLTESFLKDCSEV 984

  Fly   934 QSGNEAVVVTRSFTARNSGVIPIRIEGFLIGSLPCEDFGFKVMDCAGFDLGENEARKVEIAFSAD 998
            ::......:.|:|...|:|::||.|....|....||.:||||::|..|.|..|.::.:.|.|:.|
Zfish   985 KAKEPNFTLRRTFRLENTGLLPIHIRSVEISGNACEGYGFKVLNCEEFALKPNTSKDLIILFTPD 1049

  Fly   999 FTTSAVKRSLTLLTNLTYDISYKLLAQMPAESVELCASLLVRPGWESSLKNAALVVLLASFGLVL 1063
            ||:|.|.|.|.|:|......::.|.|.:|...:.:||.:|.||.||..|.....:|:.:.|.||:
Zfish  1050 FTSSRVIRELKLVTAGGSVFAFVLNASLPYHMLAVCAEMLPRPNWELELYIIVSLVMSSMFLLVI 1114

  Fly  1064 VAAVFDAKAIMVQQNAYDAARNKGPLQ--PTFNLRNIVKLQAEE--------------------- 1105
            ..|..:|:.|........:..:..|::  ..|:||.||::|::.
Zfish  1115 ATAYLEAQGIWEPFKRRLSVESNSPMETGKPFDLREIVRIQSDPNLNDFADSNQNSTRGMYGSSI 1179

  Fly  1106 --AAAKAESVQQQQKVKNGQLKELRKRTVVNSTNSKSKSKSSWSPWSMDMN-----------ALS 1157
              .|...:|........||.|.:.:.|    |.:.:|.|..|.|.:|:..|           |.|
Zfish  1180 GGRAGGRQSGSHSSSNSNGVLPDSKPR----SGSGRSGSMQSSSTFSLKDNGPGLNQVTNRKARS 1240

  Fly  1158 KHLQKAKPKTVVSTPVTPPAASAPAAA-----------------PVPLPEAKPVKKS----STPS 1201
            ...|:.....:...|.|.|:.|..|..                 .:..||:..:..|    |..|
Zfish  1241 SKQQQQGSGLLEDLPSTGPSQSNSARVNSTEDQDYNRLLVAMDKDLDRPESPAINVSSEHNSQQS 1305

  Fly  1202 PQGVPISVQVRPQKKVK-PTPAVVLGTTKPK--------QEVSTPVADQHE-------------- 1243
            .|...:..:.:.:.||| .|.|:.....|.:        ::...|:||..:
Zfish  1306 SQNKVLESKGKNETKVKNKTKALKKKEEKERKTKGKTQGEDFKEPLADNDDSSSTTTETSNPDVE 1370

  Fly  1244 ------------KSLAKSSPPQQENISPKPNKP--PEQRVLKEQNGSAKKMG-----KTPGRERE 1289
                        |::|..:..::|.|:|.|.||  .:|...|::|...|...     .||..:::
Zfish  1371 ANIKEEPVKVKGKTVAIDNGKEREEITPSPTKPKSKKQPTTKKENPVEKSSSLELPYVTPLEKQD 1435

  Fly  1290 RERR------------SKDQKLTNGTGAGVGFRKPERKQRQKLN-----FGQTTNSTSPPESP-- 1335
            :.:.            ||.:.|:....|.:|..:|....:...|     .|.::.|....|||
Zfish  1436 KRKNFKTLASTAIPGVSKPRALSKLVNAKMGDDRPSPLGKFVSNGSMPELGHSSGSEGEKESPPP 1500

  Fly  1336 -------------DALKCIS---------------------NPWETSSRVSFRDVLRTPQMAPTD 1366
                         |:|:.||                     :|..||           |.:.|..
Zfish  1501 EWDVPLNKNGNQADSLQQISMQTMHADPFLKGPSSVINRTCSPPPTS-----------PSLVPHG 1554

  Fly  1367 NGFDWNHATSSSDLGPIGDNR---------KNATP------------------------------ 1392
            :.....|.:|..:|.....|:         :|..|
Zfish  1555 SYSSMMHPSSEINLKKAPGNKLTKSASLPGQNGNPTFAAVAAGYDKSPGGSGCASKADGLGKVAL 1619

  Fly  1393 PMVTS----------LWEPLSATASNSLFANTEVDFITPDAIYEQREREKPQWEQRSDLVMRQQL 1447
            |.:||          ||.|:.:|:|.|.   .:|:..:...         |........|.|...
Zfish  1620 PHMTSVESDGSDSSGLWSPVDSTSSPSF---NQVNAFSAFG---------PNNPLNLSGVFRGMT 1672

  Fly  1448 LLQQPQKLEFQLRQQEKISLLANMDPSNWAT----NWSPLGYSTWPNATAGIGVMRPPPGLEQSA 1508
            :   |:..|.|....|    ...:.||.|.|    :|:.:..|.....|:.:|..|.|.....|.
Zfish  1673 V---PKSSESQQSWPE----YTPVSPSIWDTETDNSWTTITGSPATPTTSILGSARSPWSFSSSI 1730

  Fly  1509 RQTHNLAQEQVSAGPASGTGAALHGESLP---------TQYDPFT---SPS-SIW-SDTWRQSSQ 1559
            ..|.|.:.....:.||:.|...|...:.|         ..|:|::   ||| :.| |:.|..|..
Zfish  1731 WSTGNDSTLHSFSPPATSTLPDLVSHTAPPTPAPNDMGRTYNPWSMGWSPSLNRWNSEPWPNSPD 1795

  Fly  1560 RNN 1562
            .||
Zfish  1796 NNN 1798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8370	NP_001286471.1	TMEM131_like	54..137	CDD:289165	30/82 (37%)
tmem131	XP_005166018.1	TMEM131_like	87..168	CDD:315119	30/81 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580600
Domainoid	1	1.000	323	1.000	Domainoid score	I1184
eggNOG	1	0.900	-	-		E1_KOG3620
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	371	1.000	Inparanoid score	I2078
OMA	1	1.010	-	-		QHG47821
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007382
OrthoInspector	1	1.000	-	-		oto39375
orthoMCL	1	0.900	-	-		OOG6_106557
Panther	1	1.100	-	-	O	PTHR22050
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3696
SonicParanoid	1	1.000	-	-		X5506
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790