Protein Alignment Tmem131 and Tmem131l

DIOPT Version :10

• Sequence 1: NP_611073.2
• Gene: Tmem131 / 36761
• FlyBaseID: FBgn0034060
• Length: 1567
• Species: Drosophila melanogaster
• Sequence 2: NP_766269.3
• Gene: Tmem131l / 229473
• MGIID: 2443399
• Length: 1597
• Species: Mus musculus
• Alignment Length: 1801
• Identity: 340/1801 - (18%)
• Similarity: 588/1801 - (32%)
• Gaps: 602/1801 - (33%)

  Fly    54 LRLVPSRLDFGTWSVGQARSQTVTLFNQHSNRTLQLNAVAGPSPAFYSSFLGTREVPPQGNTTFN 118
            |...||.||||...:|...::.:..:|......:.:|:|...:..|:...:..|.:|..|..:|.
Mouse    91 LHFQPSVLDFGIQFLGHPAAKLLYAYNPSRESEVVVNSVFTAARHFHVPPVHCRVIPAMGKASFR 155

  Fly   119 VVFLPRQLGAIAADLLIHT-SFGQAELAVQGEGSECPYRLKPLVGIKAPMNATLTPEIHMYNPHE 182
            |:|||.:.|:|.:.|.|:| |.|.....|.|.|:.         .:....:|...|..:...|..
Mouse   156 VIFLPTEEGSIESSLFINTSSHGVFSYHVSGVGTR---------RVSTEGSAEQLPNAYFLLPQV 211

  Fly   183 RPLQILEIYSSGGEFQLELPSGGSEGPQNLWKIPPHTLKPVIRISFHGRTAGNHSAYIRIKVAEQ 247
            :.:|:.:..:......|                    |:..:..|.|.:..             |
Mouse   212 QSIQLSQTQAETTNTSL--------------------LRVQLECSLHNKVC-------------Q 243

  Fly   248 ELDIFIPVEFEILPRHSVYARNPLADFGRVATLNAPDALQFKLDV---RNDESRQLFGSYLRQIP 309
            :|                          :..:|.:.|||..::::   ..:.|:|
Mouse   244 QL--------------------------KSCSLGSDDALHLEMNIIVAVENSSKQ---------- 272

  Fly   310 GLSFDANNTSIVLDASLFEGDEIINDLLVINSNQSSTSPGADQPFTVLVRAEIFHGGLTFDRNAT 374
                ...||..:||..         .::.:.:::|.||
Mouse   273 ----PEENTQALLDHL---------SIVYVATDESDTS--------------------------- 297

  Fly   375 RFVTTSPEGVEGEPLERKRSLVVRNKFAIPLMLFNVSLTEPIDESILEVTLVGDPRILIQPDESV 439
                                                      |||.:.:.::.....||...:..
Mouse   298 ------------------------------------------DESAVNMYVLHSGNSLIWIQDIH 320

  Fly   440 ELLRLNLLNDQVPFKSFLRIETNVTVF-KLPLVSCSGRLHVSTQPIVLNFRQESLEKAAYNLELD 503
            ...:.|:|:.|  |:..| :.|:.|.| |:...:|  :...|....::..|:   :||:..::..
Mouse   321 HFSQKNVLSLQ--FEPVL-LSTSTTNFTKIASFTC--KAGTSCDSGIMGLRK---KKASPAMQAC 377

  Fly   504 LGTVPFAEMSRDGFVILRNDNPVPVRITNWFFKHPKTVYSQSTFLGCRATAIGHPVSVENDTKGW 568
            |.:                    ||              .|..|....:||..|..|.|..|..|
Mouse   378 LSS--------------------PV--------------VQGYFRTDASTAQFHIESHETATGVW 408

  Fly   569 HLCTEIRAGESAVFKVAIQTYEADATFGTLKVWTPYEVIRVRVKFEASVGHLEIDQEQLSFKNCF 633
            .:.......:|.|.|   ..:.:..|...|||                          |||:...
Mouse   409 SIWYRSHFDQSIVLK---DVFVSKETKHILKV--------------------------LSFRGPL 444

