Protein Alignment Tmem131 and TMEM131L

DIOPT Version :10

• Sequence 1: NP_611073.2
• Gene: Tmem131 / 36761
• FlyBaseID: FBgn0034060
• Length: 1567
• Species: Drosophila melanogaster
• Sequence 2: XP_047305855.1
• Gene: TMEM131L / 23240
• HGNCID: 29146
• Length: 1658
• Species: Homo sapiens
• Alignment Length: 1444
• Identity: 287/1444 - (19%)
• Similarity: 483/1444 - (33%)
• Gaps: 435/1444 - (30%)

  Fly    54 LRLVPSRLDFGTWSVGQARSQTVTLFNQHSNRTLQLNAVAGPSPAFYSSFLGTREVPPQGNTTFN 118
            |...||.||||...:|...::.:..:|...:..:.:|:|...:..|:...:..|.:|..|.|:|.
Human   120 LHFQPSVLDFGIQFLGHPVAKILHAYNPSRDSEVVVNSVFAAAGHFHVPPVPCRVIPAMGKTSFR 184

  Fly   119 VVFLPRQLGAIAADLLIHT-SFGQAELAVQGEGSECPYRLKPLVGIKAPMNATLTPEIHMYNPHE 182
            ::|||.:.|:|.:.|.|:| |:|.....|.|.|:.
Human   185 IIFLPTEEGSIESSLFINTSSYGVLSYHVSGIGTR------------------------------ 219

  Fly   183 RPLQILEIYSSGGEFQLELPSGGSEGPQNLWKIPPHTLKPVIRISFHGRTAGNHSAYIRIKVAEQ 247
                                                      |||..|.             |:|
Human   220 ------------------------------------------RISTEGS-------------AKQ 229

  Fly   248 ELDIFIPVEFEILPR-HSVYARNPLADFGRVATLNAPDALQFKLDVRNDESRQLFGSYLRQIPGL 311
                 :|..:.:||: .|:......|:....:.|.    :|.:..:.|...:||.|.||.....|
Human   230 -----LPNAYFLLPKVQSIQLSQMQAETTNTSLLQ----VQLECSLHNKVCQQLKGCYLESDDVL 285

  Fly   312 SFDANNTSIVLDASLF--EGDEIINDLL------VINSNQSSTSPGADQPFTVLVRAEIFHGG-- 366
            ..   ..||::....|  |.:|....||      .:.:::|.||..:      .|...|.|.|
Human   286 RL---QMSIMVTMENFSKEFEENTQHLLDHLSIVYVATDESETSDDS------AVNMYILHSGNS 341

  Fly   367 LTFDRNATRFVTTSPEGVEGEPLERKRSLVVRNKFAIPLMLFNVSLTEPIDESILEVTLVGDPRI 431
            |.:.::...|.......::.||:....|.....|.|    .|........|..|:|.
Human   342 LIWIQDIRHFSQRDALSLQFEPVLLPTSTTNFTKIA----SFTCKAATSCDSGIIED-------- 394

  Fly   432 LIQPDESVELLRLNLLNDQVPFKSFLRIETNVTVFKLPLVSCSGRLHVSTQPIVLNFRQESLEKA 496
             ::.......|:..|.:...  :.:.|::::.|.|           |:.|..     ....|...
Human   395 -VKKTTHTPTLKACLFSSVA--QGYFRMDSSATQF-----------HIETHE-----NTSGLWSI 440

  Fly   497 AYNLELDLGTVPFAEMSRDGFVILRNDNPVPVRITNW---FFKHPKTVYSQSTFLGCRATAIGHP 558
            .|....|...|     ..|  |.|..:....::|.|:   .|..|......|..|..:..||...
Human   441 WYRNHFDRSVV-----LND--VFLSKETKHMLKILNFTGPLFLPPGCWNIFSLKLAVKDIAINLF 498

  Fly   559 VSVENDTKGWHLCTEIRAGESAVFKVAIQTYEADATFGTLKVWTPYEVIRVRVKFEASVGHLEID 623
            .:|       .|.|.|    .|:|.:.:|.|.|....|:|    .:|||       |..|
Human   499 TNV-------FLTTNI----GAIFAIPLQIYSAPTKEGSL----GFEVI-------AHCG----- 536

  Fly   624 QEQLSFKNCFPGKMCTAVLSIRSSFTHPVHVKGISFALPVGLRFKDFNAKGTTIAPQTLTKVGRI 688
                  .:.|.||         |...:|                   |..|:....|:...|.
Human   537 ------MHYFMGK---------SKAGNP-------------------NWNGSLSLDQSTWNVD-- 565

  Fly   689 YFDPASVCRNNCYIRESTNDLAIFPSVPGGGNGNSGVINNNLLYDGVELRQRTELFRQLRRQLSS 753
                 |...|..|.|.....             |..|...|:|        .|..|..|::...|
Human   566 -----SELANKLYERWKKYK-------------NGDVCKRNVL--------GTTRFAHLKKSKES 604

