Protein Alignment Tmem131 and TMEM131

DIOPT Version :10

• Sequence 1: NP_611073.2
• Gene: Tmem131 / 36761
• FlyBaseID: FBgn0034060
• Length: 1567
• Species: Drosophila melanogaster
• Sequence 2: XP_047299798.1
• Gene: TMEM131 / 23505
• HGNCID: 30366
• Length: 1973
• Species: Homo sapiens
• Alignment Length: 1953
• Identity: 461/1953 - (23%)
• Similarity: 745/1953 - (38%)
• Gaps: 519/1953 - (26%)

  Fly     3 TQVQMRPLLRIFAEPILLILIFLFTLGAKGEKVLQETFLGL---QEAPIH----DLGDLRLVPSR 60
            |.:.:.||..:.:|.|:.:|.|     ..|..:..||.|||   |:..|.    :...:|..|..
Human   145 TFLPLGPLAFVQSESIIEVLRF-----DDGGLLQTETTLGLSSYQQKSISLYRGNCRPIRFEPPM 204

  Fly    61 LDFGTWSVGQARSQTVTLFNQHSNRTLQLNAVAGPSPAFYSSFLGTREVPPQGNTTFNVVFLPRQ 125
            |||....||..:.:.|.|.|..|..|:.|.:::..:..|::||...|::.|.|||:|:||||.|.
Human   205 LDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARV 269

  Fly   126 LGAIAADLLIHTS-FGQAELAVQGEGSECPYRLKPLVGIKAPMNATLTPEIHMYNPHERPLQILE 189
            :|.:...|.|:|| .|.....|.|.|...||||:|.:|.:.|:|::.:|.|:::|||..|||::|
Human   270 VGNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPLQVVE 334

  Fly   190 IYSSGGEFQLELPSGGSEGPQNLWKIPPHTLKPVIRISFHGRTAGNHSAYIRIKVAEQELDIFI- 253
            :|||||:..||||:|...|.:.||:|||:..|.|:|.||..|.|.||:|:||||....:...||
Human   335 MYSSGGDLHLELPTGQQGGTRKLWEIPPYETKGVMRASFSSREADNHTAFIRIKTNASDSTEFII 399

  Fly   254 -PVEFEILPRHSVYARNPLADFGRVATLNAPDALQFKL------DV---------RNDESRQLF- 301
             |||.|:.....:|:...:.|||.:.|.:.|..|...|      ||         :||.....|
Human   400 LPVEVEVTTAPGIYSSTEMLDFGTLRTQDLPKVLNLHLLNSGTKDVPITSVRPTPQNDAITVHFK 464

  Fly   302 -------GSYLRQIPGLSFDANNTSIVLDASLFEGDEIINDLLVINSNQSSTSPGADQPFTVLVR 359
                   .|...::..:||||:...   ..|.|.|.      :.:.:.:.|.|. .:.|:    :
Human   465 PITLKASESKYTKVASISFDASKAK---KPSQFSGK------ITVKAKEKSYSK-LEIPY----Q 515

  Fly   360 AEIFHGGLTFDRNATRF-VTTSPEGVEGEPLERKRSLVVRNKFAIPLMLFNVSLTEPIDESILEV 423
            ||:..|.|.||..||.| :..||    .:|:|  |.:.:.|.|:..:::.:|.|.|.. :::.:|
Human   516 AEVLDGYLGFDHAATLFHIRDSP----ADPVE--RPIYLTNTFSFAILIHDVLLPEEA-KTMFKV 573

  Fly   424 TLVGDPRILIQPDESVELLRLNLLNDQVPFKSFLRIE------TNVTVFKLPLVSCSGRLHVSTQ 482
            .....| :||.|:||..:..|..:    |..|.:.|:      ||.:.|.||:...:|.|.....
Human   574 HNFSKP-VLILPNESGYIFTLLFM----PSTSSMHIDNNILLITNASKFHLPVRVYTGFLDYFVL 633

  Fly   483 PIVLNFRQESLEKAAYNLELDLGTVPFAEMSRDGFVILRNDNPVPVRITNW-FFKHPKTVYSQST 546
            |..:..|           .:|.|.:...|.|...|.|: |.||:.:.|.:| ......::...:.
Human   634 PPKIEER-----------FIDFGVLSATEASNILFAII-NSNPIELAIKSWHIIGDGLSIELVAV 686