  Fly   634 ---PGKMCTAVLSIRSSFTHPVHVKGI----------------SFALPVGLRFKDFNA--KGTTI 677
               ||  |..:.|::      :.||||                .||:|:.:    |:|  |..::
Mouse   445 FLPPG--CWNIFSLK------LAVKGIVLNLFTNVFLTTNTGAIFAIPLQI----FSAPTKEGSL 497

  Fly   678 APQTLTKVGRIYFDPASVCRNNCYIRESTNDLAIFPSVPGGGNGNSGVINNNLLYDGVELRQRTE 742
            ..:.|...|..||...|...|..:.|..:.|.:.:       :.:|.:.|.  ||:..:..:..:
Mouse   498 GFEVLAHCGMHYFMGKSKTENPNWERSLSLDRSTW-------DMDSELANK--LYERWKKYKSGD 553

  Fly   743 LFRQLRRQLSSMSLTLHSEELPPLELDFSITIEWPKLVQFQP-IPPTP-------AIEVGQVQRQ 799
            ..|:....:|..:.|..|:|..|             .|.|.| :.|.|       |..:.....:
Mouse   554 ACRRNVLGMSQFAFTKKSKETEP-------------FVSFLPRVVPEPNLVLNFSATALRNSAVK 605

  Fly   800 WITLTNPSQSPLLLDYFLSDPAFAR-RTQLSLPH-------EVIDVSSTSCYLTDKEVFSLPEAG 856
            :..:.||:..|:.|. .|....:.| ...:.|.|       :::::|:....||.    :.|..|
Mouse   606 YFVVRNPTPQPVSLQ-LLPLSLYPRPEAAVRLLHKWFGTDMQMVNLSTGEFQLTQ----ACPYQG 665

  Fly   857 DP----------ILLPGGASLTIPITFSAQLPEKYCTLLHVRSNLTLYEAVWLQARAVQSQFRFG 911
            :|          :.|....:..:.:.|:.....|..:|:.:|:|||:.:.|.::....|...:.|
Mouse   666 EPSEESSLGALHVHLQALETRRVGVVFTPADYGKVTSLILIRNNLTVVDMVGVEGFGAQELLKVG 730

  Fly   912 NRRPGAASPLLFEMATNQFQGC----QSGNEAVVVTRSFTARNSGVIPIRIEGFLIGSLPCEDFG 972
            .|.|||...|.|::..:....|    :...:.:.:|::|...|.|.:||.:....|....|:.:|
Mouse   731 GRLPGAGGSLRFKVPESTLMDCHRQLKDSKQILSITKNFKVENIGPLPITVTSLKINGYNCQGYG 795

  Fly   973 FKVMDCAGFDLGENEARKVEIAFSADFTTSAVKRSLTLLTNLTYDISYKLLAQMPAESVELCASL 1037
            |:|:||..|.|..|.:|.:.|.|:.|||:|.|.|.|||:|....:..:.|...:|...:.|||.:
Mouse   796 FEVLDCHPFSLSPNTSRDISIVFTPDFTSSWVIRELTLVTAADLEFHFTLNVTLPHHMLPLCAEV 860

  Fly  1038 LVRPGWESSL-KNAALVVLLASFGLVLVAAVFDAKAIMVQ-------QNAYDAARNKG------- 1087
            :..|.||.|. :.....|.|:..|::|: |...|:.|:::       ||...:::..|
Mouse   861 VPGPSWEESFWRLTVFFVSLSLLGVILI-AFQQAQYILMEFMKTRQRQNGSSSSQQNGDPVAMIS 924

  Fly  1088 ---------------------------PLQPTFN-LRNIVKL----------------------- 1101
                                       |:.|:.: |:|..|.
Mouse   925 SHPHKSTCKNFLDTYSPSDKGRGKSCLPVGPSLSRLQNAAKRSPATYGHSQKKHKCSFYYSKQKP 989

  Fly  1102 QAEEAAAKAESVQQQQKVK------------------------------NGQL-KELR------- 1128
            .|..|::...:.:::|.|.                              ||.| |.|.
Mouse   990 SASAASSANVTTEEKQTVTLASSLSVAKEDICTNVLSENWVSLRYASGINGSLQKNLTLPKNVLH 1054