  Fly   754 MSLTLHSEEL---PPLELDFSITI---------------EWPKLVQFQPIP--PTPAIEVGQVQR 798
            .|.......|   |.|.|:||.|.               .||..:|..|:.  |.|...|..:.|
Human   605 ESFVFFLPRLIAEPGLMLNFSATALRSRMIKYFVVQNPSSWPVSLQLLPLSLYPKPEALVHLLHR 669

  Fly   799 QWITLTNPSQSPLLLDYFLSDPAFARRTQLSLPHEVIDVSSTSCYLTDKEVFSLPEAG------- 856
                            :|.:|            .::|:.::....||:    :.|..|
Human   670 ----------------WFGTD------------MQMINFTTGEFQLTE----ACPYLGTHSEESR 702

  Fly   857 --------DPILLPGGASLTIPITFSAQLPEKYCTLLHVRSNLTLYEAVWLQARAVQSQFRFGNR 913
                    .|:.:.     .:.:.|:.....|..:|:.:|:|||:.:.:.::....:...:.|.|
Human   703 FGILHLHLQPLEMK-----RVGVVFTPADYGKVTSLILIRNNLTVIDMIGVEGFGARELLKVGGR 762

  Fly   914 RPGAASPLLFEMATNQFQGC----QSGNEAVVVTRSFTARNSGVIPIRIEGFLIGSLPCEDFGFK 974
            .|||...|.|::..:....|    :...:.:.:|::|...|.|.:||.:....|....|:.:||:
Human   763 LPGAGGSLRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIGPLPITVSSLKINGYNCQGYGFE 827

  Fly   975 VMDCAGFDLGENEARKVEIAFSADFTTSAVKRSLTLLTNLTYDISYKLLAQMPAESVELCASLLV 1039
            |:||..|.|..|.:|.:.|.|:.|||:|.|.|.|:|:|....:..:.|...:|...:.|||.::.
Human   828 VLDCHQFSLDPNTSRDISIVFTPDFTSSWVIRDLSLVTAADLEFRFTLNVTLPHHLLPLCADVVP 892

  Fly  1040 RPGWESSL-KNAALVVLLASFGLVLVAAVFDAKAIMVQ-------QNAYDAA-RNKGPLQP---- 1091
            .|.||.|. :.....|.|:..|::|: |...|:.|:::       |||..:: :|.||:..
Human   893 GPSWEESFWRLTVFFVSLSLLGVILI-AFQQAQYILMEFMKTRQRQNASSSSQQNNGPMDVISPH 956

  Fly  1092 --TFNLRNIVKLQAEEAAAKAESV----QQQQKVKNGQLKELRKRTVVNSTNSKSKSKSSWSPWS 1150
              ..|.:|.:.........:.::.    ..|.:::|.     .||:.....:|:.|.|.|
Human   957 SYKSNCKNFLDTYGPSDKGRGKNCLPVNTPQSRIQNA-----AKRSPATYGHSQKKHKCS----- 1011

  Fly  1151 MDMNALSKHLQKAKPKTVVSTPVT-------PPAASAPAAAPVPLPEAKPVKKSSTPSPQGVPIS 1208
               ...|||  |.......||..|       |..:|.|||......:|......|.....|:.::
Human  1012 ---VYYSKH--KTSTAAASSTSTTTEEKQTSPLGSSLPAAKEDICTDAMRENWISLRYASGINVN 1071

  Fly  1209 VQV----------RPQKKVKPTPAVVLGTTK--------------PKQ---EVSTPVADQHEKSL 1246
            :|.          :.:..:|.|  :|.....              ||:   :.|...|:..|:.|
Human  1072 LQKNLTLPKNLLNKEENTLKNT--IVFSNPSSECSMKEGIQTCMFPKETDIKTSENTAEFKEREL 1134

  Fly  1247 A--KSSPPQQEN----ISPKPNKPPEQRVLKEQNG---------------SAKKMGKTPGRERER 1290
            .  |:|....||    .||:.::|....:.::.||               :.||:...|..|::.
Human  1135 CPLKTSKKLPENHLPRNSPQYHQPDLPEISRKNNGNNQQVPVKNEVDHCENLKKVDTKPSSEKKI 1199

  Fly  1291 ERRSKDQKLTNGTGAG-VGFRKPERKQR---------QKLNFGQTTNS-----------TSPPES 1334
            .:.|::...:...... |....|.||::         |.||:.::...           :.|||.
Human  1200 HKTSREDMFSEKQDIPFVEQEDPYRKKKLQEKREGNLQNLNWSKSRTCRKNKKRGVAPVSRPPEQ 1264

  Fly  1335 PDALKCISNPWETS 1348
            .| ||.:.:.:|.|
Human  1265 SD-LKLVCSDFERS 1277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmem131	NP_611073.2	TMEM131_like_N	54..137	CDD:463553	24/82 (29%)
		TMEM131_like	<880..>1064	CDD:437364	54/188 (29%)
TMEM131L	XP_047305855.1	TMEM131_like_N	120..203	CDD:463553	24/82 (29%)
		TMEM131_like	214..1658	CDD:437364	259/1350 (19%)