  Fly   547 FLGCRATAIGHPVSVENDTKGWHLCTEIRAGESAVFKVAIQTYEADATF-GTLKVWTPYEVIRVR 610
            ..|.|.|.|......|..:........:.:|..|||:|.:...:.:... |.:::.|.||::.:.
Human   687 ERGNRTTIISSLPEFEKSSLSDQSSVTLASGYFAVFRVKLTAKKLEGIHDGAIQITTDYEILTIP 751

  Fly   611 VKFEASVGHLEIDQEQLSFKNCFPGKMCTAVLSIRSSFTHPVHVKGI-SFALPVGLRFKDFNAKG 674
            ||...:||.|....:.:.....||||:....|:|.:||:..|.::.| |.:..|...:|......
Human   752 VKAVIAVGSLTCFPKHVVLPPSFPGKIVHQSLNIMNSFSQKVKIQQIRSLSEDVRFYYKRLRGNK 816

  Fly   675 TTIAPQTLTKVGRIYFDPASVCRNNCYIR---ESTNDLAIFPSVPGGGN--------------GN 722
            ..:.|...:|:..|||||...|.::||:.   .|.::..:.|.|....:              |.
Human   817 EDLEPGKKSKIANIYFDPGLQCGDHCYVGLPFLSKSEPKVQPGVAMQEDMWDADWDLHQSLFKGW 881

  Fly   723 SGVINNNLLYDGVELRQRTELFRQLRRQLSSMSLTLHSEELPPLELDFSITIE--WPKLVQFQPI 785
            :|:..|:    |..|....|:...|::.:.|                 .||.|  ||.::.....
Human   882 TGIKENS----GHRLSAIFEVNTDLQKNIIS-----------------KITAELSWPSILSSPRH 925

  Fly   786 PPTPAIEVGQVQRQWITLTNPSQSPLLLDY----FLSDPA-----FARRTQLSLPHEVIDVSSTS 841
            ...|.........:.|||.||:..|:.:.:    ..|:|:     ...|..||      .|:...
Human   926 LKFPLTNTNCSSEEEITLENPADVPVYVQFIPLALYSNPSVFVDKLVSRFNLS------KVAKID 984

  Fly   842 CYLTDKEVFSLPEAGDP------------------ILLPGGASLTIPITFSAQLPEKYCTLLHVR 888
            ....:.:||.  .:..|                  ::|..|...::.:.|:........:|:.||
Human   985 LRTLEFQVFR--NSAHPLQSSTGFMEGLSRHLILNLILKPGEKKSVKVKFTPVHNRTVSSLIIVR 1047

  Fly   889 SNLTLYEAVWLQARAVQSQFRFGNRRPGAASPLLFEMATNQFQGCQSG----NEAVVVTRSFTAR 949
            :|||:.:||.:|.:......|...:.||..|.|.|::.....:.|...    .....:.|:|...
Human  1048 NNLTVMDAVMVQGQGTTENLRVAGKLPGPGSSLRFKITEALLKDCTDSLKLREPNFTLKRTFKVE 1112

  Fly   950 NSGVIPIRIEGFLIGSLPCEDFGFKVMDCAGFDLGENEARKVEIAFSADFTTSAVKRSLTLLTNL 1014
            |:|.:.|.||...|....||.:||||::|..|.|..|.:|.:.|.|:.|||.|.|.|.|..:|..
Human  1113 NTGQLQIHIETIEISGYSCEGYGFKVVNCQEFTLSANASRDIIILFTPDFTASRVIRELKFITTS 1177

  Fly  1015 TYDISYKLLAQMPAESVELCASLLVRPGWESSLKNAALVVLLASFGLVLVAAVFDAKAI---MVQ 1076
            ..:..:.|.|.:|...:..||..|.||.||.:|......::.|.|.||:..|..:|:.|   ..:
Human  1178 GSEFVFILNASLPYHMLATCAEALPRPNWELALYIIISGIMSALFLLVIGTAYLEAQGIWEPFRR 1242

  Fly  1077 QNAYDAARNKGPLQPTFNLRNIVKLQAE------------------------------------- 1104
            :.:::|:.....:...|:||.||.:.:|
Human  1243 RLSFEASNPPFDVGRPFDLRRIVGISSEGNLNTLSCDPGHSRGFCGAGGSSSRPSAGSHKQCGPS 1307

  Fly  1105 ---------EAAAKAESVQQQQKVKNGQLKELRKRTVVNSTNSKSKSKSSWSPWSMDMNALSK-H 1159
                     ..:|..|:|    :.||.  .....||...:.:|:|.:|:  ||..:|.|.::: |
Human  1308 VHPHSSHSNRNSADVENV----RAKNS--SSTSSRTSAQAASSQSANKT--SPLVLDSNTVTQGH 1364