  Fly  1129 ------KRTVVNSTNSKSKSKSS----WSPWSMDMNALSKHL----------QKAKPKTVVST-P 1172
                  |.|||.:|.|:...|..    ..|...| :.:|:::          ||...|...|| |
Mouse  1055 KEESSLKNTVVTNTPSECSMKEGVHTYMFPKETD-SKISENVAELKEQEPCPQKTSKKPPESTLP 1118

  Fly  1173 VTPP----------------AASAPAAA------PVPLPEAKP--VKKSSTPSP-------QGVP 1206
            .|||                ...||..:      ||...:|:|  |:|:...||       |..|
Mouse  1119 KTPPQYLQSDLPEVSRKHGNKQQAPVRSEVDSFEPVRAADAEPSSVRKTQGASPEDTCSEKQDTP 1183

  Fly  1207 ISVQVRPQKKVK-------PTPAVVLGTTKPKQEVSTPVADQHEKSLAKSSPPQQENISPKPNKP 1264
            .:.|..|.:|.|       .|.|:....|:|.:.             .|.....|.:.||:|::.
Mouse  1184 SAEQEDPSRKRKLQERREGSTQALNWNKTRPCRR-------------NKKRASAQASSSPRPSEQ 1235

  Fly  1265 PEQRVLKE-------QNGSAKK-------MGKTPGRERERERRSKDQKLTNGTGAGVGFRKPERK 1315
            .|||::..       |:|:.:|       .|.:|      |||.:|..          ::|.|:|
Mouse  1236 SEQRLVCSDVRSWCAQDGAGEKCKAGTEVSGSSP------ERREEDSY----------YQKSEKK 1284

  Fly  1316 QRQKLNFGQTTNSTSPPESPDALKCISNPWETSSR-------VSFRDVLR-----TPQMAPTDNG 1368
            ...|.....:::..|...|..|.:.....|.:||.       |..:..|.     :||..|::..
Mouse  1285 CADKFCSDSSSDCGSSSGSVRASRGSWGSWSSSSSDCDRRPVVDIQHFLPPGDGVSPQNFPSEAS 1349

  Fly  1369 FDWN---HATSSSDLG----------------PIG-DNRKNATPPMVTSLW--EPLSATASNSLF 1411
            ...:   |..||:|:.                |.| ...|...||  ..||  :|:..|:|
Mouse  1350 VPLSLPQHVCSSTDVSVLPEFTESPCPGLPATPAGAGEEKGLYPP--GGLWPSQPVCLTSS---- 1408

  Fly  1412 ANTEVDFITPDAIYEQREREKPQWEQRSDLVMRQQLLLQQPQKLE---------------FQLRQ 1461
            .|..|:...|....|........:...|.....|...:..|.:|.               |....
Mouse  1409 FNCPVENGAPGVSQEPTSIPDSSFIDWSASCEGQFPSVYCPLELNDYNAFPEENMNYTNGFPCSS 1473

  Fly  1462 QEKISLLANMDPSNWAT------NWSPLGYSTWPNATAGIGVMRPPPGLEQSARQTHNLAQEQ-V 1519
            :.:...:.:..||.|.|      .|........|:.......:.|..||..|.....:...|. .
Mouse  1474 KVQTDFIGHSTPSTWNTPASMPAAWGHASLVNSPSYLTSTRSLSPMSGLFGSIWAPQSEVYETCC 1538

  Fly  1520 SAGPASGTGAALHGESLPTQY----DPFTSPSSIWSDTWRQSSQRN 1561
            ...||:.....:..:.:..:|    :||.:..::  |.|..::.||
Mouse  1539 PISPATEHATHMENQVMCKEYYLGFNPFRAYMNL--DIWTSTANRN 1582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmem131	NP_611073.2	TMEM131_like_N	54..137	CDD:463553	24/82 (29%)
		TMEM131_like	<880..>1064	CDD:437364	57/188 (30%)
Tmem131l	NP_766269.3	TMEM131_like_N	91..174	CDD:463553	24/82 (29%)
		TMEM131_like	185..1597	CDD:437364	312/1707 (18%)
		Required for Wnt-signaling inhibition and LRP6 degradation. /evidence=ECO:0000250|UniProtKB:A2VDJ0	696..916		63/220 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	907..928		3/20 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1096..1240		36/156 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1252..1322		18/85 (21%)