  Fly  1160 L--QKAK--------------------PKTVVSTPVTPPAASAP-AAAPVPL-----PE-AKPVK 1195
            .  :|:|                    |:..:..||..|....| ..:|.||     || |...:
Human  1365 TAGRKSKGAKQSQHGSQHHAHSPLEQHPQPPLPPPVPQPQEPQPERLSPAPLAHPSHPERASSAR 1429

  Fly  1196 KSS------------------------------TPSP------QGVPISVQVRPQKKVKPTPAVV 1224
            .||                              .|||      :|.|:..:|:|.||.:....
Human  1430 HSSEDSDITSLIEAMDKDFDHHDSPALEVFTEQPPSPLPKSKGKGKPLQRKVKPPKKQEEKEK-- 1492

  Fly  1225 LGTTKPKQ-----------------EVSTP-----VADQHEKSLAKSSPPQQENISPKPNKPPEQ 1267
            .|..||::                 |.|.|     :.:..||...|.:.|::........|...:
Human  1493 KGKGKPQEDELKDSLADDDSSSTTTETSNPDTEPLLKEDTEKQKGKQAMPEKHESEMSQVKQKSK 1557

  Fly  1268 RVLK-------EQNGSAKKMGKTPGRERERER----------------RSKDQKLTNGTGAGVGF 1309
            ::|.       :...|:.::..||..|.::.|                :|::.:.|.||...|..
Human  1558 KLLNIKKEIPTDVKPSSLELPYTPPLESKQRRNLPSKIPLPTAMTSGSKSRNAQKTKGTSKLVDN 1622

  Fly  1310 RKPERKQ----RQKLNFGQTTNS-----TSPPE-------------------------------- 1333
            |.|...:    .|:|  |.|::|     :.|||
Human  1623 RPPALAKFLPNSQEL--GNTSSSEGEKDSPPPEWDSVPVHKPGSSTDSLYKLSLQTLNADIFLKQ 1685

  Fly  1334 ----------SPDALKC---------------------ISNPWETSSRV-------------SFR 1354
                      ||.|..|                     |..|..:..::             :|.
Human  1686 RQTSPTPASPSPPAAPCPFVARGSYSSIVNSSSSSDPKIKQPNGSKHKLTKAASLPGKNGNPTFA 1750

  Fly  1355 DVLRTPQMAPTDNGF---DWNHATSSSDLG----PIGDNRKNATPPMVTSLWEPLSATASN---- 1408
            .|......:|..|||   ..|....||.||    |:..:..::     :.||.|:|..:|.
Human  1751 AVTAGYDKSPGGNGFAKVSSNKTGFSSSLGISHAPVDSDGSDS-----SGLWSPVSNPSSPDFTP 1810

  Fly  1409 ----SLFANT-----EV-------------------DFIT-PDAIYEQRERE-KPQWEQRSDLVM 1443
                |.|.|:     ||                   :|.: |..::|....: .|.|...|.
Human  1811 LNSFSAFGNSFNLTGEVFSKLGLSRSCNQASQRSWNEFNSGPSYLWESPATDPSPSWPASSG--- 1872

  Fly  1444 RQQLLLQQPQKLEFQLRQQEKISLLAN---------MDPSNWATNW-SPLGYSTWPNATAGIGVM 1498
                   .|        .....|:|.|         ...|.|::|. |.|.::|..|..|.||:|
Human  1873 -------SP--------THTATSVLGNTSGLWSTTPFSSSIWSSNLSSALPFTTPANTLASIGLM 1922

  Fly  1499 RPPPGLEQSARQTHNLAQEQVSAGPASGTGAALHGESLPTQYDPFTSPSSIWSDT-WRQSSQRNN 1562
                |.|.|          .....|::.:.|    :.|...|:|:    .|||.| .|:||...:
Human  1923 ----GTENS----------PAPHAPSTSSPA----DDLGQTYNPW----RIWSPTIGRRSSDPWS 1965

  Fly  1563 HNH 1565
            ::|
Human  1966 NSH 1968

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmem131	NP_611073.2	TMEM131_like_N	54..137	CDD:463553	30/82 (37%)
		TMEM131_like	<880..>1064	CDD:437364	60/187 (32%)
TMEM131	XP_047299798.1	TMEM131_like_N	199..281	CDD:463553	30/81 (37%)
		TMEM131_like	432..>1303	CDD:437364	215/937 (23%)